Enhanced specific loss power from Resovist® achieved by aligning magnetic easy axes of nanoparticles for hyperthermia

Shi, Guannan; Takeda, Ryoji; Trisnanto, Suko Bagus; Yamada, Tsutomu; Ota, Satoshi; Takemura, Yasushi

doi:10.1016/j.jmmm.2018.10.070

Cited by 48 publications

(28 citation statements)

References 39 publications

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“…The SLP of the NiFe-Cu nanocube under the applied field of H AC = 4 kA/m at 100 kHz is calculated to be 1.6 W/g from the magnetization curve along the <100> direction, shown in Figure 7 a, which does not depend on the crystallographic direction of the applied field. This value of SLP is comparable with that of Resovist ® (SLP = 3.2 W/g), calculated for the same AC field condition [ 4 ]. Resovist ® is a contrast agent that is clinically used in magnetic resonance imaging, which also exhibits a high SLP value for hyperthermia.…”

Section: Discussionsupporting

confidence: 85%

“…The magnetic hyperthermia treatment using magnetic nanoparticles [ 1 , 2 ] relies on the generation of heat from magnetic nanoparticles under the applied AC magnetic field. Much attention has been paid to improving the specific loss power (SLP), which is also referred to as the specific absorption rate of magnetic nanoparticles, and to clarifying the relationship between the SLP and the shape magnetic anisotropy of magnetic nanoparticles [ 3 , 4 , 5 , 6 ]. Magnetocrystalline anisotropy is another case of magnetic anisotropy that originates from the internal energy, depending on the direction in the crystal lattice of a magnetic material.…”

Section: Introductionmentioning

confidence: 99%

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Magnetization Characteristics of Oriented Single-Crystalline NiFe-Cu Nanocubes Precipitated in a Cu-Rich Matrix

et al. 2020

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In this study, we evaluated the magnetization properties of a magnetic alloy with single-crystalline cubic nanostructures, in order to clarify its magnetocrystalline anisotropy. Upon applying a specific annealing treatment to the CuNiFe base material, the precipitated magnetic particles grew into cubic granules, resulting in the formation of nanometric cubic single crystals of magnetic CuNiFe in a nonmagnetic Cu-rich matrix. The cubic nanostructures of CuNiFe were oriented along their crystallographic axis, in the <100> direction of the face-centered-cubic structure. We evaluated the static magnetization properties of the sample, which originated primarily from the CuNiFe nanocubes precipitated in the Cu-rich matrix, under an applied DC magnetic field. The magnetocrystalline anisotropy was readily observed in the magnetization curves. The <111> axis of the CuNiFe was observed to be the easy axis of magnetization. We also investigated the dynamic magnetization properties of the sample under an AC magnetic field. By subtracting the magnetic signal induced by the eddy current from the magnetization curves of the sample, we could obtain the intrinsic AC magnetization properties of the CuNiFe nanocubes.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Magnetization Characteristics of Oriented Single-Crystalline NiFe-Cu Nanocubes Precipitated in a Cu-Rich Matrix

et al. 2020

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“…29,30 We note, however, that easy axis orientation via particle rotation can affect the Néel reversal mechanism. 15,[31][32][33][34] In the following we will analyse the attainable efficiency in electromagnetic-toheat energy conversion in terms of Néel reversal.…”

Section: Theoretical Frameworkmentioning

confidence: 99%

How size, shape and assembly of magnetic nanoparticles give rise to different hyperthermia scenarios

et al. 2021

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“…[ 58 ] The heating behavior of nanoparticles can be largely influenced by mesoscale ensemble effects such as arrangement, [ 59 ] interactions, [ 60 ] and alignment. [ 61,62 ] Additionally, deviation from the perfect single‐crystalline structure can affect particles magnetization and thus their magnetic heating. In case of small particles (i.e., smaller than ≈14 nm), a defect‐induced magnetic hardening can be useful to improve their heating performance.…”

Section: Iron Oxide Nanoparticles In Biomedicinementioning

confidence: 99%

Embracing Defects and Disorder in Magnetic Nanoparticles

2021

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Iron oxide nanoparticles have tremendous scientific and technological potential in a broad range of technologies, from energy applications to biomedicine. To improve their performance, single‐crystalline and defect‐free nanoparticles have thus far been aspired. However, in several recent studies, defect‐rich nanoparticles outperform their defect‐free counterparts in magnetic hyperthermia and magnetic particle imaging (MPI). Here, an overview on the state‐of‐the‐art of design and characterization of defects and resulting spin disorder in magnetic nanoparticles is presented with a focus on iron oxide nanoparticles. The beneficial impact of defects and disorder on intracellular magnetic hyperthermia performance of magnetic nanoparticles for drug delivery and cancer therapy is emphasized. Defect‐engineering in iron oxide nanoparticles emerges to become an alternative approach to tailor their magnetic properties for biomedicine, as it is already common practice in established systems such as semiconductors and emerging fields including perovskite solar cells. Finally, perspectives and thoughts are given on how to deliberately induce defects in iron oxide nanoparticles and their potential implications for magnetic tracers to monitor cell therapy and immunotherapy by MPI.

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Enhanced specific loss power from Resovist® achieved by aligning magnetic easy axes of nanoparticles for hyperthermia

Cited by 48 publications

References 39 publications

Magnetization Characteristics of Oriented Single-Crystalline NiFe-Cu Nanocubes Precipitated in a Cu-Rich Matrix

Magnetization Characteristics of Oriented Single-Crystalline NiFe-Cu Nanocubes Precipitated in a Cu-Rich Matrix

How size, shape and assembly of magnetic nanoparticles give rise to different hyperthermia scenarios

Embracing Defects and Disorder in Magnetic Nanoparticles

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