Enhanced synergism of antibiotics with zinc oxide nanoparticles against extended spectrum β-lactamase producers implicated in urinary tract infections

Bhande, Rashmi M.; Khobragade, Chandrahasya N.; Mane, Rajaram S.; Bhande, Sambhaji S.

doi:10.1007/s11051-012-1413-4

Cited by 48 publications

(36 citation statements)

References 33 publications

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“…Bhande et al [18] in his study revealed the same results where MIC values for both E. coli and K. pneumoniae were recorded as 0.08 mg/ml and 0.06 mg/ml [18]. All strains were resistant towards CIP but the combined effect of CIP with ZnO NPs showed greater microbial inhibition.…”

Section: Discussionmentioning

confidence: 62%

Antimicrobial Behavior of Zinc Oxide Nanoparticles and β-Lactam Antibiotics against Pathogenic Bacteria

Farzana¹,

Iqra²,

Shafaq³

et al. 2017

Arch Clin Microbiol

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Background: Multi-drug resistance among the pathogenic bacteria poses a serious threat to public health. Nanoparticles are one of the most effective therapeutic agents. Zinc oxide nanoparticles (ZnO NPs) are well known antimicrobial agents and are regarded as nontoxic and bio-safe. The present study aims to investigate the antimicrobial effect of ZnO NPs against the bacterial strains i.e. Klebsiella pneumoniae (K. pneumoniae) and Escherichia coli (E.coli).

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Section: Discussionmentioning

confidence: 62%

Antimicrobial Behavior of Zinc Oxide Nanoparticles and β-Lactam Antibiotics against Pathogenic Bacteria

Farzana¹,

Iqra²,

Shafaq³

et al. 2017

Arch Clin Microbiol

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“…The observed enhancement in the activity was realized against both the tested microorganisms. An improved antimicrobial effect is attributed to the synergistic interactions from the ZnO core and the released ampicillin molecules . ZnO‐generated reactive oxygen species (ROS) caused membrane disruption, which, in turn, resulted in a higher uptake of antibiotic molecules within the bacterial lumen, causing cell death .…”

Section: Resultsmentioning

confidence: 99%

“…The generated ROS subsequently results in membrane disruption and microbial cell death . When combined with conventional antibiotics, ZnO enhances the efficacy of antibiotics by several folds through permeation of the bacterial cell membrane which results in increased uptake of antibiotics . Zinc ions released during the gradual disintegration of ZnO are also speculated to possess antimicrobial properties .…”

Section: Introductionmentioning

confidence: 99%

“…[4] When combined with conventional antibiotics, ZnO enhances the efficacy of antibiotics by several folds through permeation of the bacterial cell membrane which results in increased uptake of antibiotics. [5] Zinc ions released during the gradual disintegration of ZnO are also speculated to possess antimicrobial properties. [6] On a macro-level, ZnO also inhibits the formation of protective bacterial biofilm layers and thereby increases the susceptibility of microbes towards subsequent antibiotic treatment.…”

Section: Introductionmentioning

confidence: 99%

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Synergistic Antimicrobial Activity in Ampicillin Loaded Core‐Shell ZnO@ZIF‐8 Particles

et al. 2019

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Combination therapy with the use of nanomaterials and antibiotics is an effective approach to combat increasing antimicrobial resistance. Herein, the synthesis and antimicrobial activity of core‐shell Zinc oxide ‐ Zeolitic Imidazolate Framework‐8 (ZnO@ZIF‐8) particles loaded with ampicillin is reported. The efficacy of the above system has been evaluated against Gram‐negative Escherichia coli (E. coli) and Gram‐positive Staphylococcus aureus (S. aureus) strains. The entrapment of ampicillin within the ZIF‐8 shell of the particles allowed its controlled and pH‐responsive release under in vitro conditions. Ampicillin loaded ZnO@ZIF‐8 particles have exhibited enhanced antimicrobial activity as reflected by the minimum inhibitory concentration (MIC) values of 12.50 and 48 μg mL−1 against E. coli and S. aureus, respectively. This was also evident by a several‐fold reduction observed in the bacterial population during the time‐kill assays. The values of fractional inhibitory concentration indices (FICI), assessed for different components, have revealed the ZnO@ZIF‐8/ampicillin system inflicts a synergistic activity against E. coli and an additive activity against S. aureus. Cell membrane disruption is attributed to cell death. Finally, cytotoxicity study against mammalian cell lines has indicated the safety profiles of the particles.

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“…Recently, Bhande et al, 2013) have demonstrated that antibiotics showed enhanced synergism with ZnO nanoparticles against extended spectrum-lactamases producers implicated in urinary tract infections. In their work, they proposed that the combination of ZnO nanoparticle and antibiotic increased the permeability of membrane which resulted in the leakage of protein from the membrane of bacteria.…”

Section: Antibacterial Assaymentioning

confidence: 99%

Biophysical and Characterizations of Silver Nanoparticles used as Salmonella typhi Detector

Ahmed

2014

Int J Appl Sci Biotechnol

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The present study mainly focuses of combined action of Nepali hog plum as well as citrate synthesized silver nanoparticles (AgNPs) and Amikacin, as an antibiotic. The synergistic actions of citrate stabilized silver nanoparticles (AgNPs with chem) were compared with that of Nepali hog plum Choerospondia saxillaris (Lapsi) synthesized silver nanoparticles (AgNPs with plant), together with action of antibiotic on selected bacterial strains of Salmonella typhi.The synthesized AgNPs were characterized through UV-Vis spectroscopy, Transmission electron microscopy and X-ray diffraction technique. The size of the synthesized silver nanoparticles was measured by Transmission Electron Microscope (TEM) and X-ray diffraction (XRD).

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Enhanced synergism of antibiotics with zinc oxide nanoparticles against extended spectrum β-lactamase producers implicated in urinary tract infections

Cited by 48 publications

References 33 publications

Antimicrobial Behavior of Zinc Oxide Nanoparticles and β-Lactam Antibiotics against Pathogenic Bacteria

Antimicrobial Behavior of Zinc Oxide Nanoparticles and β-Lactam Antibiotics against Pathogenic Bacteria

Synergistic Antimicrobial Activity in Ampicillin Loaded Core‐Shell ZnO@ZIF‐8 Particles

Biophysical and Characterizations of Silver Nanoparticles used as Salmonella typhi Detector

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