Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

Kizu, Junko; Arakawa, Motoki; Arakawa, Yoshihiro; Komoda, Fusako; Takamizawa, Masaru; Iwata, Tadahisa; Hayakawa, Tetsuo; Imai, Kazuhiro

doi:10.1002/(sici)1099-0801(199911)13:7<462::aid-bmc912>3.0.co;2-p

Cited by 2 publications

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“…17,18,20,21 The second approach is the identification of the various platinum species. Usually, LC separation is combined with element-specific detection, such as FAAS, 13,22 inductively coupled plasma atomic emission spectrometry (ICP-AES), 23 UV detection, [24][25][26] nuclear and electrochemical detection, 27,28 as well as ICP-MS. [29][30][31][32][33] However, none of these techniques can provide useful structural information on the intact drug or its metabolites. Such information can be obtained by 195 Pt or 15 N or 1 H NMR spectrometry, [34][35][36] but at least several milligrams of material are required for NMR.…”

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confidence: 99%

Electrospray ionization mass spectrometry coupled to liquid chromatography for detection of cisplatin and its hydrated complexes

Cui

Mester

2003

Rapid Comm Mass Spectrometry

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Electrospray ionization mass spectrometry (ESI-MS) coupled to liquid chromatography (LC) has been applied to investigate cisplatin and its hydrated complexes. Three hydrolysis products were identified following incubation of cisplatin in aqueous solution: monohydrated species, dihydrated species and the hydroxo-bridged dimer, each of which exhibited characteristic mass spectrometric behavior. The technique was employed to investigate the time- and pH-dependent hydrolysis of cisplatin in aqueous solution. The results have demonstrated that LC/ESI-MS is a powerful technique for the analysis of Pt(II) complexes and for monitoring their hydrolysis reactions.

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confidence: 99%

Electrospray ionization mass spectrometry coupled to liquid chromatography for detection of cisplatin and its hydrated complexes

Cui

Mester

2003

Rapid Comm Mass Spectrometry

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“…19) In addition, Vestal and colleagues found that TP clearance is higher in young people than in the elderly because of a decline in TP metabolite formation. [20][21][22] Furthermore, we analyzed our previous data in humans 5,6,23) and found that the DMU/TP ratio was highest at 0.063 ± 0.013 in patients aged 1-4 years, decreased to 0.055 ± 0.012 in patients aged 13-55 years, and decreased further to 0.041 ± 0.023 in patients aged 56-86 years. These data suggest that the effects of age on TP metabolism in humans may be evaluated using the DMU/TP ratio.…”

Section: Detection Of Tp and Its Metabolites In Mouse Serummentioning

confidence: 99%

Age-Associated Theophylline Metabolic Activity Corresponds to the Ratio of 1,3-Dimethyluric Acid to Theophylline in Mice

Kuroda

Taguchi

Enoki

et al. 2019

Biological & Pharmaceutical Bulletin

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Age is known as one of influencing factor for theophylline (TP)-metabolizing capacity. In a previous our study, the ratio of TP and its major metabolite 1,3-dimethyluric acid (DMU) in serum (DMU/TP) is a useful index to estimate TP-metabolizing capacity, and this value markedly increased by influencing factor, such as the history of smoking. However, it is unknown whether DMU/TP values in serum reflect age-associated changes of TP-metabolizing capacity. In this study, the effect of age on the DMU/TP values in serum were investigated using mice of different age due to the limited blood sampling in human. The concentrations of TP and its metabolites in mouse serum were simultaneously measured using HPLC. As observed in human serum, serum TP concentrations were closely correlated with DMU concentration in mice, which indicates that the DMU/TP ratio is a good indicator of TP metabolic ability in mice. When TP was administered subcutaneously in 2-28-week-old mice, age-associated changes in the DMU/TP ratio in mice were observed. In conclusion, age-associated changes in TP-metabolizing capacity can be estimated by the DMU/TP ratio in serum.

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Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

Cited by 2 publications

References 5 publications

Electrospray ionization mass spectrometry coupled to liquid chromatography for detection of cisplatin and its hydrated complexes

Electrospray ionization mass spectrometry coupled to liquid chromatography for detection of cisplatin and its hydrated complexes

Age-Associated Theophylline Metabolic Activity Corresponds to the Ratio of 1,3-Dimethyluric Acid to Theophylline in Mice

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