Enhanced specific absorption rate in silanol functionalized Fe 3 O 4 core–shell nanoparticles: Study of Fe leaching in Fe 3 O 4 and hyperthermia in L929 and HeLa cells

Majeed, Jerina; Pradhan, Lina; Ningthoujam, R. S.; Vatsa, R.K.; Bahadur, D.; Tyagi, A. K.

doi:10.1016/j.colsurfb.2014.07.019

Cited by 79 publications

(37 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Besides their specific magnetic properties [54], magnetite (Fe 3 O 4 ) nanoparticles are friendly to biological tissues and fluids, the biocompatibility [34,35,36,55] making them promising candidates for numerous biomedical applications, like: (1) drug delivery systems [56,57,58,59]; (2) hyperthermia cancer treatment [60,61,62,63,64]; (3) contrasting agent in magnetic resonance imaging [11,27,65,66]; (4) inhibition of biofilm development [67,68,69,70,71,72,73]. …”

Section: Discussionmentioning

confidence: 99%

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

et al. 2017

View full text Add to dashboard Cite

Nanotechnology has been successfully used for the fabrication of targeted anti-cancer drug carriers. This study aimed to obtain Fe3O4 nanoparticles functionalized with Gemcitabine to improve the cytotoxic effects of the chemotherapeutic substance on cancer cells. The (un) functionalized magnetite nanoparticles were synthesized using a modified co-precipitation method. The nanoconjugate characterization was performed by XRD, SEM, SAED and HRTEM; the functionalizing of magnetite with anti-tumor substances has been highlighted through TGA. The interaction with biologic media has been studied by means of stability and agglomeration tendency (using DLS and Zeta Potential); also, the release kinetics of the drug in culture media was evaluated. Cytotoxicity of free-Gemcitabine and the obtained nanoconjugate were evaluated on human BT 474 breast ductal carcinoma, HepG2 hepatocellular carcinoma and MG 63 osteosarcoma cells by MTS. In parallel, cellular morphology of these cells were examined through fluorescence microscopy and SEM. The localization of the nanoparticles related to the cells was studied using SEM, EDX and TEM. Hemolysis assay showed no damage of erythrocytes. Additionally, an in vivo biodistribution study was made for tracking where Fe3O4@Gemcitabine traveled in the body of mice. Our results showed that the transport of the drug improves the cytotoxic effects in comparison with the one produced by free Gemcitabine for the BT474 and HepG2 cells. The in vivo biodistribution test proved nanoparticle accumulation in the vital organs, with the exception of spleen, where black-brown deposits have been found. These results indicate that our Gemcitabine-functionalized nanoparticles are a promising targeted system for applications in cancer therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

et al. 2017

View full text Add to dashboard Cite

show abstract

“…For example in "in vitro" experiments, 14 nm magnetic nanoclusters killed about 74% of MCF-7 cancer cells, by applying temperature of 45°C for 1 hour [6]. Similarly, a temperature of 43°C for about 17 minutes reduced the viability of HeLa cells exposed to an alternating magnetic field in the presence of silica coated iron oxide nanoparticles (NPs) [7]. SPIONs can be internalized in human mesenchymal stem cells without affecting viability and structure.…”

Section: Introductionmentioning

confidence: 99%

Innovative superparamagnetic iron-oxide nanoparticles coated with silica and conjugated with linoleic acid: Effect on tumor cell growth and viability

Muzio

Miola

Ferraris

et al. 2017

Materials Science and Engineering: C

View full text Add to dashboard Cite

“…In general, a thermal treatment to attack cancer cells at mild temperatures in the range 40–45 °C would lead to apoptotic cancer cell death by inducing cancer‐cell shrinkage and increasing the space between the cells, which would enable anticancer drugs to spread throughout the tumor and destroy the cancer cells in the tumor. This is the so‐called MFH . The other benefit of this strategy is the utilization of heat generated by the MNPs as a trigger for the gradual release of anticancer drugs from the MNPs, which prevents the anticancer drugs from leaving the tumor and thus reduces side effects.…”

Section: Introductionmentioning

confidence: 99%

Superparamagnetic Gadolinium Ferrite Nanoparticles with Controllable Curie Temperature – Cancer Theranostics for MR‐Imaging‐Guided Magneto‐Chemotherapy

et al. 2016

View full text Add to dashboard Cite

A facile polyol approach for preparing low‐Curie‐temperature (TC) gadolinium‐doped iron oxide nanoparticles (GdIO NPs) for targeted magnetic hyperthermia and chemotherapy coupled with T1–T2 dual‐model magnetic resonance (MR) imaging (where T1 and T2 are the longitudinal and transverse relaxation times, respectively) is reported. A small amount of Gd doping decreases the TC of iron oxide down to about 400 K. In the presence of ethanolamine, controlled polyol synthesis leads to the formation of low‐TC, highly magnetic (52.87 emu g–1), and size‐controlled (ca. 10 nm) GdIO NPs. A further conjugation with folate and a chemotherapeutic drug has been developed, and the whole system is used for in vitro magneto‐chemotherapy (magnetic hyperthermia and chemotherapy) for cancer treatment. The synthesized GdIO NPs are stable colloids that are hemocompatible and cytocompatible over a wide concentration range and have a high affinity towards cancer cells. The release of a chemotherapeutic drug from the GdIO NPs significantly affects cancer cell viability, and the T1–T2 dual‐model magnetic resonance enhances bioimaging in a breast cancer cell model. We suggest that the chemotherapeutic‐drug‐conjugated GdIO NPs have great potential for cell targeting and magnetic resonance imaging in cancer magneto‐chemotherapy.

show abstract

Enhanced specific absorption rate in silanol functionalized Fe 3 O 4 core–shell nanoparticles: Study of Fe leaching in Fe 3 O 4 and hyperthermia in L929 and HeLa cells

Cited by 79 publications

References 33 publications

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

Innovative superparamagnetic iron-oxide nanoparticles coated with silica and conjugated with linoleic acid: Effect on tumor cell growth and viability

Superparamagnetic Gadolinium Ferrite Nanoparticles with Controllable Curie Temperature – Cancer Theranostics for MR‐Imaging‐Guided Magneto‐Chemotherapy

Contact Info

Product

Resources

About