Enhancement of alendronate encapsulation in chitosan nanoparticles

Miladi, Karim; Sfar, Souad; Fessi, Hatem; Elaı̈ssari, Abdelhamid

doi:10.1016/j.jddst.2015.04.007

Cited by 60 publications

(37 citation statements)

References 29 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The initial burst release from the chitosan nanoparticles is either because of swelling of the polymer, creating pores, or diffusion of the drug from the surface of the polymer [27]. Chitosan nanoparticles also exhibit a pH-dependent drug release because of the solubility of chitosan [28]. Chitosan derivatives alter the release of drug from the NP, affording tunable drug release [29] and impacting the pharmacokinetic profile of the loaded drug.…”

Section: Drug Release From Chitosan Nanoparticlesmentioning

confidence: 99%

“…High NP encapsulation efficiency of alendronate sodium was achieved by formulating chitosan nanoparticles via an ion gelation technique. Drug release was clearly pH-dependent; in 0.1N HCl, almost 80% of the drug was released within 60 min while in PBS (pH 6.8) a maximum of 40% of the drug was released over 4 h, suggesting that factors other than chitosan’s pH solubility profile influenced drug release in this case and that optimization is multifactorial [28]. This highlights the importance of examining the degree of surface coverage of the nanoparticles with chitosan and of performing ongoing dissolution studies in biorelevant media during formulation development.…”

Section: Chitosan In Oral Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

et al. 2017

View full text Add to dashboard Cite

The focus of this review is to provide an overview of the chitosan based nanoparticles for various non-parenteral applications and also to put a spotlight on current research including sustained release and mucoadhesive chitosan dosage forms. Chitosan is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound dressing applications. Chitosan has been used as a carrier in polymeric nanoparticles for drug delivery through various routes of administration. Chitosan has chemical functional groups that can be modified to achieve specific goals, making it a polymer with a tremendous range of potential applications. Nanoparticles (NP) prepared with chitosan and chitosan derivatives typically possess a positive surface charge and mucoadhesive properties such that can adhere to mucus membranes and release the drug payload in a sustained release manner. Chitosan-based NP have various applications in non-parenteral drug delivery for the treatment of cancer, gastrointestinal diseases, pulmonary diseases, drug delivery to the brain and ocular infections which will be exemplified in this review. Chitosan shows low toxicity both in vitro and some in vivo models. This review explores recent research on chitosan based NP for non-parenteral drug delivery, chitosan properties, modification, toxicity, pharmacokinetics and preclinical studies.

show abstract

Section: Drug Release From Chitosan Nanoparticlesmentioning

confidence: 99%

Section: Chitosan In Oral Drug Deliverymentioning

confidence: 99%

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Furthermore, the pH dependent solubility of chitosan enables tuneable pH-dependent release [9], which can be further tailored by derivatisation [10] or cross-linking (with TPP for example)…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the mucoadhesive properties of chitosan nanoparticles prepared using different chitosan to tripolyphosphate (CS:TPP) ratios

Hejjaji

Smith

Morris

2018

International Journal of Biological Macromolecules

104

View full text Add to dashboard Cite

 the interactions between CS:TPP nanoparticles and mucin were evaluated  the degree of interaction depends on the CS:TPP ratio, -potential and viscosity  a CS:TPP ratio of 4:1 displayed the strongest interaction with mucin  greater mucin binding efficiencies achieved at CS:TPP ratios of 4:1 and higher  a minimum CS:TPP ratio of 4:1 is required for stable interactions with mucin 3

show abstract

“…Several drugs and polyphenolsencapsulated inside chitosan moieties were synthesized such as catechin and epigallocatechin [16], tamoxifen [17], alendronate sodium [18], insulin [19] and peptide [20]. These nanoparticles are delivered in severalapproachesincluding injection drug delivery [21], topical drug delivery [22], colon-targeted drug delivery [23], carcinoma therapy [24] and gene delivery [25].…”

Section: Chitosan In Nanosciencementioning

confidence: 99%

Chitosan as a Natural Copolymer with Unique Properties for the Development of Hydrogels

et al. 2019

View full text Add to dashboard Cite

Hydrogel-based polymers are represented by those hydrophilic polymers having functional groups in their chain such as amine (NH2), hydroxyl [-OH], amide (-CONH-, -CONH2), and carboxyl [COOH]. These hydrophilic groups raise their potential to absorb fluids or aqueous solution more than their weights. This physicochemical mechanism leads to increased hydrogel expansion and occupation of larger volume, the process which shows in swelling behavior. With these unique properties, their use for biomedical application has been potentially raised owing also to their biodegradability and biocompatibility. Chitosan as a natural copolymer, presents a subject for hydrogel structures and function. This review aimed to study the structure as well as the function of chitosan and its hydrogel properties.

show abstract

Enhancement of alendronate encapsulation in chitosan nanoparticles

Cited by 60 publications

References 29 publications

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

Evaluation of the mucoadhesive properties of chitosan nanoparticles prepared using different chitosan to tripolyphosphate (CS:TPP) ratios

Chitosan as a Natural Copolymer with Unique Properties for the Development of Hydrogels

Contact Info

Product

Resources

About