Enhanced spatial ability in aged dogs following dietary and behavioural enrichment

Nippak, Pria; Mendelson, J. R.; Muggenburg, Bruce A.; Milgram, Norton W.

doi:10.1016/j.nlm.2007.01.001

Cited by 24 publications

(17 citation statements)

References 82 publications

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“…Findings from several studies have demonstrated that performance of dogs in cognitive tests (including those that examine spatial memory) can be improved by various substances (including antioxidants, mitochondrial cofactors and a pharmaceutical with alpha-1 adrenergic agonist action) and by behavioural enrichment [21][22][23][24][25]. Oral administration of resveratrol has been used with success in previous studies of cognitive function in animals [3,5,9,10].…”

Section: Discussionmentioning

confidence: 99%

Effect of Resveratrol Supplementation on the Performance of Dogs in an Eight-Arm Radial Maze

Story¹

2012

TONUTRJ

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Abstract:Resveratrol supplements are marketed on the premise they enhance cognitive function. We explored effects of resveratrol supplementation on cognitive function, in the absence of pathology, by assessing effects of resveratrol on the performance of young, healthy, recently gonadectomised dogs in an eight-arm radial maze. Effects of gonadectomy on cognition were also assessed. Performances of untreated intact dogs, resveratrol-treated gonadectomised dogs (60mg/day of resveratrol orally) and placebo-treated gonadectomised dogs were compared in three phases. Dogs received the placebo or resveratrol for two to four weeks before testing began. In phase one, untreated intact (n = 16), resveratrol-treated gonadectomised (n = 6) and placebo-treated gonadectomised dogs (n = 5) were allowed to choose all maze arms they entered. In phase two, untreated intact (n = 15), resveratrol-treated gonadectomised (n = 6) and placebo-treated gonadectomised dogs (n = 5) entered four predetermined arms and then made four free choices from all eight arms. In phase three, a subset of dogs previously tested as untreated intact dogs in phases one and two were tested. In phase three, placebotreated gonadectomised (n = 6) and resveratrol-treated gonadectomised dogs (n = 6) entered seven predetermined arms and then had free choice between a previously opened arm and the unopened arm. Performance in the maze did not differ significantly between gonadectomised dogs receiving the placebo and gonadectomised dogs receiving resveratrol or between untreated intact dogs and gonadectomised dogs receiving the placebo. We conclude that resveratrol treatment does not improve (and gonadectomy does not impair) the aspects of cognitive function that were tested by the radial arm maze trials in young, healthy dogs receiving extensive handling and environmental/behavioural enrichment.

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Section: Discussionmentioning

confidence: 99%

Effect of Resveratrol Supplementation on the Performance of Dogs in an Eight-Arm Radial Maze

Story¹

2012

TONUTRJ

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“…Additional improvements in cognition in response to the antioxidant-enriched diet were observed on repeated measures of visual discrimination and reversal learning [137]. Spatial memory was also improved in aged dogs provided with the antioxidant enriched diet after long term treatment (>2.0 years) [140]. Interestingly, young dogs fed the antioxidant diet showed no cognitive improvements on the oddity task as well as other learning problems [137, 141] suggesting the antioxidant diet selectively corrected an oxidative defect present in the aged brain.…”

Section: A Longitudinal Study Of Antioxidants In Aged Dogsmentioning

confidence: 99%

Oxidative Damage and Cognitive Dysfunction: Antioxidant Treatments to Promote Healthy Brain Aging

Head

2008

Neurochem Res

112

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Oxidative damage in the brain may lead to cognitive impairments in aged humans. Further, in age-associated neurodegenerative disease, oxidative damage may be exacerbated and associated with additional neuropathology. Epidemiological studies in humans show both positive and negative effects of the use of antioxidant supplements on healthy cognitive aging and on the risk of developing Alzheimer disease (AD). This contrasts with consistent behavioral improvements in aged rodent models. In a higher mammalian model system that naturally accumulates human-type pathology and cognitive decline (aged dogs), an antioxidant enriched diet leads to rapid learning improvements, memory improvements after prolonged treatment and cognitive maintenance. Cognitive benefits can be further enhanced by the addition of behavioral enrichment. In the brains of aged treated dogs, oxidative damage is reduced and there is some evidence of reduced AD-like neuropathology. In combination, antioxidants may be beneficial for promoting healthy brain aging and reducing the risk of neurodegenerative disease.

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“…Lifestyle behaviors such as diet, physical activity, and social engagement not only cluster together but also exert additive effects on cognitive function such that their combined impact is greater than any behavior separately (25,26). Animal studies have found that cognitively stimulating environments, a factor linked to SEP in humans, can augment or mask the behavioral impacts of dietary interventions (27,28). In prospective studies the deleterious association of high sodium intake with accelerated cognitive decline (29) and the protective influence of a Mediterranean diet on incidence of Alzheimer disease, at least qualitatively, appear to be dependent on an individualÕs level of physical activity (30).…”

Section: Introductionmentioning

confidence: 99%

Relationship between Diet Quality and Cognition Depends on Socioeconomic Position in Healthy Older Adults

Parrott

Shatenstein

Ferland

et al. 2013

The Journal of Nutrition

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Both diet quality and socioeconomic position (SEP) have been linked to age-related cognitive changes, but there is little understanding of how the socioeconomic context of dietary intake may shape its cognitive impact. We examined whether equal adherence to "prudent" and "Western" dietary patterns, identified by principal components analysis, was associated with global cognitive function [Modified Mini-Mental State Examination (3MS)] in independently living older adults with different SEPs (aged 68-84 y; n = 1099). The interaction of dietary pattern adherence with household income, educational attainment, occupational prestige, and a composite indicator of SEP combining all 3 was examined in multiple-adjusted mixed models over 3 y of follow-up in participants of the NuAge study (Quebec Longitudinal Study on Nutrition and Successful Aging). Adherence to the prudent pattern (vegetables, fruits, fish, poultry, and lower-fat dairy products) was related to higher 3MS scores at recruitment only in the upper categories of income [parameter estimate (B): 0.56; 95% CI: 0.11, 1.01], education (B: 0.44; 95% CI: 0.080, 0.80), or composite SEP (B: 0.37; 95% CI: 0.045, 0.70). High prudent pattern adherence was associated with less cognitive decline only in those with low composite SEP (B: 0.25; 95% CI: 0.0094, 0.50). Conversely, adherence to the Western pattern (meats, potatoes, processed foods, and higher-fat dairy products) was associated with more cognitive decline (B: -0.23; 95% CI: -0.43, -0.032) only in those with low educational attainment. In summary, among individuals with equivalent diet quality, the magnitude and characteristics of the diet-cognition relationship depended on their socioeconomic circumstances. These results suggest that interventions promoting retention of cognitive function through improved diet quality would provide maximum benefit to those with relatively low SEP.

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Enhanced spatial ability in aged dogs following dietary and behavioural enrichment

Cited by 24 publications

References 82 publications

Effect of Resveratrol Supplementation on the Performance of Dogs in an Eight-Arm Radial Maze

Effect of Resveratrol Supplementation on the Performance of Dogs in an Eight-Arm Radial Maze

Oxidative Damage and Cognitive Dysfunction: Antioxidant Treatments to Promote Healthy Brain Aging

Relationship between Diet Quality and Cognition Depends on Socioeconomic Position in Healthy Older Adults

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