Enhancement by interferon of natural cytotoxic activities of lymphocytes from human cord blood and peripheral blood of aged persons

Resistance to Interferon of a Human Adenocarcinoma Cell Line, HEC-1, and its Sensitivity to Natural Killer Cell Action

“…The specific activity was 4 × 106 reference units/mg protein. Fibroblast interferon (HulFN-fl) was a gift from Dr A. BiUiau and was the same preparation as used previously (Sato et al, 1979).…”

Inhibitory effect of cholera toxin on human natural cell‐mediated cytotoxicity and its augmentation by interferon

“…Enhanced natural cytotoxic activities in the presence of interferon in the target-lymphocyte mixed culture using the same target cells have already been reported (Sato et al, 1979). In order to obtain minimal dosage for maximal enhancing activity of interferon, lymphocytes were treated with interferon at various concentrations.…”

Protection against Epstein-Barr Virus Oncogenesis

“…Interferon alone, however, was not cytotoxic enough, even though a much larger dose was given. Since the mixture of lymphocytes and interferon was not significantly effective, the high frequency of cytotoxicity in this study does not seem to be related to the enhancement of natural killer (NK) cell activity as generally known (Einhorn et at., 1978;Trinchieri and Santoli, 1978;Skurkovich et at., 1978;Sato et at., 1979;Zarling et at., 1979;Herberman et at., 1979;Droller et at., 1979;Saksela et at., 1979;Moore and Potter, 1980). A similar type of enhancement of ADCC by interferon was also suggested recently in a different experimental system other than EBV (Herberman et at., 1979;Droller et at., 1979).…”