Enhancement in corneal permeability of riboflavin using cyclodextrin derivates complexes as a previous step to transepithelial cross-linking

Penedo, Andrea Conde; Tomé, Victoria Díaz; Ferreiro, Anxo Fernández; Barcia, Miguel González; Otero-Espinar, Francisco J.

doi:10.1016/j.ejpb.2021.02.012

Cited by 15 publications

(7 citation statements)

References 54 publications

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“…The chart of DC ( Figure 4 b) shows that oil proportion significantly influenced DC. It has been confirmed that retention of a drug depended on the distribution gradient of the drug between the vehicle of the NE and the eye tissues [ 54 , 55 ]. Thus, the composition of an NE that exhibits low DS and high DC was considered to be an ideal formulation.…”

Section: Resultsmentioning

confidence: 99%

Development of a Luliconazole Nanoemulsion as a Prospective Ophthalmic Delivery System for the Treatment of Fungal Keratitis: In Vitro and In Vivo Evaluation

et al. 2022

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Luliconazole (LCZ), a novel imidazole drug, has broad-spectrum and potential antifungal effects, which makes it a possible cure for fungal keratitis; nevertheless, its medical use in ocular infections is hindered by its poor solubility. The purpose of this study was to design and optimize LCZ nanoemulsion (LCZ-NE) formulations using the central composite design-response surface methodology, and to investigate its potential in improving bioavailability following ocular topical administration. The LCZ-NE formulation was composed of Capryol 90, ethoxylated hydrogenated castor oil, Transcutol® P and water. The shape of LCZ-NE was spherical and uniform, with a droplet size of 18.43 ± 0.05 nm and a low polydispersity index (0.070 ± 0.008). The results of an in vitro release of LCZ study demonstrated that the LCZ-NE released more drug than an LCZ suspension (LCZ-Susp). Increases in the inhibition zone indicated that the in vitro antifungal activity of the LCZ-NE was significantly improved. An ocular irritation evaluation in rabbits showed that the LCZ-NE had a good tolerance in rabbit eyes. Ocular pharmacokinetics analysis revealed improved bioavailability in whole eye tissues that were treated with LCZ-NE, compared with those treated with LCZ-Susp. In conclusion, the optimized LCZ-NE formulation exhibited excellent physicochemical properties, good tolerance, enhanced antifungal activity and bioavailability in eyes. This formulation would be safe, and shows promise in effectively treating ocular fungal infections.

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Section: Resultsmentioning

confidence: 99%

Development of a Luliconazole Nanoemulsion as a Prospective Ophthalmic Delivery System for the Treatment of Fungal Keratitis: In Vitro and In Vivo Evaluation

et al. 2022

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“…There have been concerns as to the effectiveness of epithelium-on CXL as the epithelium acts as a barrier to diffusion of riboflavin. Methods including iontophoresis or ways to enhance the chemical permeability, for example, using benzalkonium chloride have been trialled to overcome the barriers to riboflavin diffusion with an intact epithelium [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Epithelium-on versus epithelium-off corneal collagen crosslinking for keratoconus: a systematic review and meta-analysis

Borchert,

Kandel,

Watson

2023

Graefes Arch Clin Exp Ophthalmol

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Purpose Corneal collagen crosslinking (CXL) is the primary treatment for progressive keratoconus which has a significant impact on vision and quality of life. Our study aimed to compare the efficacy and safety of epithelium-on versus epithelium-off CXL to treat keratoconus. Methods We searched PubMed, Medline, Embase, Web of Science, and Scopus databases. We included studies that compared standard epithelium-off with epithelium-on CXL. The primary outcome measures were changes in corrected distance visual acuity (CDVA) and maximum keratometry (Kmax), and the secondary outcomes were uncorrected distance visual acuity (UDVA), central corneal thickness (CCT), and adverse events. A meta-analysis was performed on the primary and secondary outcomes based on the weighted mean differences between baseline to 12-month follow-up. Results The search retrieved 887 publications with 27 included in the systematic review. A total of 1622 eyes (1399 patients; age 25.51 ± 4.02 years) were included in comparisons of epithelium-off to epithelium-on CXL in keratoconus. Epithelium-off CXL treated 800 eyes and epithelium-on CXL for 822 eyes. At 12-month follow-up, CDVA and Kmax showed no significant difference between the epithelium-off and epithelium-on CXL. The secondary outcomes showed that UDVA was better in epithelium-off CXL (− 0.11D, 95% CI − 0.12, − 0.1; p < 0.001) and there was more thinning in CCT in epithelium-off CXL (− 3.23 μm, 95% CI − 4.64, − 1.81; p <0.001). Conclusion Epithelium-off and epithelium-on CXL were both effective to treat progressive keratoconus. Further research is needed to compare the long-term outcomes and safety of both CXL protocols for adaptation into clinical practice.

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“…Transmittance measurements were taken from 200 to 800 nm. The lenses were placed on a solid holder between the lamp and the detector, with the concave surface of the lens aligned perpendicular to the light beam ( Conde Penedo et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Inkjet drug printing onto contact lenses: Deposition optimisation and non-destructive dose verification

Pollard

Seoane-Viaño

Ong

et al. 2023

International Journal of Pharmaceutics: X

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Enhancement in corneal permeability of riboflavin using cyclodextrin derivates complexes as a previous step to transepithelial cross-linking

Cited by 15 publications

References 54 publications

Development of a Luliconazole Nanoemulsion as a Prospective Ophthalmic Delivery System for the Treatment of Fungal Keratitis: In Vitro and In Vivo Evaluation

Development of a Luliconazole Nanoemulsion as a Prospective Ophthalmic Delivery System for the Treatment of Fungal Keratitis: In Vitro and In Vivo Evaluation

Epithelium-on versus epithelium-off corneal collagen crosslinking for keratoconus: a systematic review and meta-analysis

Inkjet drug printing onto contact lenses: Deposition optimisation and non-destructive dose verification

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