Enhanced Toxicity of Ozone-Hydrogen Peroxide Mixtures

Safety Assessment of Hydrogen Peroxide as Used in Cosmetics

“…Hydrogen Peroxide by inhalation was >16.1 ppm (only test dose; calculated as 23 mg/m 3 ). 39 In rats exposed to vapor-phase Hydrogen Peroxide in a nose-only apparatus for 2 h, there were no changes observed in light microscopy at 0.014 and 0.025 mg/m 3 ; however, electron microscopy revealed an increase in the number of neutrophils in capillary spaces adjacent to terminal respiratory bronchioles and in alveolar ducts in lungs from rats after inhalation of 0.025 mg/m 3 . 41 In one study in which rats were exposed to Hydrogen Peroxide vapors for 4 h, the median lethal concentration (LC 50 ) was 2000 mg/m 3 , the lowest-observed-effective-concentration (LOEC) for respiratory mucosa effects was 60 mg/m 3 , and the LOEC for skin effects (moderate hyperemia and transient thickening because of oxygen bubbles in skin) was 110 mg/m 3 .…”

“…Hydrogen Peroxide by inhalation was >16.1 ppm (only test dose; calculated as 23 mg/m 3 ). 39 In rats exposed to vapor-phase Hydrogen Peroxide in a nose-only apparatus for 2 h, there were no changes observed in light microscopy at 0.014 and 0.025 mg/m 3 ; however, electron microscopy revealed an increase in the number of neutrophils in capillary spaces…”

“…33 One study reported the lethal dose for mice to be >16.1 ppm (calculated as 23 mg/m 3 ; only test dose) Hydrogen Peroxide (90% aq.) when exposed for 4 h. 39 In mice, concentrations of 3600 to 5200 mg/m 3 Hydrogen Peroxide (90% aq. ), there was no mortality, but congestion of lungs and necrosis of bronchial epithelium were observed; at 9400 mg/ m 3 , lethal range (LC LO ) was reached with death occurring 6 days following exposure.…”