Enhanced Tb(III) fluorescence on gelatin-coated silver nanoparticles in dopamine detection

Sun, Jia; Feng, Aili; Wu, Xia; Che, Xiaowen; Zhou, Weizhi

doi:10.1016/j.talanta.2021.122334

Cited by 15 publications

(8 citation statements)

References 45 publications

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“…For catecholamine interferences, such as epinephrine (EP) and noradrenaline (NE), their concentrations in body fluids were much lower than DA. The concentration of norepinephrine in serum was less than one-tenth of the concentration of DA. − Also, Figure C shows that EP and NE had little interference with DA detection, as reported previously. , In conclusion, GNC–Ce 3+ showed excellent selectivity.…”

Section: Resultssupporting

confidence: 76%

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Tyrosine-Decorated Gold Nanoclusters Chelated Cerium(III) for Fluorescence Detection of Dopamine

Zhu

Weng

et al. 2021

ACS Appl. Nano Mater.

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In this work, a tyrosine-decorated gold nanocluster (Tyr-GNC)–cerium(III) complex was established for the fluorescent detection of dopamine (DA). Tris–HCl buffer was used for synthesizing Tyr-GNC; thus, Tyr-GNC could emit fluorescence even under neutral conditions. The quantum yield (QY) of Tyr-GNC was 13.3%. Trivalent cerium ions (Ce3+) chelated hydroxyl and amino groups of tyrosine to form GNC–Ce3+. Also, DA showed a higher quenching efficiency in the fluorescence of GNC–Ce3+ than that of GNC. The mechanism was that Ce3+ chelated with DA and promoted its oxidative self-aggregation under alkaline buffer, and, at the same time, the oxidative product quenched the fluorescence of Tyr-GNC by the inner filter effect (IFE). In DA detection, GNC–Ce3+ showed a wide detection range (0.1–1000 μM) and a low detection limit (10.85 nM) for DA with high selectivity. The platform was successfully applied to DA detection in human plasma. This work proposed insight into the interaction between GNC–Ce3+ and DA, which has broad application prospects in clinical diagnosis.

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Section: Resultssupporting

confidence: 76%

“…65−67 Also, Figure 7C shows that EP and NE had little interference with DA detection, as reported previously. 60,68 In conclusion, GNC−Ce 3+ showed excellent selectivity.…”

Section: ■ Results and Discussionmentioning

confidence: 76%

Tyrosine-Decorated Gold Nanoclusters Chelated Cerium(III) for Fluorescence Detection of Dopamine

Zhu

Weng

et al. 2021

ACS Appl. Nano Mater.

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“…The fragment pattern, characterized by the m / z ratios of the precursor ion and fragment ions, is as unique as a fingerprint for each molecule [ 54 ] and enables us to specifically identify our targeted analytes, rather than using retention times only. Other types of detection, such as quantification by fluorescent dyes [ 35 , 36 , 37 ], are less specific than the method described herein. Neurotransmitter quantification by HPLC with fluorescence detection is also both less specific and less sensitive, since it is necessary to derivatize the analytes into a fluorescent product.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, neurotransmitters display poor stability. Methods do already exist to quantify neurotransmitters in a variety of matrices by electrochemical detection [ 31 , 32 ], fluorescence detection [ 33 , 34 ] or fluorescent dyes [ 35 , 36 , 37 ]. However, here, we opted for liquid chromatography–tandem mass spectrometry (LC-MS/MS) as the preferred choice due to its high sensitivity and unmatched specificity, and given its propensity to detect distinctive mass transitions of each analyte, and therefore, its capacity for unequivocal identification.…”

Section: Introductionmentioning

confidence: 99%

A Reliable Method Based on Liquid Chromatography–Tandem Mass Spectrometry for the Simultaneous Quantification of Neurotransmitters in Caenorhabditis elegans

Weishaupt,

Kubens,

Ruecker

et al. 2023

Molecules

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Neurotransmitters like dopamine (DA), serotonin (SRT), γ-aminobutyric acid (GABA) and acetylcholine (ACh) are messenger molecules that play a pivotal role in transmitting excitation between neurons across chemical synapses, thus enabling complex processes in the central nervous system (CNS). Balance in neurotransmitter homeostasis is essential, and altered neurotransmitter levels are associated with various neurological disorders, e.g., loss of dopaminergic neurons (Parkinson’s disease) or altered ACh synthesis (Alzheimer’s disease). Therefore, it is crucial to possess adequate tools to assess precise neurotransmitter levels, and to apply targeted therapies. An established in vivo model to study neurotoxicity is the model organism Caenorhabditis elegans (C. elegans), as its neurons have been well characterized and functionally are analogous to mammals. We have developed a liquid chromatography–tandem mass spectrometry (LC-MS/MS) method including a sample preparation assuring neurotransmitter stability, which allows a simultaneous neurotransmitter quantification of DA, SRT, GABA and ACh in C. elegans, but can easily be applied to other matrices. LC-MS/MS combined with isotope-labeled standards is the tool of choice, due to its otherwise unattainable sensitivity and specificity. Using C. elegans together with our analytically validated and verified method provides a powerful tool to evaluate mechanisms of neurotoxicity, and furthermore to identify possible therapeutic approaches.

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“…Owing to the LSPR phenomenon, comparing with the sensor based on an AgNPs-free MIP sensor chip, the detection limit of this method is reduced by 33 times, and the overall value of sensor response is significantly increased. Sun et al [17] developed a composite fluorescent nanoprobe for the selective and sensitive detection of dopamine based on the metal-enhanced fluorescence effect of gelatin-coated Ag nanoparticles, and a significant fluorescence enhancement effect is achieved.…”

Section: Introductionmentioning

confidence: 99%

A novel natural surface-enhanced fluorescence system based on reed leaf as substrate for crystal violet trace detection

Cao

et al. 2022

Chinese Phys. B

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The preparation of surface-enhanced fluorescence (SEF) substrates is often influenced by experimental strategies and factors such as the morphology and size of the nanostructures. In this study, using the natural reed leaves (R.L.) without any special pretreatment as the substrate, metal silver was modified by magnetron sputtering technology to prepare a stable and efficient SEF system. The abundant “hedgehog-like” protrusions on R.L. substrate surface can generate high-density “hot spots”, enhancement factor (EF) is up to 3345 times, and stability and reproducibility have been verified in many measurements. The contribution of the intervention of silver nanostructure to the radiation attenuation process of fluorescent molecules is analyzed with the aid of Jablonski diagrams. 3D finite difference time domain (FDTD) simulate the spatial electric field and “hot spots” distribution of the substrate, “hedgehog-like” protrusions structure generate multiple “hot spots”, which produce an excellent local surface plasmon resonance (LSPR) effect and provide higher fluorescence signal. Finally, R.L./Ag-35 substrate is used to detect crystal violet (CV), the detection limit is as low as 10-13 M, and this “hedgehog-like” SEF substrate provides a new strategy for the trace detection of CV has good practical application value.

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Enhanced Tb(III) fluorescence on gelatin-coated silver nanoparticles in dopamine detection

Cited by 15 publications

References 45 publications

Tyrosine-Decorated Gold Nanoclusters Chelated Cerium(III) for Fluorescence Detection of Dopamine

Tyrosine-Decorated Gold Nanoclusters Chelated Cerium(III) for Fluorescence Detection of Dopamine

A Reliable Method Based on Liquid Chromatography–Tandem Mass Spectrometry for the Simultaneous Quantification of Neurotransmitters in Caenorhabditis elegans

A novel natural surface-enhanced fluorescence system based on reed leaf as substrate for crystal violet trace detection

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