Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression

Vegt, Bea J. van der; Boer, Sietse F. de; Buwalda, Bauke; Ruiter, A.J.H. de; Jong, Jelly G. de; Koolhaas, Jaap M.

doi:10.1016/s0031-9384(01)00565-0

Cited by 61 publications

(36 citation statements)

References 30 publications

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“…Several studies in rats and mice show a widespread central nervous differentiation between proactive and reactive coping styles, for example at the level of the peptidergic modulation of the central nucleus of the amygdala [Roozendaal et al, 1992], the vasopressinergic neurons in the bed nucleus of the stria terminalis and its innervation of the lateral septum [Compaan et al, 1992;Koolhaas et al, 1998], the suprachiasmatic nucleus [Bult et al, 1993], pre-and post-synaptic 5-HT 1A receptor sensitivity [Van Der Vegt et al, 2001;Caramaschi et al, 2007], hippocampal mossy fiber system [Sluyter et al, 1994], and striatal dopaminergic mechanisms [Benus et al, 1991]. With the exception of serotonin, the causal involvement of these neurobiological substrates in the individual differentiation in coping style is far from clear.…”

Section: Neurobiology Of Coping Stylesmentioning

confidence: 99%

Individual Variation in Coping with Stress: A Multidimensional Approach of Ultimate and Proximate Mechanisms

et al. 2007

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Ecological studies on feral populations of mice, fish and birds elucidate the functional significance of phenotypes that differ individually in their behavioral and neuroendocrine response to environmental challenge. Within a species, the capacity to cope with environmental challenges largely determines individual survival in the natural habitat. Recent studies indicate that individual variation within a species may buffer the species for strong fluctuations in the natural habitat. A conceptual framework will be presented that is based on the view that individual variation in aggressive behavior can be considered more generally as a variation in actively coping with environmental challenges. Highly aggressive individuals adopt a proactive coping style whereas low levels of aggression indicate a more passive or reactive style of coping. Coping styles have now been identified in a range of species and can be considered as trait characteristics that are stable over time and across situations. The dimension of coping style seems to be independent of an emotionality dimension. Hence, in the analysis of the proximate mechanisms of stress and adaptation, one has to consider the possibility that the mechanisms which determine the type of stress response might be independent from those underlying the magnitude of the response. The two coping styles differ in a number of important neurobiological and neuroendocrine systems. For example, proactive males differ significantly from reactive males in the homeostatic control of serotonergic activity resulting in completely opposite dose response relationships of various serotonergic drugs. The results so far show that proactive coping is characterized by a strong inhibitory control of the 5-HT neuron via its somatodendritic 5-HT_1A autoreceptor. It is hypothesized that the regulation of serotonin release is causally related to coping style rather than emotionality. Understanding the functional individual variation as it occurs in nature and the underlying neurobiology and neuroendocrinology is fundamental in understanding individual vulnerability to stress related disease.

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Section: Neurobiology Of Coping Stylesmentioning

confidence: 99%

Individual Variation in Coping with Stress: A Multidimensional Approach of Ultimate and Proximate Mechanisms

et al. 2007

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“…SAL mice show higher hippocampal postsynaptic 5-HT1A receptor expression levels and binding capacity [Korte et al, 1996;Veenema et al, 2005b], and this is accompanied by a higher 5-HT responsiveness [van der Vegt et al, 2001;van Riel et al, 2002]. Although no line difference was found between LAL and SAL mice for presynaptic 5-HT1A autoreceptor expression levels in the dorsal raphe [Veenema et al, 2005b], a higher 5-HT1A autoreceptor sensitivity was found in SAL mice [Caramaschi et al, 2007].…”

Section: The Avp Systemmentioning

confidence: 99%

Neurobiological Mechanisms of Aggression and Stress Coping: A Comparative Study in Mouse and Rat Selection Lines

Veenema¹,

Neumann²

2007

Brain Behav Evol

131

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Aggression causes major health and social problems and constitutes a central problem in several psychiatric disorders. There is a close relationship between the display of aggression and stress coping strategies. In order to gain more insight into biochemical pathways associated with aggression and stress coping, we assessed behavioral and neurobiological responses in two genetically selected rodent models, namely wild house mice selectively bred for a short (SAL) and long (LAL) attack latency and Wistar rats bred for high (HAB) or low (LAB) anxiety-related behavior. Compared to their line counterparts, the SAL mice and the LAB rats display a high level of intermale aggression associated with a proactive coping style. Both the SAL mice and the LAB rats show a reduced hypothalamic-pituitary-adrenal (HPA) axis response to non-social stressors. However, when exposed to social stressors (resident-intruder, sensory contact), SAL mice show an attenuated HPA response, whereas LAB rats show an elevated HPA response. In both rodent lines, the display of aggression is associated with high neuronal activation in the central amygdala, but reduced neuronal activation in the lateral septum. Furthermore, in the lateral septum, SAL mice have a reduced vasopressinergic fiber network, and LAB rats show a decreased vasopressin release during the display of aggression. Moreover, the two lines show several indications of an increased serotonergic neurotransmission. The relevance of these findings in relation to high aggression and stress coping is discussed. In conclusion, exploring neurobiological systems in animals sharing relevant behavioral characteristics might be a useful approach to identify general mechanisms of action, which in turn can improve our understanding of specific behavioral symptoms in human psychiatric disorders.

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“…Long attack latency (LAL; low-aggressive to nonaggressive) mice showed lower 5-HT 1A receptor expression and binding capacity in hippocampus, frontal cortex and lateral septum than short attack latency (SAL; highaggressive) mice . Furthermore, LAL mice showed a lower sensitivity of postsynaptic 5-HT 1A receptors (as shown by a lower 8-OH-DPAT-induced hypothermia; Van der Vegt et al 2001) and an attenuated 5-HT responsiveness in the hippocampus (measured by means of electrophysiology; Van Riel et al 2002) than SAL mice. Currently, it is not known, however, whether the observed difference in postsynaptic 5-HT 1A receptors is related to a difference in brain 5-HT metabolism between LAL and SAL mice.…”

Section: Introductionmentioning

confidence: 97%

Differences in the effects of 5-HT1A receptor agonists on forced swimming behavior and brain 5-HT metabolism between low and high aggressive mice

et al. 2004

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It is unlikely that the difference in 5-HT(1A) properties between LAL and SAL mice is an adaptive compensatory reaction to changes in 5-HT metabolism. Although unspecific motor effects, at least in SAL mice, cannot be ruled out, it is suggested that the behavioral effects of 8-OH-DPAT and S-15535 may be mediated by predominant activation of postsynaptic 5-HT(1A) receptors in LAL mice and by presynaptic 5-HT(1A) receptors in SAL mice.

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Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression

Cited by 61 publications

References 30 publications

Individual Variation in Coping with Stress: A Multidimensional Approach of Ultimate and Proximate Mechanisms

Individual Variation in Coping with Stress: A Multidimensional Approach of Ultimate and Proximate Mechanisms

Neurobiological Mechanisms of Aggression and Stress Coping: A Comparative Study in Mouse and Rat Selection Lines

Differences in the effects of 5-HT1A receptor agonists on forced swimming behavior and brain 5-HT metabolism between low and high aggressive mice

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