“…Poly IC, when complexed with LC, was found to be more nuclease resistant and was more potent inducer of inteferons in monkeys and man compared to plain Poly IC [13,14]. Poly ICLC has been shown in animal studies to be effective in providing protection against a range of infectious viruses including those causing yellow fever, Rift Valley fever, rabies and Venezuelan equine encephalomyelitis [14,15]. The antiviral activity of this complex is believed to be mediated by the ability of dsRNA to stimulate the production of , , and -interferons in vivo and to stimulate specific components of the cellular and humoral immune systems, including the activation of natural killer cells [13,16], TLR-3, PKR, OAS, RIG-I, MDA5 and others.…”