Enhanced transdermal delivery of salbutamol sulfate via ethosomes

Bendas, Ehab R.; Tadros, Mina Ibrahim

doi:10.1208/pt0804107

Cited by 127 publications

(91 citation statements)

References 32 publications

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“…Then, this leads to the increase in permeability of the stratum corneum to the drug. 21 The EGCG entrapped in ethosome, containing phospholipid (having the same structure with the lipid bilayer skin) and ethanol (causing the fluidity of vesicles), was another reason for increasing of EGCG penetrated. 11 The vesicles that were formulated into a gel dosage form can be a controlled release delivery.…”

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confidence: 99%

Novel Transdermal Ethosomal Gel Containing Green Tea (Camellia sinensis L. Kuntze) Leaves Extract: Formulation and In vitro Penetration Study

Ramadon¹,

Wirarti²,

Anwar³

2017

JYP

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Background: One of the natural products that have many benefits is green tea (Camellia sinensis L.). It can be used to maintain health because of its high antioxidant activity from epigallocatechin gallate (EGCG). However, EGCG has a low ability to penetrate through the skin due to its hydrophilicity. The aim of this study is to improve the penetration of EGCG through the skin by lipid nanovesicle, namely ethosome. Methods: Ethosomes were made using thin layer hydration method. Ethosomes were formulated with different concentration, equal to 1% (F1), 1.5% (F2), and 2% (F3) of EGCG from green tea leaves extract. They were characterized, then a chosen formula would be formulated into a gel dosage form (ethosomal gel). A gel without ethosome (non-ethosomal gel) was prepared as a control. Both of them were evaluated their penetration enhancement ability using Franz diffusion cells with the abdomen skin of Sprague-Dawley rats. Results and Discussion: Based on the results, F1 had a spherical shape, Dv90 129.00 ± 0.00 nm, polydispersity index 0.05 ± 0.00, zeta potential at -62.6 ± 5.05 mV, and the highest entrapment efficiency of 54.39 ± 0.03 %.

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confidence: 99%

Novel Transdermal Ethosomal Gel Containing Green Tea (Camellia sinensis L. Kuntze) Leaves Extract: Formulation and In vitro Penetration Study

Ramadon¹,

Wirarti²,

Anwar³

2017

JYP

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“…The Tenoxicam entrapment capacity of ultradeformable vesicles was determined by centrifugation [8]. The entrapment efficiency was determined after separating the un-entrapped drug by centrifugation at 4 � C at 15,000 rpm (50,000 g) for 2 h, the vesicles were subjected to lyses using Triton-X 100 (0.1% v/v) and analysed for drug content.…”

Section: Entrapment Efficiencymentioning

confidence: 99%

Nano-appended transdermal gel of Tenoxicam via ultradeformable drug carrier system

Negi

Chauhan

Garg

2013

Journal of Experimental Nanoscience

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Tenoxicam is one of the potent non-steroidal anti-inflammatory drugs (NSAIDs), which is used clinically in the treatment of rheumatoid arthritis. Like other NSAIDs, Tenoxicam also suffers from the drawback of being associated with gastrointestinal side effects. Further, transdermal penetration of this drug is very poor, which circumvents the use of transdermal route. The main objective of this study is to exploit the concept of ultradeformable vesicles to increase the transport of Tenoxicam through transdermal route, and also to present it as a possible replacement for the oral NSAID therapy for rheumatoid arthritis. Three concentrations (5%, 15% and 25%) of three different surfactants (Tween-80, Span-80 and sodium desoxycholate) were used along with soya lecithin to prepare the ultradeformable vesicles. Among nine different types of vesicles, T3 vesicles (with 25% Tween-80) were found to have shown the smallest size (82.80 AE 0.74 nm), highest release in 24 h (98.01 AE 0.33%) and highest deformability (31.27 AE 0.28) and hence chosen for formulating into the gel. Among three different Carbopol Õ 934 concentrations (1%, 1.5% and 2%), G-2 with 1.5% carbopol was chosen as the final formulation. The formulation has shown almost twice the transdermal flux as compared to the gel with free Tenoxicam. The in vivo performance was also found to be significantly better than the oral Tenoxicam and marketed aceclofenac gel (Hifenac Õ ). This study concluded that the gel containing Tenoxicam encapsulated in ultradeformable vesicles has a better prospective for the transdermal use to treat rheumatoid arthritis.

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“…It can be seen that ethosome size exhibits a limited dependence on phospholipid concentration. An eight-fold increase in phospholipid concentration (from 0.5% to 4%) resulted in a twofold increase in ethosome size (from 118 ± 2 to 249 ± 24 nm; Touitou et al, 2000;Bendas & Tadros, 2007).…”

Section: Vesicle Size and Size Distributionmentioning

confidence: 99%

Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents

Pandey¹,

Golhani²,

Shukla³

2014

Drug Delivery

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Delivery across skin is attractive due to its easy accessibility. However, drug delivery across skin is still a challenge in biomedical sciences. Over the past few decades, various successful novel devices and techniques have emerged to optimize drug delivery across skin whose obstructing behavior constricts entry of most of the therapeutic agents. Inability of various conventional vesicular formulations, e.g. liposomes to pass through the tapered (430 nm) intercellular channels of stratum corneum, rendered invention of some lipid based vesicular carrier systems such as ethosomes which consist of phospholipid, ethanol and water. Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and/or the systemic circulation. In spite of their sophistication in conceptuality, they are exemplified by easiness in their preparation, safety and efficacy -a combination that can highly inflate their application. This review attempts to describe all aspects of ethosomes including roles and upshots of different excipients, various methods of preparation and characterizations, research reports on various drug deliveries, patent reports and future prospects.

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Enhanced transdermal delivery of salbutamol sulfate via ethosomes

Cited by 127 publications

References 32 publications

Novel Transdermal Ethosomal Gel Containing Green Tea (Camellia sinensis L. Kuntze) Leaves Extract: Formulation and In vitro Penetration Study

Novel Transdermal Ethosomal Gel Containing Green Tea (Camellia sinensis L. Kuntze) Leaves Extract: Formulation and In vitro Penetration Study

Nano-appended transdermal gel of Tenoxicam via ultradeformable drug carrier system

Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents

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