Enhanced Thermal Stability of Polylactide by Terminal Conjugation Groups

Tran, Hang Thi; Matsusaki, Michiya; Akashi, Mitsuru; Vu, Ngo Dinh

doi:10.1007/s11664-015-4329-9

Cited by 6 publications

(1 citation statement)

References 30 publications

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“…Another potential way to improve the copolymer thermal stability would be to terminally conjugate the copolymer with acid. Recently, Tran et al reported that aliphatic or carboxylic fatty or aromatic acids can be successfully conjugated into the ending hydroxyl group of PLLA and significantly improve the polymer thermal stability while retaining its crystallinity and solubility …”

Section: Discussionmentioning

confidence: 99%

Evaluation of polycaprolactone − poly-D,L-lactide copolymer as biomaterial for breast tissue engineering

et al. 2016

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The potential of the copolymer polycaprolactone‐co‐poly‐d,l‐lactic acid (PCLLA) as a biomaterial for scaffold‐based therapy for breast tissue engineering applications was assessed. First, the synthesized PCLLA was evaluated for its processability by means of additive manufacturing (AM). We found that the synthesized PCLLA could be fabricated into scaffolds with an overall gross morphology and porosity similar to that of polycaprolactone. The PCLLA scaffolds possessed a compressive Young's modulus (ca 46 kPa) similar to that of native breast (0.5 − 25 kPa), but lacked thermal stability and underwent thermal degradation during the fabrication process. The PCLLA scaffolds underwent rapid degradation in vitro which was characterized by loss of the scaffolds' mechanical integrity and a drastic decrease in mass‐average molar mass (Mw) and number‐average molar mass (Mn) after 4 weeks of immersion in phosphate buffer solution maintained at 37 °C. The tin‐catalysed PCLLA scaffold was also found to have cytotoxic effects on cells. Although the initial mechanical properties of the PCLLA scaffolds generally showed potential for applications in breast tissue regeneration, the thermal stability of the copolymer for AM processes, biocompatibility towards cells and degradation rate is not satisfactory at this stage. Therefore, we conclude that research efforts should be geared towards fine‐tuning the copolymer synthesizing methods. © 2016 Society of Chemical Industry

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Section: Discussionmentioning

confidence: 99%

Evaluation of polycaprolactone − poly-D,L-lactide copolymer as biomaterial for breast tissue engineering

et al. 2016

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Regulation of the mechanical properties and heat resistance of the poly(l‐lactide‐co‐trimethylene carbonate) copolymer by the incorporation of a stereocomplex crystal and graphene oxide

Tian

et al. 2017

J of Applied Polymer Sci

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Stereocomplex crystals of polylactide and graphene oxide (GO) were simultaneously used to regulate the mechanical properties and heat resistance of a poly(L-lactide-co-trimethylene carbonate) [P(LLA-co-TMC)] copolymer. The crystallization behaviors in the nonisothermal cold-crystallization process of P(LLA-co-TMC)-poly(D-lactide) (PDLA) blends and P(LLA-co-TMC)-PDLA-GO composites were investigated by differential scanning calorimetry, wide-angle X-ray diffraction, and polarized optical microscopy. Data from the crystallization kinetics and the crystallization active energy indicated that GO both promoted nucleation and limited growth during the stereocomplex crystallization process. Three kind of samples (without crystallization, with low crystallinity, and with high crystallinity) were used to investigate the mechanical properties and heat resistance. We found a decrease in the elongation at break when the stereocomplex crystal and GO contents were increased, and this was accompanied by an improvement in the tensile strength. The change in the storage modulus value determined by dynamic mechanical analysis demonstrated that both the stereocomplex crystal and GO effectively improved the heat resistance. These results indicate that this study provided a new strategy for fabricating a P(LLA-co-TMC) copolymer with good comprehensive properties at was entirely different from common chemical crosslinking methods.

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Investigating the crystallization, melting behavior, and thermal stability of poly(l-lactic acid) using aromatic isoniazid derivative as nucleating agent

2017

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Enhanced Thermal Stability of Polylactide by Terminal Conjugation Groups

Cited by 6 publications

References 30 publications

Evaluation of polycaprolactone − poly-D,L-lactide copolymer as biomaterial for breast tissue engineering

Evaluation of polycaprolactone − poly-D,L-lactide copolymer as biomaterial for breast tissue engineering

Regulation of the mechanical properties and heat resistance of the poly(l‐lactide‐co‐trimethylene carbonate) copolymer by the incorporation of a stereocomplex crystal and graphene oxide

Investigating the crystallization, melting behavior, and thermal stability of poly(l-lactic acid) using aromatic isoniazid derivative as nucleating agent

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