Enhanced tumor targeting effects of a novel paclitaxel-loaded polymer: PEG–PCCL-modified magnetic iron oxide nanoparticles

Li, Xinyi; Yang, Yuan; Jia, Yiping; Xuan, Ping; Yang, Ting; Wang, Yicheng; Ma, Xin; Chen, Qi; Sun, Min; Wei, Dapeng; Yu, Kuang; Yang, Li; Liu, Yu

doi:10.1080/10717544.2017.1373167

Cited by 23 publications

(11 citation statements)

References 24 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Current investigations have also synthesized IONPs employing different shells with anticancer agents conventionally administered, such as β-cyclodextrin [ 135 ], carmustine [ 136 ], cetuximab [ 137 , 138 , 139 ], cytarabine [ 140 ], daunomycin [ 141 ], docetaxel [ 142 , 143 ], epirubicin [ 144 ], 5-fluorouracil [ 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 ], gemcitabine [ 22 , 154 , 155 , 156 , 157 , 158 ], methotrexate [ 159 , 160 , 161 ], mitoxantrone [ 162 , 163 , 164 , 165 ] and paclitaxel [ 27 , 104 , 166 , 167 , 168 , 169 , 170 , 171 , 172 ]. It is noteworthy, however, that these nanosystems demonstrate magnetic properties only in the presence of external magnetic fields to prevent agglomerations of nanoparticles [ 111 ] and to allow a satisfactory performance in the target sites.…”

Section: Drugs Bound To Ionpsmentioning

confidence: 99%

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

et al. 2018

View full text Add to dashboard Cite

Medical applications and biotechnological advances, including magnetic resonance imaging, cell separation and detection, tissue repair, magnetic hyperthermia and drug delivery, have strongly benefited from employing iron oxide nanoparticles (IONPs) due to their remarkable properties, such as superparamagnetism, size and possibility of receiving a biocompatible coating. Ongoing research efforts focus on reducing drug concentration, toxicity, and other side effects, while increasing efficacy of IONPs-based treatments. This review highlights the methods of synthesis and presents the most recent reports in the literature regarding advances in drug delivery using IONPs-based systems, as well as their antimicrobial activity against different microorganisms. Furthermore, the toxicity of IONPs alone and constituting nanosystems is also addressed.

show abstract

Section: Drugs Bound To Ionpsmentioning

confidence: 99%

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

et al. 2018

View full text Add to dashboard Cite

show abstract

“…En el caso de la terapia de hipotermia del cáncer, las nanopartículas con altos niveles de magnetismo han mostrado un excelente comportamiento en la producción de calor en las regiones del tejido canceroso y pueden localizarse en la zona del tumor mediante la manipulación de un campo magnético. Luego, las nanopartículas son calentadas aplicando un campo magnético alterno y el calor concentrado en el sitio canceroso causa la muerte de las células cancerosas y puede ser considerado como un método eficiente en tratamiento de tumores [28], [29]. Asimismo, se demostró que nanopartículas de óxido de hierro inhiben el crecimiento de células de cáncer de pulmón de células pequeñas (CPCP) previniendo la formación de metástasis hepáticas [30].…”

Section: Nanopartículas En Aplicaciones Médicasunclassified

Aplicaciones Tecnológicas De Las Nanopartículas en La Medicina E Industria

Hurtado

Cortez-Valadez²,

Flores-Acosta³

2022

Epistemus

View full text Add to dashboard Cite

Los avances tecnológicos en la ciencia de los materiales han impactado en diferentes áreas del conocimiento como la medicina, los alimentos, los cosméticos, dispositivos electrónicos, entre otros, con el propósito de aprovechar las propiedades de las nanopartículas y resolver problemáticas actuales en beneficio de la sociedad. En esta revisión se presenta una descripción general y actualizada de las aplicaciones de las nanopartículas en diferentes áreas del conocimiento. Se muestra la importancia de los avances nanotecnológicos actuales para combatir diferentes bacterias patógenas, el virus SARS-CoV-2 y tratamientos de enfermedades cancerígenas con nanopartículas. Por otra parte, se discute brevemente la importancia de las nanopartículas en la industria textil, automotriz y agroindustria como alternativa para obtener telas inteligentes, mejoramiento de estética en carros, durabilidad de partes y disminución de contaminantes por CO2, así como en la producción de alimentos seguros, de alta calidad y sostenibles.

show abstract

“…Based on their results, PEG-PCCL-MMNP is a potential biocompatible candidate for tumor-specific targeting drug vehicles for hydrophobic drugs. 161 Chatzipavlidis et al produced magnetic pH-sensitive microcontainers. Figure 11 presents the preparation process of the Fe 3 O 4 poly(N,N0-methylenebis(acrylamide)comathacrylic acid) (P(MBAAm-co-MAA)) microcontainers and the chemical structure of Dau by a four-step process: 1) the fabrication of citrate-modified MNPs using the coprecipitation technique, 2) encapsulation of MNPs in noncrosslinked poly(methacrylic acid) (PMAA) microspheres leads to a core/shell structure, 3) synthesis of a P(MBAAm-co-MAA) layer on the magnetic PMAA microsphere surface in order to synthesize a trilayer hybrid microsphere, and 4) the removal of the PMAA layer in ethanol and formation of a stable P(MBAAm-co-MAA) microcontainer with MNPs entrapped inside the formed cavity.…”

Section: Modification Of Io Nps For Ptx and Dau Deliverymentioning

confidence: 99%

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

Jahangirian¹,

Kalantari²,

Izadiyan³

et al. 2019

IJN

178

106

View full text Add to dashboard Cite

Conventional cancer treatment techniques show several limitations including low or no specificity and consequently a low efficacy in discriminating between cancer cells and healthy cells. Recent nanotechnology developments have introduced smart and novel therapeutic nanomaterials that take advantage of various targeting approaches. The use of nanotechnology in medicine and, more specifically, drug delivery is set to spread even more rapidly than it has over the past two decades. Currently, many nanoparticles (NPs) are under investigation for drug delivery including those for cancer therapy. Targeted nanomaterials bind selectively to cancer cells and greatly affect them with only a minor effect on healthy cells. Gold nanoparticles (Au-NPs), specifically, have been identified as significant candidates for new cancer therapeutic modalities because of their biocompatibility, easy functionalization and fabrication, optical tunable characteristics, and chemophysical stability. In the last decade, there has been significant research on Au-NPs and their biomedical applications. Functionalized Au-NPs represent highly attractive and promising candidates for drug delivery, owing to their unique dimensions, tunable surface functionalities, and controllable drug release. Further, iron oxide NPs due to their "superparamagnetic" properties have been studied and have demonstrated successful employment in numerous applications. In targeted drug delivery systems, drug-loaded iron oxide NPs can accumulate at the tumor site with the aid of an external magnetic field. This can lead to incremental effectiveness in drug release to the tumor site and vanquish cancer cells without harming healthy cells. In order for the application of iron oxide NPs in the human body to be realized, they should be biodegradable and biocompatible to minimize toxicity. This review illustrates recent advances in the field drug and small molecule delivery such as fluorouracil, folic acid, doxorubicin, paclitaxel, and daunorubicin, specifically when using gold and iron oxide NPs as carriers of anticancer therapeutic agents.

show abstract

Enhanced tumor targeting effects of a novel paclitaxel-loaded polymer: PEG–PCCL-modified magnetic iron oxide nanoparticles

Abstract: PEG-PCCL-MNP is a potential candidate of biocompatible and tumor-specific targeting drug vehicle for hydrophobic drugs.

Cited by 23 publications

References 24 publications

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

Aplicaciones Tecnológicas De Las Nanopartículas en La Medicina E Industria

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

Contact Info

Product

Resources

About