Enhanced transcription of pancreatic peptide YY by 1α-hydroxyvitamin D3 administration in streptozotocin-induced diabetic mice

Ozeki, Jun; Choi, Mihwa; Endo-Umeda, Kaori; Sakurai, Kenichi; Amano, Sadao; Makishima, Makoto

doi:10.1016/j.npep.2013.07.002

Cited by 7 publications

(8 citation statements)

References 33 publications

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“…It is noteworthy that our results obtained from publicly available data sets also showed a trend toward a reduction in VDR expression in human islets from T2D patients. These results were consistent with previous reports showing a reduction in Vdr expression in pancreas from STZ-treated mice and rats (17). In this work, we provided evidence that Vdr reduction also occurs in islets from NOD mice that spontaneously develop diabetes and share many features with human T1D (33).…”

Section: Discussionsupporting

confidence: 93%

“…In accordance with this, we observed a decrease in insulin gene expression levels parallel to Vdr reduction in islets from diabetic mice. Moreover, treatment with vitamin D increased Ins1 mRNA expression in control animals, but this effect was lost in STZ-treated mice, possibly because of a decrease in Vdr expression in islets (17). These results suggest that VDR may be involved in Ins1 transcription in mouse pancreas (17).…”

Section: Discussionmentioning

confidence: 80%

“…Pancreatic islets also express VDR and can metabolize inactive 25-hydroxyvitamin D3 to active 1,25 (OH)2D3 (17). Vitamin D has been reported to exert beneficial effects on glucose tolerance enhancing b-cell function (18,19).…”

mentioning

confidence: 99%

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Vitamin D Receptor Overexpression in β-Cells Ameliorates Diabetes in Mice

et al. 2020

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Vitamin D deficiency has been associated with increased incidence of diabetes, both in humans and in animal models. In addition, an association between vitamin D receptor (VDR) gene polymorphisms and diabetes has also been described. However, the involvement of VDR in the development of diabetes, specifically in pancreatic β-cells, has not been elucidated yet. Here, we aimed to study the role of VDR in β-cells in the pathophysiology of diabetes. Our results indicate that Vdr expression was modulated by glucose in healthy islets and decreased in islets from both type 1 diabetes and type 2 diabetes mouse models. In addition, transgenic mice overexpressing VDR in β-cells were protected against streptozotocin-induced diabetes and presented a preserved β-cell mass and a reduction in islet inflammation. Altogether, these results suggest that sustained VDR levels in β-cells may preserve β-cell mass and β-cell function and protect against diabetes.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 80%

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Vitamin D Receptor Overexpression in β-Cells Ameliorates Diabetes in Mice

et al. 2020

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“…CYP24A1 encodes vitamin D 24-hydroxylase and is the VDR target that is induced by VDR activation in many of the VDR-expressing cells [ 16 ]. We treated mice with 1,25(OH) 2 D 3 (15 or 50 nmol/kg) or LCA (0.3 or 0.8 mmol/kg) by oral gavage twice (14 and 2 h before euthanization), according to our previous reports, with minor modification [ 9 , 16 , 18 ], and compared the effect of these compounds on CYP24A1 mRNA expression in the duodenum, jejunum, and ileum. The 1,25(OH) 2 D 3 treatment increased the Cyp24a1 mRNA levels in the duodenum, jejunum, and ileum ( Figure 1 A).…”

Section: Resultsmentioning

confidence: 99%

“…The experiments were conducted with male mice at 8–12 weeks of age. The mice were treated with corn oil containing the vehicle control (ethanol; Kanto Chemical Co., Tokyo, Japan), 1,25(OH) 2 D 3 (15 or 50 nmol/kg; Wako Pure Chemicals, Osaka, Japan), or LCA (0.3 or 0.8 mmol/kg; Nacalai Tesque, Kyoto, Japan) via oral gavage, twice (14 and 2 h before euthanization), as reported previously, with minor modifications [ 9 , 16 , 18 ]. The plasma, kidney, and intestine samples were collected after euthanization with carbon dioxide.…”

Section: Methodsmentioning

confidence: 99%

Lithocholic Acid Is a Vitamin D Receptor Ligand That Acts Preferentially in the Ileum

Ishizawa

Akagi

Makishima

2018

IJMS

Self Cite

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The vitamin D receptor (VDR) is a nuclear receptor that mediates the biological action of the active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], and regulates calcium and bone metabolism. Lithocholic acid (LCA), which is a secondary bile acid produced by intestinal bacteria, acts as an additional physiological VDR ligand. Despite recent progress, however, the physiological function of the LCA−VDR axis remains unclear. In this study, in order to elucidate the differences in VDR action induced by 1,25(OH)2D3 and LCA, we compared their effect on the VDR target gene induction in the intestine of mice. While the oral administration of 1,25(OH)2D3 induced the Cyp24a1 expression effectively in the duodenum and jejunum, the LCA increased target gene expression in the ileum as effectively as 1,25(OH)2D3. 1,25(OH)2D3, but not LCA, increased the expression of the calcium transporter gene Trpv6 in the upper intestine, and increased the plasma calcium levels. Although LCA could induce an ileal Cyp24a1 expression as well as 1,25(OH)2D3, the oral LCA administration was not effective in the VDR target gene induction in the kidney. No effect of LCA on the ileal Cyp24a1 expression was observed in the VDR-null mice. Thus, the results indicate that LCA is a selective VDR ligand acting in the lower intestine, particularly the ileum. LCA may be a signaling molecule, which links intestinal bacteria and host VDR function.

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The Physiological Importance of Bile Acid Structure and Composition on Glucose Homeostasis

Higuchi

2020

Curr Diab Rep

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Enhanced transcription of pancreatic peptide YY by 1α-hydroxyvitamin D3 administration in streptozotocin-induced diabetic mice

Cited by 7 publications

References 33 publications

Vitamin D Receptor Overexpression in β-Cells Ameliorates Diabetes in Mice

Vitamin D Receptor Overexpression in β-Cells Ameliorates Diabetes in Mice

Lithocholic Acid Is a Vitamin D Receptor Ligand That Acts Preferentially in the Ileum

The Physiological Importance of Bile Acid Structure and Composition on Glucose Homeostasis

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