Enhanced skin penetration of Finasteride loaded DMSO-liposomes for the treatment of androgenic alopecia: comparison with conventional liposomes

Ramkar, Shweta; Kaurav, Monika; Sudheesh, M.S.; Pandey, Ravi Shankar

doi:10.1080/03639045.2023.2182122

Cited by 2 publications

(3 citation statements)

References 22 publications

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“…Similar findings were shown when comparing the ethosomal formulation (F6) with 400 mg PL (70.30 ± 1.81%) and formulation (F11) with 200 mg PL (44.43 ± 1.33%). The increase in the EE% with an increase in the PL concentration could be related to the lipophilicity of RS, since the lipophilic medication would find a high lipid surface area to be encapsulated in the lipoid phase of the vesicles [41].…”

Section: Effect Of Independent Factors On Ee% (R 3 )mentioning

confidence: 99%

Tailoring Risperidone-Loaded Glycethosomal In Situ Gels Using Box–Behnken Design for Treatment of Schizophrenia-Induced Rats via Intranasal Route

Abdallah,

El-Horany,

El-Nahas

et al. 2023

Pharmaceutics

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Schizophrenic patients often face challenges with adherence to oral regimens. The study aimed to highlight the potentiality of intranasal ethanol/glycerin-containing lipid-nanovesicles (glycethosomes) incorporated into in situ gels for sustaining anti-psychotic risperidone (RS) release. The Box–Behnken Design (BBD) was followed for in vitro characterization. Glycethosomal-based in situ gels were examined by physical, ex vivo, and in vivo investigations. The ethanol impact on minimizing the vesicle size (VS) and enhancing the zeta potential (ZP) and entrapment efficiency (EE%) of nanovesicles was observed. Glycerin displayed positive action on increasing VS and ZP of nanovesicles, but reduced their EE%. After incorporation into various mucoadhesive agent-enriched poloxamer 407 (P407) in situ gels, the optimized gel containing 20% P407 and 1% hydroxypropyl methyl cellulose-K4M (HPMC-K4M) at a 4:1 gel/glycethosomes ratio showed low viscosity and high spreadability with acceptable pH, gel strength, and mucoadhesive strength ranges. The ethanol/glycerin mixture demonstrated a desirable ex vivo skin permeability of RS through the nasal mucosa. By pharmacokinetic analysis, the optimized gel showed eight-fold and three-fold greater increases in RS bioavailability than the control gel and marketed tablet, respectively. Following biochemical assessments of schizophrenia-induced rats, the optimized gel boosted the neuroprotective, anti-oxidant, and anti-inflammatory action of RS in comparison to other tested preparations. Collectively, the intranasal RS-loaded glycethosomal gel offered a potential substitute to oral therapy for schizophrenic patients.

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Section: Effect Of Independent Factors On Ee% (R 3 )mentioning

confidence: 99%

Tailoring Risperidone-Loaded Glycethosomal In Situ Gels Using Box–Behnken Design for Treatment of Schizophrenia-Induced Rats via Intranasal Route

Abdallah,

El-Horany,

El-Nahas

et al. 2023

Pharmaceutics

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“…The expression of sulfotransferase in the scalp is different in different individuals, explaining the heterogeneity in clinical responses to MXD therapy [11]. In some studies, the skin permeability and retention of FIN and MXD were enhanced using liposome-based delivery systems [12][13][14]. For example, the use of FIN has been limited because its systemic administration can cause sexual dysfunction.…”

Section: Introductionmentioning

confidence: 99%

“…To solve this problem, DMSO-modified liposomes were prepared for the topical delivery of FIN. The permeation capacity of DMSO could promote FIN delivery to HFs, mitigating the adverse effects of systemic administration [13]. In addition to drug treatment, HF transplantation is another therapeutic option for hair loss.…”

Section: Introductionmentioning

confidence: 99%

Innovative Strategies for Hair Regrowth and Skin Visualization

Mai

Cheng

et al. 2023

Pharmaceutics

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Today, about 50% of men and 15–30% of women are estimated to face hair-related problems, which create a significant psychological burden. Conventional treatments, including drug therapy and transplantation, remain the main strategies for the clinical management of these problems. However, these treatments are hindered by challenges such as drug-induced adverse effects and poor drug penetration due to the skin’s barrier. Therefore, various efforts have been undertaken to enhance drug permeation based on the mechanisms of hair regrowth. Notably, understanding the delivery and diffusion of topically administered drugs is essential in hair loss research. This review focuses on the advancement of transdermal strategies for hair regrowth, particularly those involving external stimulation and regeneration (topical administration) as well as microneedles (transdermal delivery). Furthermore, it also describes the natural products that have become alternative agents to prevent hair loss. In addition, given that skin visualization is necessary for hair regrowth as it provides information on drug localization within the skin’s structure, this review also discusses skin visualization strategies. Finally, it details the relevant patents and clinical trials in these areas. Together, this review highlights the innovative strategies for skin visualization and hair regrowth, aiming to provide novel ideas to researchers studying hair regrowth in the future.

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Enhanced skin penetration of Finasteride loaded DMSO-liposomes for the treatment of androgenic alopecia: comparison with conventional liposomes

Cited by 2 publications

References 22 publications

Tailoring Risperidone-Loaded Glycethosomal In Situ Gels Using Box–Behnken Design for Treatment of Schizophrenia-Induced Rats via Intranasal Route

Tailoring Risperidone-Loaded Glycethosomal In Situ Gels Using Box–Behnken Design for Treatment of Schizophrenia-Induced Rats via Intranasal Route

Innovative Strategies for Hair Regrowth and Skin Visualization

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