Enhanced toxicity of triphenyl phosphate to zebrafish in the presence of micro- and nano-plastics

He, Jing; Yang, Xianhai; Liu, Huihui

doi:10.1016/j.scitotenv.2020.143986

Cited by 54 publications

(25 citation statements)

References 43 publications

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“…As an emerging pollutant, nanoplastics have attracted more and more attention for their potential toxicity to aquatic organisms and mammals (Prata et al 2020). PS-NPs aggravated the endocrine disrupting effect of triphenyl phosphate (TPhP) in zebra sh (He et al 2021) and increased the developmental toxicity of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) (Wang et al 2022), also able to increase (synergistically) heavy metal toxicity in sh (Santos et al 2022). Many studies have detected the adsorption and accumulation of chemical pollutants on MPs in the surrounding environment, but relatively speaking, the more important toxicity mechanism of NPs is chemical toxicity (Machado et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Polystyrene nanoplastic exposure enhances LPS-induced lung inflammation in mice by inducing M1 polarization of macrophages via ROS/JAK/STAT signaling pathway

Fan

Peng

et al. 2022

Preprint

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Nanoplastics (NPs) are an emerging environmental pollutant. NPs can spike various tissues results to oxidative stress and tissue damage in organisms. While recent studies have reported a relationship between nanoparticles and respiratory system injury, the specific mechanism of NP exposure-induced lung damage remains to be explored. In the present study, C57BL6 male mice were treated intraperitoneal injection of PS-NPs and/or LPS. The relevant indicators were detected by HE staining, western blotting and qRT-PCR. RAW264.7 was pretreated with JAK2 inhibitor (AG490) to verify whether the JAK2/STAT3 signaling pathway is involved in PS-NPs exposure enhances LPS-induced pulmonary inflammatory response. We found decreased antioxidant capacity in mice lungs, activation of the JAK2/STAT3 pathway, and the expression levels of macrophage M1 marker genes increased (including CD16, CD86, and MCP1), while macrophage M2 marker genes (including CD206, PPARγ, and Arg1) expression levels decreased, resulting in a macrophage M1/M2 imbalance. In addition, PS-NPs can increase the expression of inflammation-related factors IL-1β, TNF-α and IL-6. In in vitro experiments, we obtained similar results to in vivo experiments. More importantly, the JAK2 pathway inhibitor AG490 reversed ROS-induced changes in macrophage imbalance and inflammation in PS-NPs and LPS-exposed RAW264.7 cells. In conclusion, PS-NPs activated the ROS/JAK/STAT pathway, aggravated LPS-induced lung M1/M2 macrophage imbalance and promoted inflammatory responses. Our results enrich the toxic effects and related molecular mechanisms of NPs-induced lung inflammation, and provide new insights into the toxic effects of NPs on mammals.

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Section: Discussionmentioning

confidence: 99%

Polystyrene nanoplastic exposure enhances LPS-induced lung inflammation in mice by inducing M1 polarization of macrophages via ROS/JAK/STAT signaling pathway

Fan

Peng

et al. 2022

Preprint

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“…While it is unknown if these compounds leak straight into living tissues, some additives like Bisphenol A have been discovered to be consumed by marine biota (Chen et al, 2020;Koelmans et al, 2014), Absorption of this leachate frequently used in lining food and beverage cans, can induce endocrine problems and adversely affect human health (Ryan, 2015). In particular, associated health risks may include, cytotoxicity (Gopinath et al, 2021), neurotoxicity (Han et al, 2021;Varsou et al, 2021), immunotoxicity, reproductive toxicity (He et al, 2021), or even carcinogenicity (Gao et al, 2021). Yip et al (2022) have tested and predicted the possibility of MNPs transfer from mother to offspring.…”

Section: On Living Organismsmentioning

confidence: 99%

Microplastics and Nano-Plastics: From Initiation to Termination

Awolesi¹,

Oni²,

Arwenyo³

2023

GEP

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Following the advent of the Industrial Revolution, plastic pollution has been a serious environmental issue while micro-and nano-plastics have been a cynosure of researchers' attention in the twenty-first century. This is due to the improved knowledge of its ecotoxicological effects and the global pushforward towards sustainability. There is a growing concern that the increasing presence of microplastics and nanoplastics (MNPs) in aquatic habitats poses a threat to marine life, and it is predicted that nanoplastics will be just as ubiquitous as macro-and micro-plastics, but far more destructive to living organisms due to their ability to infiltrate cells. Recent research has shown that marine and freshwater biota become entangled with plastic litter, which disrupts the ecosystem. Aquatic creatures are known to absorb and deposit these new pollutants in their digestive systems, as has been documented in several studies. More recent research has also examined their co-occurrence and toxicity with other emerging contaminants, including their prevalence and effects in food, air, and soil. Using articles extracted from a six-year period from Scopus, ACS Publications and Google Scholar, this review explores the origins, fates, occurrence in the food chain, exposure routes, cellular interactions of microplastics and nano-plastics, in addition to the ecotoxicological impacts, analytical methods, and the potential remedies for combating pollution and toxicity. Ultimately, this review is a comprehensive, updated addendum to available reviews on micro-and nano-plastics.

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“…Figure 1 illustrates the potential impact of nano-plastics in drinking water on human health. Figure 1: Illustration of impact of nano-plastics in drinking water on human health [30][31][32].…”

Section: Introductionmentioning

confidence: 99%