Enhancement and Regulation of Peptide Crystallization with the Application of Taylor Vortex: A Case Study of Vancomycin

Li, Beibei; Yao, Tuo; Tao, Tiantian; Han, Dandan; Yang, Huaiyu; Gao, Zhenguo; Gong, Junbo

doi:10.1021/acs.iecr.3c02833

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Moreover, numerous studies have indicated that agitation is a critical factor in controlling the nucleation of polymorphic crystals and phase transformation as it significantly impacts the kinetics of the process. − In our previous study, stable nucleation was initiated in the rotating disk (RD) crystallizer to produce CAF/maleic acid (1:1) cocrystals. This was achieved by utilizing Batchelor vortex flow to enhance viscous frictional dissipation and molecular alignment.…”

Section: Introductionmentioning

confidence: 99%

Stoichiometric Diversity of Caffeine and 4-Hydroxybenzoic Acid Cocrystals in Batchelor Vortex Flow

Li,

Kim

2024

Crystal Growth & Design

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In this study, we explored the influence of fluid flow on the stoichiometric diversity in cocrystal formation. The cocrystallization of caffeine (CAF) with 4-hydroxybenzoic acid (4-HBA) was carried out using rotating disk (RD) and mixing tank (MT) crystallizers, which generated distinct flow regimes: Batchelor vortex and turbulent eddy flows, respectively. The outcomes revealed the formation of hitherto unknown (1:3) cocrystals, alongside the known (2:1) and (1:2) cocrystals. Notably, the fluid motion was found to significantly affect the nucleation of cocrystals with stoichiometric diversity, with stable (1:3) cocrystal nucleation being more effective in the Batchelor vortex flow due to improved molecular alignment. The phase transformation of cocrystals was also subject to the influence of fluid dynamics. In the Batchelor vortex flow, (2:1) and (1:2) cocrystals transitioned directly to (1:3) cocrystals, whereas in the turbulent eddy flow, (2:1) first converted to (1:2) cocrystals before reaching the (1:3) cocrystals. Kinetic factors related to nucleation and phase transformation led to the temporary formation of either metastable (2:1) and (1:2) cocrystals or stable (1:3) cocrystals, depending on the fluid motion pattern. However, aligning with thermodynamic principles, only the stable (1:3) cocrystal was the ultimate product at the end of the process. This research underscores the significance of fluid flow patterns in controlling the stoichiometry of cocrystals, with important implications for pharmaceutical development and material science applications.

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Section: Introductionmentioning

confidence: 99%

Stoichiometric Diversity of Caffeine and 4-Hydroxybenzoic Acid Cocrystals in Batchelor Vortex Flow

Li,

Kim

2024

Crystal Growth & Design

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Prevention of Crystal Agglomeration: Mechanisms, Factors, and Impact of Additives

Zhang,

Du,

Wang

et al. 2024

Crystals

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Crystal agglomeration is a common phenomenon for most chemicals and pharmaceuticals. The formation of agglomerates usually lowers product purity and generates a broad particle size distribution. This review focuses on preventing agglomeration in solution crystallization, the storage of crystals, and pharmaceutical preparation processes. The agglomeration mechanisms in these stages are analyzed and the effects of operating parameters are summarized. Furthermore, effective control means related to the crystallization environment are elaborated, including solvents, ultrasound, and additives. Special attention is paid to the influence of additives in preventing the aggregation of both suspensions and dried powders. Besides additives used in solution crystallization, the roles of anti-caking agents, stabilizers of nanosuspensions, and excipients of solid dispersions are also discussed. The additive type and properties like hydrophilicity, hydrophobicity, ionic strength, viscosity, the steric hindrance effect, and intermolecular interactions between additives and crystals can greatly affect the degree of agglomeration.

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Enhancement and Regulation of Peptide Crystallization with the Application of Taylor Vortex: A Case Study of Vancomycin

Cited by 2 publications

References 33 publications

Stoichiometric Diversity of Caffeine and 4-Hydroxybenzoic Acid Cocrystals in Batchelor Vortex Flow

Stoichiometric Diversity of Caffeine and 4-Hydroxybenzoic Acid Cocrystals in Batchelor Vortex Flow

Prevention of Crystal Agglomeration: Mechanisms, Factors, and Impact of Additives

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