2019
DOI: 10.2174/2211738507666190122121242
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Enhanced Water Dispersibility of Curcumin Encapsulated in Alginate-Polysorbate 80 Nano Particles and Bioavailability in Healthy Human Volunteers

Abstract: Background: The turmeric (Curcuma longa) plant, a perennial herb of the ginger family, is an agronomic crop in the south and southeast tropical Asia. Turmeric an Indian yellow gold and universal spice is described in Ayurveda, an ancient treatise on longevity and quality life for the treatment of various inflammatory disorders. The oral bioavailability of curcumin is low due to poor aqueous solubility, alkaline instability and speedy elimination. Objective: The present study is designed to prepare alginate p… Show more

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Cited by 42 publications
(30 citation statements)
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“…The % EE increases with an increase of SA in the polymer matrix this is due to curcumin alginate interactions (Hydrophilic and Hydrophobic). A similar observation was observed by Govindaraju et al [38] from their curcumin encapsulated in alginate-polysorbate 80 nanoparticles. The % EE increases with the increase of KA content in the polymer matrix, which is due to the availability of large basal space, good absorption capacity and availability of free-OH groups of KA.…”
Section: Encapsulation Efficiency (% Ee)supporting
confidence: 79%
“…The % EE increases with an increase of SA in the polymer matrix this is due to curcumin alginate interactions (Hydrophilic and Hydrophobic). A similar observation was observed by Govindaraju et al [38] from their curcumin encapsulated in alginate-polysorbate 80 nanoparticles. The % EE increases with the increase of KA content in the polymer matrix, which is due to the availability of large basal space, good absorption capacity and availability of free-OH groups of KA.…”
Section: Encapsulation Efficiency (% Ee)supporting
confidence: 79%
“…On the other hand, the low stability and bioavailability of curcumin limit its clinical application (16). Therefore, several curcumin nano-structures have been developed that overcome these drawbacks (17,27). Dendrosomal nano-curcumin (DNC) is one of those nano-structures that improve the solubility, cellular uptake, and toxicity of curcumin (11,18).…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, the nanoparticle size was reducible by decreasing the concentration of alginate [ 133 ]. Another study by Govindaraju et al, indicated the role of alginate on curcumin loaded alginate nanoparticles synthesized by ionotropic gelation method [ 147 ]. They have reported that high alginate concentration was associated with a significantly increased zeta potential from +150 ± 1.15 mV to +200 ± 2.15 mV and a slightly changed size and encapsulation efficiency of the prepared nanoparticle.…”
Section: Factors Influencing Alginate Nanoparticles’ Characteristimentioning
confidence: 99%
“…They have reported that high Poloxamer 407 concentration was associated with decreased both size and polydispersity index of the prepared nanoparticles [ 149 ]. Moreover, incorporation of Polysorbate 80 (10% v / v , 20% v / v , and 40% v / v ) has rendered a rise in particle size, while the encapsulation efficiency peaked at medium concentration of the surfactant [ 147 ]. Similar results were also reported by Scolari et al, in which rifampicin-ascorbic acid-loaded alginate nanoparticles coated with chitosan were fabricated by ionic gelation/complexation method.…”
Section: Factors Influencing Alginate Nanoparticles’ Characteristimentioning
confidence: 99%