Enhancement in Ex Vivo Phagocytic Capacity of Peritoneal Leukocytes in Mice by Oral Delivery of Various Lactic-Acid-Producing Bacteria

Lee, Yeonhee; Lee, Taik-Soo

doi:10.1007/s00284-004-4377-5

Cited by 20 publications

(9 citation statements)

References 37 publications

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“…This is an essential activity of polymorphonuclear cells and monocytes-macrophages in innate immunity. Similar results have been reported using different labeled bacteria as well as Escherichia coli [55]. A previous study also documented a significant increase in phagocytosis after treatment with different strains of Lactobacillus both in vitro and in vivo [56][57][58].…”

Section: Discussionsupporting

confidence: 88%

Evaluation of Immunomodulatory Activities of the Heat-Killed Probiotic Strain Lactobacillus casei IMAU60214 on Macrophages In Vitro

et al. 2020

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Most Lactobacillus species have beneficial immunological (“immunoprobiotic”) effects in the host. However, it is unclear how probiotic bacteria regulate immune responses. The present study investigated the effects of heat-killed Lactobacillus casei IMAU60214 on the activity of human monocyte-derived macrophages (MDMs). Human MDMs were treated with heat-killed L. casei at a ratio (bacteria/MDM) of 50:1, 100:1, 250:1, and 500:1, and then evaluated for the following: NO production, by Griess reaction; phagocytosis of FITC-labeled Staphylococcus aureus particles; cytokine secretion profile (tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-12p70, IL-10, and transforming growth factor (TGF)-β) by ELISA; and costimulatory molecule (CD80 and CD86) surface expression, by flow cytometry. Heat-killed L. casei IMAU60214 enhanced phagocytosis, NO production, cytokine release, and surface expression of CD80 and CD86 in a dose-dependent manner. All products were previously suppressed by pretreatment with a Toll-like receptor 2 (TLR2)-neutralizing antibody. Overall, our findings suggest that this probiotic strain promotes an M1-like pro-inflammatory phenotype through the TLR2 signaling pathway. These effects on macrophage phenotype help explain the probiotic efficacy of Lactobacillus and provide important information for the selection of therapeutic targets and treatments compatible with the immunological characteristics of this probiotic strain.

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Section: Discussionsupporting

confidence: 88%

Evaluation of Immunomodulatory Activities of the Heat-Killed Probiotic Strain Lactobacillus casei IMAU60214 on Macrophages In Vitro

et al. 2020

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“…Administration to mice with two B . strains of lactobasilli isolated from healthy centenarians enhanced NK cell activity and phagocytic activity of macrophages (204), and coupled with probiotics L. fermentum strain PL9005 and L. plantarum strain PL9011 enhanced the phagocytic capacity of peritoneal leukocytes (205). Mice receiving L. paracasei NTU 101 (10 8 CFU/d) for 6 or 9 wk showed higher expression of DC maturation markers (MHC-II hi , CD80 + , and CD86 + ) and NK group-2D (NKG2D), as well as enhanced lymphocyte proliferation in response to L. paracasei Ag (206), which together suggest that probiotics may enhance specific immunity by promoting APC function.…”

Section: Modulation Of Immune Function By Nutrients and Food Componentsmentioning

confidence: 99%

Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance

et al. 2019

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It is well-established that the nutritional deficiency or inadequacy can impair immune functions. Growing evidence suggests that for certain nutrients increased intake above currently recommended levels may help optimize immune functions including improving defense function and thus resistance to infection, while maintaining tolerance. This review will examine the data representing the research on prominent intervention agents n-3 polyunsaturated fatty acids (PUFA), micronutrients (zinc, vitamins D and E), and functional foods including probiotics and tea components for their immunological effects, working mechanisms, and clinical relevance. Many of these nutritive and non-nutritive food components are related in their functions to maintain or improve immune function including inhibition of pro-inflammatory mediators, promotion of anti-inflammatory functions, modulation of cell-mediated immunity, alteration of antigen-presenting cell functions, and communication between the innate and adaptive immune systems. Both animal and human studies present promising findings suggesting a clinical benefit of vitamin D, n-3 PUFA, and green tea catechin EGCG in autoimmune and inflammatory disorders, and vitamin D, vitamin E, zinc, and probiotics in reduction of infection. However, many studies report divergent and discrepant results/conclusions due to various factors. Chief among them, and thus call for attention, includes more standardized trial designs, better characterized populations, greater consideration for the intervention doses used, and more meaningful outcome measurements chosen.

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“…achieve this beneficial effect by acting on the mucosal immune system, in particular DCs and NK cells (271). As an example, it has been shown that administration of lactobacilli to mice can enhance the immune function in mice by increasing NK cell activity and phagocytic activity of macrophages (272), as well as enhance the phagocytic capacity of peritoneal leukocytes (273), increase the expression of DC-maturation markers, and enhance lymphocyte proliferation (274). Consistent with studies using animal models, human studies also showed that probiotic use could have a positive effect on the immune system.…”

Section: Role Of Probiotics Diet and Fasting In Immune Function The mentioning

confidence: 99%

Importance of Dietary Changes During the Coronavirus Pandemic: How to Upgrade Your Immune Response

Châari

Bendriss

Zakaria

et al. 2020

Front. Public Health

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The new coronavirus pandemic continues to spread causing further public health, social, and economic issues. The disparities in the rates of death between countries poses questions about the importance of lifestyle habits and the immune status of populations. An exploration of dietary habits and COVID-19-related death might unravel associations between these two variables. Indeed, while both nutritional excess and deficiency are associated with immunodeficiency, adequate nutrition leading to an optimally functioning immune system may be associated with better outcomes with regards to preventing infection and complications of COVID-19, as well as developing a better immune response to other pathogenic viruses and microorganisms. This article outlines the key functions of the immune system and how macronutrients, micronutrients, and metabolites from the gut microbiome can be essential in the development of an efficient immune system. In addition, the effects of intermittent fasting on the inflammatory state as well as metabolic parameters will be discussed.

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Enhancement in Ex Vivo Phagocytic Capacity of Peritoneal Leukocytes in Mice by Oral Delivery of Various Lactic-Acid-Producing Bacteria

Cited by 20 publications

References 37 publications

Evaluation of Immunomodulatory Activities of the Heat-Killed Probiotic Strain Lactobacillus casei IMAU60214 on Macrophages In Vitro

Evaluation of Immunomodulatory Activities of the Heat-Killed Probiotic Strain Lactobacillus casei IMAU60214 on Macrophages In Vitro

Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance

Importance of Dietary Changes During the Coronavirus Pandemic: How to Upgrade Your Immune Response

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