Enhanced tumor targetability of PEGylated mesoporous silica nanoparticles on in vivo optical imaging according to their size

Kim, Hye Lan; Lee, Sang Bong; Jeong, Hyeon Jin; Kim, Dong Wook

doi:10.1039/c4ra03905j

Cited by 25 publications

(13 citation statements)

References 31 publications

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“…Hobbs et al demonstrated that particle permeability for orthotopic brain tumors was limited to particles with a diameter ranging from 7 to 100 nm (33); however, differences within the size range were not described. Kim et al reported that PEGylated silica nanoparticle uptake in a U87MG mouse xenograft was greater with 100–150 nm particles as compared with larger and smaller particles (40 and > 300 nm) (38). However, in this study the tumor was implanted in the mouse shoulder, which may differ in the pore cutoff size as compared with the orthotopic brain tumor.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled 20-nm 64Cu-micelles enhance accumulation in rat glioblastoma

Seo

Ang

Mahakian

et al. 2015

Journal of Controlled Release

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There is an urgent need to develop nanocarriers for the treatment of glioblastoma multiforme (GBM). Using co-registered positron emission tomography (PET) and magnetic resonance (MR) images, here we performed systematic studies to investigate how a nanocarrier’s size affects the pharmacokinetics and biodistribution in rodents with a GBM xenograft. In particular, highly stable, long-circulating three-helix micelles (3HM), based on a coiled-coil protein tertiary structure, were evaluated as an alternative to larger nanocarriers. While the circulation half-life of the 3HM was similar to 110-nm PEGylated liposomes (t1/2 = 15.5 and 16.5 h, respectively), the 20-nm micelles greatly enhanced accumulation within a U87MG xenograft in nu/nu rats after intravenous injection. After accounting for tumor blood volume, the extravasated nanoparticles were quantified from the PET images, yielding ~0.77 %ID/cc for the micelles and 0.45 %ID/cc for the liposomes. For GBM lesions with a volume greater than 100 mm3, 3HM accumulation was enhanced both within the detectable tumor and in the surrounding brain parenchyma. Further, the nanoparticle accumulation was shown to extend to the margins of the GBM xenograft. In summary, 3HM provides an attractive nanovehicle for carrying treatment to GBM.

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Section: Introductionmentioning

confidence: 99%

Self-assembled 20-nm 64Cu-micelles enhance accumulation in rat glioblastoma

Seo

Ang

Mahakian

et al. 2015

Journal of Controlled Release

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“…They found that the 100–150 nm-sized particles had an 4–6.5 fold higher tumour uptake than the ones with diameter < 30 or >300 nm. 97 Decuzzi et al also studied the MDA-MB-231 breast tumour uptake of spherical silica beads with sizes ranging from 700 nm to 3 μm. 94 They found that the number of beads accumulated in the tumour site increased monotonically as the diameter decreased from 3 μm to 700 nm.…”

Section: Tumour Vascular Abnormalitiesmentioning

confidence: 99%

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

et al. 2017

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Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared with normal tissue, the tumour microenvironment has some unique properties, such as vascular abnormalities, hypoxia and acidic pH. There are many types of cells including tumour cells, macrophages, immune and fibroblasts cells, fed by defective blood vessels in the solid tumour. Exploiting the tumour microenvironment can benefit the design of nanoparticles for enhanced therapeutic effectiveness. In this review article, we summarized the recent progress in various nanoformulations for cancer therapy, with special emphasis on tumour microenvironment stimuli-responsive ones. Numerous tumour microenvironment modulation strategies with promising cancer therapeutic efficacy have also been highlighted. Future challenges and opportunities of design consideration are also discussed in details. We believe that these tumour microenvironment modulation strategies offer a good chance for the practical translation of nanoparticle formulas into clinic.

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“…High stability due to the charged surface, easy accomplishment of modification of the surface via siloxane-based cross linkers, and reactants-permeable mesoporous silica structures all make silica based nanoshells for use as biosensors, biomarkers, and other biomedical detectors. For instance, fluorophore-conjugated silica NPs had long been used as optical imaging agents with excellent 76,77 photostability and high fluorescence emission intensity.…”

Section: Biomedical Applications Of Npsmentioning

confidence: 99%

“…To date, silica NPs doped with fluorescent dyes, fluorescent NPs, or QDs were extensively studied as optical imaging probes for various biological [77][78][79][80][81][82] applications such as targeted cancer imaging in vitro and in vivo. For more reading about biomedical applications of silica NPs, please refer 83,84 to several excellent reviews .…”

Section: Biomedical Applications Of Npsmentioning

confidence: 99%

Nanoparticles in Biomedicine-Focus on Imaging Applications

Zhou¹,

Wang²,

Du³

et al. 2018

Eng. Sci.

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Over the last two decades, nanotechnology has become one of the most dynamically evolving field of research. Various types of nanoparticles are widely exploited to extend our understanding of biological interactions at the molecular level. They are actively engaged in the biomedical research for imaging, biosensing, drug delivery and/or concurrent therapy. Recent progress on this field is briefly reviewed here with an emphasis placed on the wide imaging applications of nanoparticles. Collectively, this field will no doubt make greater impact after we gradually address any potential risks of nanoparticles.

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Enhanced tumor targetability of PEGylated mesoporous silica nanoparticles on in vivo optical imaging according to their size

Abstract: The 100–150 nm-sized MSNs showed higher uptake at the tumor site in a particle size-dependent in vivo optical imaging study.

Cited by 25 publications

References 31 publications

Self-assembled 20-nm 64Cu-micelles enhance accumulation in rat glioblastoma

Self-assembled 20-nm 64Cu-micelles enhance accumulation in rat glioblastoma

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

Nanoparticles in Biomedicine-Focus on Imaging Applications

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