Enhanced x-ray irradiation-induced cancer cell damage by gold nanoparticles treated by a new synthesis method of polyethylene glycol modification

Liu, Chi-Jen; Wang, Changhai; Chien, Chia‐Chi; Yang, Tsung-Yeh; Chen, Shin‐Tai; Leng, Wei-Hua; Lee, Cheng-Feng; Lee, Kuen-Ho; Hwu, Y.; Lee, Yao-Chang; Cheng, Chia‐Liang; Yang, Chung‐Shi; Chen, Y J; Je, Jung Ho; Margaritondo, G.

doi:10.1088/0957-4484/19/29/295104

Cited by 107 publications

(85 citation statements)

References 21 publications

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“…Thus, these AuNPs, ranging from 10 to 40 nm, do not appear to influence cell radiation sensitivity, at least under our experimental conditions. Our results are in contrast with previous reports showing that certain AuNPs coated with PEG or amino acids could enhance radiation-induced cytotoxicity in mice colorectal adenocarcinoma and breast cancer cells [9,10]. While the reason for this discrepancy is currently unknown, it raises an interesting possibility that different coatings of the AuNPs used in these studies may be responsible for the different outcomes observed.…”

contrasting

confidence: 99%

“…However, the property of intracellular nanoparticles and their effect on cellular processes under more complex scenarios such as when cells are treated with ionizing radiation (IR) remain largely unclear. Recently, it was reported that certain gold nanoparticles (coated with polyethylene glycol (PEG) and amino acids) could enhance radiationinduced cytotoxicity in mice colorectal adenocarcinoma and breast cancer cells [9,10]. However, there has been a lack of systematic analyses on how different nanomaterials generally affect cellular radiation sensitivity, as well as the respective contributions by nanoparticles and their coatings.…”

mentioning

confidence: 99%

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Ag nanoparticles sensitize IR-induced killing of cancer cells

Sun

et al. 2009

Cell Res

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contrasting

confidence: 99%

mentioning

confidence: 99%

Ag nanoparticles sensitize IR-induced killing of cancer cells

Sun

et al. 2009

Cell Res

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“…[3][4][5][6][7][8][9] Recently, gold nanoparticles have been suggested as a novel radiosensitizer technique in radiotherapy, because their strong photoelectric absorption and secondary electron caused by gamma or X-ray irradiation can accelerate DNA strand breakage. [10][11][12] Therefore, it was necessary to investigate the toxicity of these materials.…”

Section: Introductionmentioning

confidence: 99%

Size-dependent in vivo toxicity of PEG-coated gold nanoparticles

Zhang¹,

Wu²,

Shen³

et al. 2011

IJN

392

246

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Background: Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of 5, 10, 30, and 60 nm PEG-coated gold nanoparticles in mice. Methods: Animal survival, weight, hematology, morphology, organ index, and biochemistry were characterized at a concentration of 4000 µg/kg over 28 days. Results:The PEG-coated gold particles did not cause an obvious decrease in body weight or appreciable toxicity even after their breakdown in vivo. Biodistribution results show that 5 nm and 10 nm particles accumulated in the liver and that 30 nm particles accumulated in the spleen, while the 60 nm particles did not accumulate to an appreciable extent in either organ. Transmission electron microscopic observations showed that the 5, 10, 30, and 60 nm particles located in the blood and bone marrow cells, and that the 5 and 60 nm particles aggregated preferentially in the blood cells. The increase in spleen index and thymus index shows that the immune system can be affected by these small nanoparticles. The 10 nm gold particles induced an increase in white blood cells, while the 5 nm and 30 nm particles induced a decrease in white blood cells and red blood cells. The biochemistry results show that the 10 nm and 60 nm PEG-coated gold nanoparticles caused a significant increase in alanine transaminase and aspartate transaminase levels, indicating slight damage to the liver. Conclusion: The toxicity of PEG-coated gold particles is complex, and it cannot be concluded that the smaller particles have greater toxicity. The toxicity of the 10 nm and 60 nm particles was obviously higher than that of the 5 nm and 30 nm particles. The metabolism of these particles and protection of the liver will be more important issues for medical applications of gold-based nanomaterials in future.

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“…Further, Liu has shown that gold nanoparticles modified with polyethylene glycol can induce toxicity in CT26 tumor cells exposed to irradiation. 19 The novel properties of nanomaterials need to be explored in order to improve traditional oncology management technologies and to develop high-profile treatments with low overall toxicity to the organism and high efficacy in targeting and destroying cancer stem cells. In the present study, we aimed to synthesize a drug delivery vector, by physically coupling an anticancer drug, temozolomide, to the surface of gold nanostructures treated with L-aspartate (GNP-Laspartate-TMZ) and to test their ability to kill malignant glioma-derived cancer stem cells.…”

Section: Introductionmentioning

confidence: 99%

Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles

Orza

Şoriţău²,

Tomuleasa³

et al. 2013

IJN

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Abstract:The low rate of survival for patients diagnosed with glioblastoma may be attributed to the existence of a subpopulation of cancer stem cells. These stem cells have certain properties that enable them to resist chemotherapeutic agents and ionizing radiation. Herein, we show that temozolomide-loaded gold nanostructures are efficient in reducing chemoresistance and destroy 82.7% of cancer stem cells compared with a 42% destruction rate using temozolomide alone. Measurements of in vitro cytotoxicity and apoptosis indicate that combination with gold facilitated the ability of temozolomide, an alkylating drug, to alter the resistance of these cancer stem cells, suggesting a new chemotherapy strategy for patients diagnosed with inoperable recurrent malignant glioma.

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Enhanced x-ray irradiation-induced cancer cell damage by gold nanoparticles treated by a new synthesis method of polyethylene glycol modification

Cited by 107 publications

References 21 publications

Ag nanoparticles sensitize IR-induced killing of cancer cells

Ag nanoparticles sensitize IR-induced killing of cancer cells

Size-dependent in vivo toxicity of PEG-coated gold nanoparticles

Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles

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