2024
DOI: 10.1088/1361-6528/ad61f2
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Enhanced therapeutic impact of Shikonin-encapsulated exosomes in the inhibition of colorectal cancer progression

Yuchang Lu,
Hailun Zhou,
Changpeng Han
et al.

Abstract: Background: Colorectal cancer (CRC) is a prevalent malignancy with high mortality rates and poor prognosis. Shikonin (SHK) has demonstrated extensive anti-tumor activity across various cancers, yet its clinical application is hindered by poor solubility, limited bioavailability, and high toxicity. This study aims to develop SHK-loaded exosomes (SHK-Exos) and assess their efficacy in CRC progression.
Materials and Methods: Exosomes were isolated using ultracentrifugation and characterized via TEM, NTA, … Show more

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