Enhanced survival by vitamin A supplementation during a retrovirus infection causing murine aids

Watson, Ronald R.; Yahya, M. Danial; Darban, Hamid; Prabhala, Rao

doi:10.1016/0024-3205(88)90146-4

Cited by 18 publications

(2 citation statements)

References 14 publications

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“…Studies of the effects of vitamin A status on functional immunity have not been conducted in subjects with HIV infection. Although retrovirus infection in mice has been used as a model for HIV infection (Watson et al 1988), this infection is not similar in that the virus infects both B and T lymphocytes in mice rather than CD4+ lymphocytes as it does in HIV infection.…”

Section: Human Immunodeficiency Virus Infectionmentioning

confidence: 99%

Vitamin A and immunity to viral, bacterial and protozoan infections

1999

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fax +1 410 955 0629, email rdsemba@jhmi.edu Studies in animal models and cell lines show that vitamin A and related retinoids play a major role in immunity, including expression of mucins and keratins, lymphopoiesis, apoptosis, cytokine expression, production of antibody, and the function of neutrophils, natural killer cells, monocytes or macrophages, T lymphocytes and B lymphocytes. Recent clinical trials suggest that vitamin A supplementation reduces morbidity and mortality in different infectious diseases, such as measles, diarrhoeal disease, measles-related pneumonia, human immunodeficiency virus infection and malaria. Immune responses vary considerably during different infections, and the available data suggest that the modulation of immune function by vitamin A may also vary widely, depending on the type of infection and immune responses involved.

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Section: Human Immunodeficiency Virus Infectionmentioning

confidence: 99%

Vitamin A and immunity to viral, bacterial and protozoan infections

1999

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“…Portanto, parece pelo HIV (AIDS) pode sofrer influências negativas da hipovitaminose A, sendo que este aspecto continua pouco estudado. Relato utilizando modelo de AIDS murina, demonstrou evolução desfavorável da doença nos animais alimentados com dieta deficiente em vitamina A 28 . Semba et al 19 , estudando pacientes norteamericanos com AIDS, verificaram haver associação de deficiência de vitamina A, baixos valores de linfócitos CD 4 + e maior taxa de mortalidade.…”

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Sobrevida e processos infecciosos em pacientes com AIDS: análise de acordo com os níveis séricos iniciais de vitamina A

Figueiredo

Lorenzato

Silveira

et al. 2001

Rev. Soc. Bras. Med. Trop.

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Resumo Pacientes com AIDS (n=39) foram acompanhados por um período máximo de 36 meses, após os quais se analisou os tipos e topografias das complicações infecciosas apresentadas e a sobrevida dos mesmos, correlacionado-se esses parâmetros com os níveis de vitamina A que apresentavam no início do seguimento clínico. Vinte e um (53,8%)pacientes tinham níveis de retinol no soro abaixo de 1,6µmol/L, dos quais 12 (57%) abaixo de 1,05µmol/L. Não houve associação de carência de vitamina A com os tipos ou topografias das complicações infecciosas que ocorreram durante o período de seguimento. Muito embora a sobrevida média no final dos 36 meses tenha sido semelhante nos dois grupos, os pacientes com carência de retinol apresentaram menor probabilidade de sobrevida nos primeiros 24 meses de acompanhamento (8,44 meses x 16,42 meses; p= 0,003). Palavras-chaves: AIDS. Vitamina A. Sobrevida. Infecções.Abstract Patients with AIDS (n = 39) were followed up for a maximum period of 36 weeks, after which the types and topographies of infectious complications presented and patient survival were analyzed and correlated with the vitamin A levels presented by the patients at the beginning of clinical follow-up. Twenty-one (53,8%) patients presented serum retinol levels below 1.6µmol/L, 12 (57%) of whom had values lower than 1.05µmol/L. There was no correlation between low serum vitamin A levels and the types or topographies of the infectious complications that occurred during the follow-up period. Although mean survival at the end of the 36 months follow-up period was similar for the two groups, patients with retinol deficiency presented a lower probability of survival during the first 24 months of follow-up compared to patients without hypovitaminosis A (8.44 x 1.42 months; p = 0.003).

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Enhancement of the Expression of Activation Markers on Human Peripheral Blood Mononuclear Cells by In Vitro Culture With Retinoids and Carotenoids

Prabhala¹,

Maxey

Hicks

et al. 1989

Journal of Leukocyte Biology

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Retinoids (retinol, retinal, retinoic acid, retinyl beta-glucuronide, and 13-cis retinoic acid) and carotenoids (beta-carotene and canthaxanthin) were evaluated for their immunomodulatory effects on human peripheral blood T-lymphocyte subpopulations and natural killer (NK) cells. Peripheral blood mononuclear cells (PBMC) from healthy young volunteers were isolated and incubated for 72 hours at various levels of retinoids and carotenoids including a physiological concentration (10(-8) M). Expression of surface antigens for total T cells, T-helper and T-suppressor cells, and activation markers (transferrin receptor, HLA-Dr antigen, and interleukin 2 receptor) were analyzed with an EPICS V flow cytometer. Retinoic acid and 13-cis retinoic acid (13-cRA) produced significant increases in the percentage of cells with markers for total T-helper cells, with a minimal effect on percentage of lymphocytes with markers for NK cells. However, beta-carotene (BC), canthaxanthin (CTX), and retinyl beta-glucuronide (RBG) dramatically increased the percentage of PBMC with markers for NK cells and produced a smaller increase in lymphocytes with surface antigens identifying them as T-helper cells. Furthermore, retinol and retinal did not show significant change either in the percentage of lymphocytes with markers for T-helper cells or in the helper/suppressor ratio. An increase in the expression of HLA-Dr antigen and transferrin receptors was greater when cells were incubated with 13-cRA than with either BC, CTX, or RBG, while carotenoids produced a greater increase in the expression of IL-2 receptors than 13-cRA. Our study indicates that both retinoids and carotenoids might be activating different subpopulations of immune cells.

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Enhanced survival by vitamin A supplementation during a retrovirus infection causing murine aids

Cited by 18 publications

References 14 publications

Vitamin A and immunity to viral, bacterial and protozoan infections

Vitamin A and immunity to viral, bacterial and protozoan infections

Sobrevida e processos infecciosos em pacientes com AIDS: análise de acordo com os níveis séricos iniciais de vitamina A

Enhancement of the Expression of Activation Markers on Human Peripheral Blood Mononuclear Cells by In Vitro Culture With Retinoids and Carotenoids

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