1987
DOI: 10.1128/aac.31.7.986
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Enhanced therapeutic efficacy of poly(ICLC) and ribavirin combinations against Rift Valley fever virus infection in mice

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Cited by 41 publications
(26 citation statements)
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“…In rodents and primates, poly(IC ⅐ LC) has been shown to be effective in providing protection against a number of viral infections, including those caused by yellow fever (11), Venezuelan equine encephalomyelitis (10), Rift Valley fever (5), and rabies (1) viruses. The antiviral activity of poly (IC ⅐ LC) is believed to be mediated by its ability to augment the production of alpha, beta, and gamma interferons in vivo (5,7,8) and to stimulate specific components of the cellular and humoral immune systems, including the activation of natural killer cells (2,12). The antiviral potential of poly(IC ⅐ LC) for the prevention and treatment of respiratory influenza A virus infection in mice was evaluated in the present study.…”
mentioning
confidence: 99%
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“…In rodents and primates, poly(IC ⅐ LC) has been shown to be effective in providing protection against a number of viral infections, including those caused by yellow fever (11), Venezuelan equine encephalomyelitis (10), Rift Valley fever (5), and rabies (1) viruses. The antiviral activity of poly (IC ⅐ LC) is believed to be mediated by its ability to augment the production of alpha, beta, and gamma interferons in vivo (5,7,8) and to stimulate specific components of the cellular and humoral immune systems, including the activation of natural killer cells (2,12). The antiviral potential of poly(IC ⅐ LC) for the prevention and treatment of respiratory influenza A virus infection in mice was evaluated in the present study.…”
mentioning
confidence: 99%
“…The ability of poly(IC ⅐ LC) to modulate the immune responses including interferon induction (5,7,8) and activation of natural killer cells (2, 12) may present many advantages for influenza prophylaxis. The antiviral activity of interferons and/or activation of natural killer cells induced by poly (IC ⅐ LC) may result in a nonspecific antiviral defense against a number of viral agents and may therefore provide a broadspectrum antiviral effect against influenza viruses, regardless of the strain or subtype involved.…”
mentioning
confidence: 99%
“…2 -' 2 According to their origin, these substances can be classified into four groups, although the classification is not always clear-cut (TABLE 3): (1) synthetic compounds or chemicals, (2) microbial or natural products, (3) regulatory, biological substances, and (4) thymic hormones. With the exception of thymic hormones, about 60 of the listed substances were evaluated in animal models against arboviruses and to a lesser extent against herpesviruses containing RNA or DNA, respectively.…”
Section: Methodsmentioning
confidence: 99%
“…Poly IC, when complexed with LC, was found to be more nuclease resistant and was more potent inducer of inteferons in monkeys and man compared to plain Poly IC [13,14]. Poly ICLC has been shown in animal studies to be effective in providing protection against a range of infectious viruses including those causing yellow fever, Rift Valley fever, rabies and Venezuelan equine encephalomyelitis [14,15]. The antiviral activity of this complex is believed to be mediated by the ability of dsRNA to stimulate the production of , , and -interferons in vivo and to stimulate specific components of the cellular and humoral immune systems, including the activation of natural killer cells [13,16], TLR-3, PKR, OAS, RIG-I, MDA5 and others.…”
Section: The Antiviral Role Of Tlr-3 Agonistsmentioning
confidence: 97%