Enhanced Sleep Is an Evolutionarily Adaptive Response to Starvation Stress in Drosophila

Slocumb, Melissa E.; Regalado, Josue M.; Yoshizawa, Masato; Neely, G. Gregory; Mašek, Pavel; Gibbs, Allen G.; Keene, Alex C.

doi:10.1371/journal.pone.0131275

Cited by 45 publications

(60 citation statements)

References 42 publications

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“…For example, Drosophila has been reported to show lower locomotor activity under prolonged nutritionally adverse conditions (Rion and Kawecki, 2007;Slocumb et al, 2015). Inner-nest workers did indeed show a reduction in foraging activity during the first 3 weeks of the experiment, supporting this hypothesis in our study.…”

Section: Discussionsupporting

confidence: 87%

Resistance to nutritional stress in ants: when being fat is advantageous

Dussutour

Poissonnier

Buhl

et al. 2016

Journal of Experimental Biology

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In ants, nutrient acquisition for the whole colony relies on a minority of workers, the foragers, which are often old and lean. Some studies have shown that the link between age, physiology and foraging activity is more flexible than once thought, especially in response to colony or environmental perturbations. This great plasticity offers the intriguing possibility to disentangle the effect of age, behaviour and physiology on the ants' abilities to cope with nutritional stresses. In this paper, we first looked at the capacity of groups of foragers and inner-nest workers to resist starvation and macronutrient imbalance. Second, we investigated whether behavioural task reversion modified the tolerance to nutritional stresses and by extension, changed mortality rate. We found that inner-nest workers live longer than foragers under nutritional stresses but not under optimal conditions. The reversion from foraging to inner-nest activities is followed by an increase in fat content and longevity. Finally, we demonstrated that changes in fat content associated with behavioural transition are highly flexible and strongly correlated to tolerance of nutritional stress. Our results have considerable implications for our understanding of the population dynamics of social insects under adverse nutritional conditions.

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Section: Discussionsupporting

confidence: 87%

Resistance to nutritional stress in ants: when being fat is advantageous

Dussutour

Poissonnier

Buhl

et al. 2016

Journal of Experimental Biology

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“…In the next stage of this investigation, we examined three long‐term selected populations of desiccation resistant flies (DR populations A, B, and C) obtained through artificial selection through about 200 generations (Slocumb et al, ) (also provided by Dr. Allen G. Gibbs). We observed a significant reduction in the number of ABLKs in two of the three populations.…”

Section: Resultsmentioning

confidence: 99%

Variability in the number of abdominal leucokinergic neurons in adult Drosophila melanogaster

Alvarez-Rivero

Moris-Sanz

Estacio-Gómez

et al. 2016

J of Comparative Neurology

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Developmental plasticity allows individuals with the same genotype to show different phenotypes in response to environmental changes. An example of this is how neuronal diversity is protected at the expense of neuronal number under sustained undernourishment during the development of the Drosophila optic lobe. In the development of the Drosophila central nervous system, neuroblasts go through two phases of neurogenesis separated by a period of mitotic quiescence. Although during embryonic development much evidence indicates that both cell number and the cell fates generated by each neuroblast are very precisely controlled in a cell autonomous manner, after quiescence extrinsic factors control the reactivation of neuroblast proliferation in a not as known way. Moreover, there is very little information about whether environmental changes affect lineage progression during postembryonic neurogenesis. Using as a model system the pattern of abdominal leucokinergic neurons (ABLKs), we have analysed how changes in a set of environmental factors affect the number of ABLKs generated during postembryonic neurogenesis. We describe the variability in ABLK number between individuals and between hemiganglia of the same individual and, by genetic analysis, we identify the Bithorax-Complex genes and the Ecdysone hormone as critical factors in these differences. We have also explored the possible adaptive roles involved in this process.

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“…For 519 instance, Schwasinger- Schmidt et al (2012) found that activity of flies with high starvation 520 resistance was reduced following 15 generations of selection for starvation resistance in both 521 males and females. Slocumb et al (2015) also found that waking activity was reduced in lines 522 selected to have high starvation resistance. Although previous associations between increased 523 starvation tolerance and lower activity levels, metabolic rate, and changes in behavior have been 524 observed (Murphey and Hall 1969;Hoffmann and Parsons 1989a;Blows and Hoffman 1993; and starvation resistance may be genetically correlated Rose et al 1992;536 Chippindale et al 1996;Harshman et al 1999;Schwasinger-Schmidt et al 2012;Slocumb et al 537 2015).…”

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confidence: 92%

“…A more intensive sampling of the DSPR would be necessary to thoroughly 483 investigate the genetic correlation between starvation and desiccation resistance. One physiological mechanism that may increase tolerance to environmental stressors is 493 a reduction in metabolic rate (Lighton and Bartholomew 1988;Hoffmann and Parsons 1989a;b, 494 1991;Chippindale et al 1996;Djawdan et al 1997;Marron et al 2003;Rion and Kawecki 2007;495 Schwasinger -Schmidt et al 2012;Slocumb et al 2015). Indeed, selection for both starvation and 496 desiccation resistance has been shown to lead to a correlated change in activity level, an indirect 497 proxy for metabolic rate Parsons 1989b, 1993;Schwasinger-Schmidt et al 2012).…”

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confidence: 99%

Dissection of complex, fitness-related traits in multiple Drosophila mapping populations offers insight into the genetic control of stress resistance

Everman

McNeil

Hackett

et al. 2018

Preprint

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44We leverage two complementary Drosophila melanogaster mapping panels to genetically dissect 45 starvation resistance, an important fitness trait. Using >1600 genotypes from the multiparental 46Drosophila Synthetic Population Resource (DSPR) we map numerous starvation stress QTL that 47 the DGRP. We found strong phenotypic correlations among studies, but extremely low overlap 59 in the sets of genomewide significant sites. Despite this, our analyses revealed that the most 60 highly-associated variants from each study typically showed the same additive effect sign in 61 independent studies, in contrast to otherwise equivalent sets of random variants. This 62 consistency provides evidence for reproducible trait-associated sites in a widely-used mapping 63 panel, and highlights the polygenic nature of starvation resistance. 64 65 Periods of food scarcity and suboptimal nutrient resources present an important 66 challenge for nearly all species (McCue 2010), and this form of environmental stress can limit the 67 survival of individuals with poor nutritional status and reduced stress resistance (Harshman et al. 68 1999;Lee and Jang 2014). As a result, starvation stress resistance has direct implications for the 69 fitness of individuals as they experience resource variability in natural populations. Starvation 70 resistance is a classic quantitative, fitness-related trait that is associated with several other 71 phenotypes that influence survival, lifespan, and reproduction (Service and Rose 1985; Da Lage 72 et al

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Enhanced Sleep Is an Evolutionarily Adaptive Response to Starvation Stress in Drosophila

Cited by 45 publications

References 42 publications

Resistance to nutritional stress in ants: when being fat is advantageous

Resistance to nutritional stress in ants: when being fat is advantageous

Variability in the number of abdominal leucokinergic neurons in adult Drosophila melanogaster

Dissection of complex, fitness-related traits in multiple Drosophila mapping populations offers insight into the genetic control of stress resistance

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