We exploited a tactic to obtain a low-cost, highefficiency, pollution-free, and stable nonenzymatic polyoxometalatebased heterogeneous electrode material for electrochemical sensing of glucose. It is first followed by the countercation exchange of K 2 Na 8 [Cu 4 (H 2 O) 2 (PW 9 O 34 ) 2 ] (CuPOM) using cesium chloride to prepare an insoluble CuPOM (Cs-CuPOM), which exhibits a uniform and perfect claviform shape with smooth surface. Further, it was mixed with graphite powder to prepare Cs-CuPOM-modified carbon paste electrode (Cs-CuPOM/CPE) with the Cs-CuPOM content between 15% and 50% in weight. This obtained electrode material Cs-CuPOM shows a better electrochemical sensor activity than Cs-MnPOM, Cs-FePOM, and other reported POM-based electrode materials for glucose oxidation on account of their quicker electron transfer kinetics, which also exhibits conspicuous characteristics with a wide linear range of 5−1500 μM. It also possesses a high sensitivity of 16.3 A M −1 cm −2 and a low limit of detection (LOD) of 0.99 × 10 −6 M at the signal-to-noise ratio of 3. The conspicuous sensing feature, low cost, and liable synthetic method can make Cs-CuPOM a promising candidate for the exploitation of a preeminent glucose sensor.