Enhanced wound healing effect of <i>Areca catechu</i> L. ointment via antibacterial activity and anti-inflammatory process at grade IIA burns in rats

Sandhiutami, Ni Made Dwi; Fahleni, Fahleni; Miftahurrohmah, Nur; Widhiyasari, Ni Kadek Ari; Azalia, Afifah; Amalia, Indah

doi:10.34172/jhp.2023.42

Cited by 6 publications

(1 citation statement)

References 27 publications

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“…This anti-inflammatory activity is a very complex phenomenon that is supported by antioxidant activities strongly correlated with the contents of phenolic compounds, especially their flavonoids [39]. The involved second mechanism is the antimicrobial activity of phenolic compounds, which limits the proliferation of microorganisms that prevent successful healing [40]. The flavonoids in turn contribute differently because they improve capillary formation, which supplies wounds with the materials necessary for the structuring of tissues [41].…”

Section: Discussionmentioning

confidence: 99%

Effect of Phenolic Compounds Extracted from Turmeric (Curcuma longa L.) and Ginger (Zingiber officinale) on Cutaneous Wound Healing in Wistar Rats

Bouchama,

Zinedine,

Rocha

et al. 2023

Cosmetics

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Turmeric and ginger, widely used rhizomes in culinary arts, have several beneficial biological activities, such as hypoglycemic, hepato-protective, antimicrobial, and antioxidant properties. This work investigated the effects of three phenolic extracts isolated from turmeric and ginger rhizomes on anti-inflammatory and healing properties using the solid–liquid extraction method. Wistar rats were used as a biological model. The anti-inflammatory activity was evaluated on induced edema in the rat’s hind paw using carrageenan (1%). Paw volume was measured at 0 min, 45 min, 3 h, and 5 h. Treatment with turmeric and ginger extracts, administered at a dose of 100 mg/kg, revealed a reduction in edema volume by 98.8%, 94.8%, and 98.3% using an aqueous extract of turmeric, ethanolic extract of turmeric, and methanolic extract of ginger, respectively. The healing activity parameters of induced burns on the rat’s dorsal region in nine groups (7 rats each) were monitored daily throughout the experiment’s duration. Results showed that the application of creams composed of petroleum jelly dispersing turmeric and ginger extracts to wounds at a dose of 100 mg/kg g induced complete healing after 19 days while the negative control was only 60% cured. On day 14, the aqueous, ethanolic, and methanolic turmeric extracts nearly resulted in complete tissue repair by 95.26%, 98.34%, and 87.39%, respectively. According to the chromatographic analysis (Sephadex G50 column), there is a variation in the molecular weight distribution of phenolic compounds (polymers, oligomers, and monomers) in the three studied extracts, which has a differential effect on the anti-inflammatory and wound healing activities of the extracts.

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Section: Discussionmentioning

confidence: 99%