Enhanced sterilization and healing of cutaneous pseudomonas infection using 5-aminolevulinic acid as a photosensitizer with 410-nm LED light

Katayama, Bunpei; Ozawa, Toshiyuki; Morimoto, Kazushige; Awazu, Kunio; Ito, Nobuhisa; Honda, N.; Oiso, Naoki; Tsuruta, Daisuke

doi:10.1016/j.jdermsci.2018.03.001

Cited by 29 publications

(45 citation statements)

References 43 publications

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“…Eleven studies examined the effect of PDT on infected wounds at various times after treatment . As expected, several studies showed that bacterial infections delayed wound healing: as a result, the untreated infected wounds had significantly greater wound sizes at various assessment time points than the uninfected wounds .…”

Section: Resultsmentioning

confidence: 90%

“…The animal species used in the 19 studies were mice (n = 16) and rats (n = 3) . Of the 16 mouse studies, nine used BALB/c mice, 4 utilised Swiss albino mice, two used C57BL/ksj db/db mice, and one used CD1 mice . One study did not report the mouse strain that was used.…”

Section: Resultsmentioning

confidence: 99%

“…The second‐generation photosensitiser that is most commonly used in recent times is 5‐aminolevulinic acid. It was used in two studies . Other used photosensitisers were 5‐phenyl‐10; 15, 20‐tris (N‐methyl‐4‐pyridyl) porphyrin chloride (PTMPP); sinoporphyrin sodium (also known as DVDMS); indocyanine green (ICG); pentalysine β‐carbonylphthalocyanine zinc (ZnPc‐[Lys] 5 ); zinc phthalocyanine tetrasulfonate (ZnPc‐S 4 ); poly‐L‐lysine conjugate of chlorine p6 (pl‐cp6), β‐lactamase‐activated EtNBS (LAEtNBS); RLP068/Cl, toluidine blue O (TBO); polyethylenimine‐chlorin(e6) (PEI‐ce6); and poly‐ l ‐lysine‐chlorin e6 (pL‐ce6) …”

Section: Resultsmentioning

confidence: 99%

“…The photosensitisers were administered topically in 13 studies, by subcutaneous injection in one study, and by intraperitoneal injection in another study . In one study, burn wounds were simultaneously treated by both topical application and injection under the wound .…”

Section: Resultsmentioning

confidence: 99%

“…Two studies used 410‐nm light‐emitting diodes (LEDs), one study used an 808‐nm diode laser, and one study did not mention the wavelength of the light source . When visible light was used, the fluence ranged from 6 to 450 J/cm 2 , and the energy density ranged from 84 to 300 mW/cm 2 . For the 808‐nm diode laser, the fluence was 450 J/cm 2 …”

Section: Resultsmentioning

confidence: 99%

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Antimicrobial photodynamic therapy in skin wound healing: A systematic review of animal studies

Sun

Ogawa

Xiao

et al. 2019

International Wound Journal

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Bacterial infection is a common wound complication that can significantly delay healing. Classical local therapies for infected wounds are expensive and are frequently ineffective. One alternative therapy is photodynamic therapy (PDT). We conducted a systematic review to clarify whether PDT is useful for bacteria‐infected wounds in animal models. PubMed and Medline were searched for articles on PDT in infected skin wounds in animals. The language was limited to English. Nineteen articles met the inclusion criteria. The overall study methodological quality was moderate, with a low‐moderate risk of bias. The animal models were mice and rats. The wounds were excisional, burn, and abrasion wounds. Wound size ranged from 6 mm in diameter to 1.5 × 1.5 cm2. Most studies inoculated the wounds with Pseudomonas aeruginosa or methicillin‐resistant Staphylococcus aureus. Eleven and 17 studies showed that the PDT of infected wounds significantly decreased wound size and bacterial counts, respectively. Six, four, and two studies examined the effect of PDT on infected wound‐cytokine levels, wound‐healing time, and body weight, respectively. Most indicated that PDT had beneficial effects on these variables. PDT accelerated bacteria‐infected wound healing in animals by promoting wound closure and killing bacteria.

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Antimicrobial photodynamic therapy in skin wound healing: A systematic review of animal studies

Sun

Ogawa

Xiao

et al. 2019

International Wound Journal

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Nanoparticles as therapeutic options for treating multidrug-resistant bacteria: research progress, challenges, and prospects

Ifeanyi

Nweze

2021

World J Microbiol Biotechnol

186

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Resistance to antimicrobial agents has been alarming in recent years and poses a huge public health threat globally according to the WHO. The increase in morbidity and mortality resulting from microbial infections has been attributed to the emergence of multidrug-resistant microbes. Associated with the increase in multidrug resistance is the lack of new and effective antimicrobials. This has led to global initiatives to identify novel and more effective antimicrobial agents in addition to discovering novel and effective drug delivery and targeting methods. The use of nanoparticles as novel biomaterials to fully achieve this feat is currently gaining global attention. Nanoparticles could become an indispensable viable therapeutic option for treating drug-resistant infections. Of all the nanoparticles, the metals and metal oxide nanoparticles appear to offer the most promise and have attracted tremendous interest from many researchers. Moreover, the use of nanomaterials in photothermal therapy has received considerable attention over the years. This review provides current insight on antimicrobial resistance as well as the mechanisms of nanoparticle antibacterial activity. It offers an in-depth review of all the recent findings in the use of nanomaterials as agents against multi-resistant pathogenic bacteria. Also, nanomaterials that can respond to light stimuli (photothermal therapy) to kill microbes and facilitate enhanced drug delivery and release are discussed. Moreover, the synergistic interactions of nanoparticles with antibiotics and other nanomaterials, microbial adaptation strategies to nanoparticles, current challenges, and future prospects were extensively discussed.

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Photodynamic therapy for skin wound healing: the role of porphyrin type photosensitizers

Laranjo,

Alves,

Botelho

et al. 2025

Drug Delivery Systems for Wound Healing

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Enhanced sterilization and healing of cutaneous pseudomonas infection using 5-aminolevulinic acid as a photosensitizer with 410-nm LED light

Abstract: These results suggest that PDT with EDTA-2Na and ALA is a potential novel treatment option for PA-infected wounds.

Cited by 29 publications

References 43 publications

Antimicrobial photodynamic therapy in skin wound healing: A systematic review of animal studies

Antimicrobial photodynamic therapy in skin wound healing: A systematic review of animal studies

Nanoparticles as therapeutic options for treating multidrug-resistant bacteria: research progress, challenges, and prospects

Photodynamic therapy for skin wound healing: the role of porphyrin type photosensitizers

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