Enhancement of anti-acne effect of Scutellaria baicalensis extract by fermentation with symbiotic fungus Penicillium decumbens

Zhu, Xiaojing; Mao, Yue; Guo, Miaomiao; Yu, Haiyuan; Hao, Liling; Hua, Qiang; Lu, Zhi Zhen; Hong, Minhua; An, Faliang

doi:10.1016/j.jbiosc.2020.06.008

Cited by 10 publications

(7 citation statements)

References 42 publications

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“…Next, they devised an eco-friendly strategy, namely fermentation of plant extracts by the symbiotic fungus Penicillium decumbens f3-1, to convert the glycoside into its aglycone (conversion rate = 91% in 4 days). In contrast, no significant anti-acne potential (IL-1β inhibition rate < 50%) was detected for the second most abundant flavonoid in the extracts and its glycoside, namely baicalein and baicalin [18].…”

Section: Lamiaceaementioning

confidence: 78%

Bioactive Compounds from Natural Sources as Potential Adjuvants in the Treatment of Mild Acne Vulgaris

Cristani,

Micale

2024

Preprint

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In recent years, there has been a growing interest in the use of medicinal plants and phytochemicals as potential treatments for acne vulgaris. This condition, characterized by chronic inflammation, predominantly affects adolescents and young adults. Conventional treatment typically targets the key factors contributing to its development: the proliferation of Cutibacterium acnes and the associated inflammation. However, these treatments often involve the use of potent drugs. As a result, the exploration of herbal medicine as a complementary approach has emerged as a promising strategy. By harnessing the therapeutic properties of medicinal plants and phytochemicals, it may be possible to address acne vulgaris while minimizing the reliance on strong drugs. This approach not only offers potential benefits for individuals seeking alternative treatments but also underscores the importance of natural remedies in dermatological care. The primary aim of this study was to assess the antimicrobial, antioxidant, and anti-inflammatory properties of plants and their phytochemical constituents in the management of mild acne vulgaris. A comprehensive search of scientific databases was conducted from 2018 to September 2023. The findings of this review suggest that medicinal plants and their phytochemical components hold promise as treatments for mild acne vulgaris. However, it is crucial to note that further research employing high-quality evidence and standardized methodologies is essential to substantiate their efficacy and safety profiles.

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Section: Lamiaceaementioning

confidence: 78%

Bioactive Compounds from Natural Sources as Potential Adjuvants in the Treatment of Mild Acne Vulgaris

Cristani,

Micale

2024

Preprint

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“…Recently, wogonin has been found to significantly inhibit the expression of IL-1β and IL-8 in THP-1 cells induced by Pseudomonas acne, alleviate the inflammatory response induced by Pseudomonas acne, and has strong anti-acne activity. [ 54 ] Wogonin can also inhibit the phosphorylation of MAPKs and the translocation of nuclear factor-kB. [ 54 ] Naringenin is a polyphenol phytochemical, which is widely distributed in citrus fruits.…”

Section: Discussionmentioning

confidence: 99%

“…[ 54 ] Wogonin can also inhibit the phosphorylation of MAPKs and the translocation of nuclear factor-kB. [ 54 ] Naringenin is a polyphenol phytochemical, which is widely distributed in citrus fruits. Naringenin has anticancer, antioxidant and anti-inflammatory pharmacological properties.…”

Section: Discussionmentioning

confidence: 99%

Identification of biomarkers of acne based on transcriptome analysis and combined with network pharmacology to explore the therapeutic mechanism of Jinhuang ointment

Li,

Gao,

Miao

et al. 2023

Medicine

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The incidence of acne is on the rise due to unhealthy diet and living habits. Jinhuang ointment (JHO) is a classic prescription composed of 10 kinds of commonly used Chinese herbal medicine, which has been widely used in clinical prevention and treatment of skin inflammatory diseases since ancient times. However, the pharmacological mechanism and target of JHO are not clear. The acne microarray dataset was downloaded from gene expression omnibus database to identify differentially expressed genes (DEG). Immune infiltration was analyzed by CiberSort algorithm. HUB gene was identified by protein-protein interaction network. The gene expression omnibus dataset validates the biomarkers of acne with high diagnostic value. The potential active components and targets of JHO were obtained through Traditional Chinese Medicine Systems Pharmacology database, and the therapeutic targets were obtained by crossing with disease targets. R-packet is used for enrichment analysis. Molecular docking using Auto Dock Tools. A total of 202 DEGs were identified from 12 skin samples in the GSE6475. Immune infiltration analysis showed that there were a large number of macrophages and mast cells in acne skin. Gene set enrichment analysis analysis showed that DEGS was mainly involved in bacterial reaction, inflammatory reaction and so on. Six central genes and gene cluster modules were identified by Cytoscape software. A total of 185 JHO active components and 220 targets were obtained, of which 10 targets were potential targets for JHO in the treatment of acne. Kyoto encyclopedia of genes and genomes enrichment analysis showed that JHO treatment of acne was mainly related to Toll-like receptors, IL-17 and other signal pathways. The results of molecular docking showed that 5 active compounds in JHO had strong binding activity to the core protein receptor. IL-1 β, CXCL8, toll-like receptor 2, CXCL2, LCN2, and secretory phosphoprotein 1 may be potential biomarkers for early diagnosis of acne. JHO active components may regulate skin cell metabolism and inflammatory response and improve cellular immune microenvironment by acting on core targets (CXCL8, ESR1, IL-1 β, MMP1, MMP3, secretory phosphoprotein 1), thus achieving the purpose of treating acne. This is the result of the joint action of multiple targets and multiple pathways. It provides an idea for the development of a new combination of drugs for the treatment of acne.

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“…T. sinensis is known to have antibacterial and anti-inflammatory activities, and commonly used as a natural herbal medicine for treating dysentery, enteritis, and itchiness [3]. However, the anti-inflammatory effects of TS on P. acnes-induced inflammation disease remain unknown.…”

Section: Anntioxidant Effects Of Ts Extractmentioning

confidence: 99%

“…Acne is one of the most common skin diseases globally, affecting approximately 650 million adolescents and adults [1,2]. Acne is a chronic inflammatory disease which causes skin redness, itching, and inflammation [3]. Although the exact causes of acne remain unclear, environmental factors such as heredity, diet, stress, hormonal imbalance, and a narrow equilibrium between Propioninbacterium acnes (P. acnes) and other skin flora might play important roles in acne onset [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activities of an Extract of In Vitro Grown Adventitious Shoots of Toona sinensis in LPS-Treated RAW264.7 and Propionibacterium acnes-Treated HaCaT Cells

Lim

Park

Jie

et al. 2020

Plants

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Toona sinensis has been traditionally used to treat dysentery, enteritis, flatulence, and itchiness. However, the existence of anti-inflammatory effects of T. sinensis on Propionibacterium acnes-induced skin disease is unknown. In vitro cultures of plant cells and tissues produced under controlled conditions offer a continuous production platform for plant natural products including pigments and anti-inflammatory agents. In this study, we determine the anti-inflammatory activities of an extract of in vitro grown adventitious shoots of T. sinensis on P. acnes, the etiologic agent of skin inflammation. The extract of T. sinensis showed antioxidant and anti-inflammatory activity in LPS-treated RAW264.7 cells. It also had antibacterial activity and anti-inflammatory effects on P. acnes-treated HaCaT cells. In addition, these effects were regulated by suppression of the mitogen-activated protein kinase (MAPK) pathways. These results suggesting the potential application of adventitious shoots of T. sinensis grown with an in vitro proliferation system as a medicine for treating P. acnes-induced inflammatory skin disease.

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Enhancement of anti-acne effect of Scutellaria baicalensis extract by fermentation with symbiotic fungus Penicillium decumbens

Cited by 10 publications

References 42 publications

Bioactive Compounds from Natural Sources as Potential Adjuvants in the Treatment of Mild Acne Vulgaris

Bioactive Compounds from Natural Sources as Potential Adjuvants in the Treatment of Mild Acne Vulgaris

Identification of biomarkers of acne based on transcriptome analysis and combined with network pharmacology to explore the therapeutic mechanism of Jinhuang ointment

Anti-Inflammatory Activities of an Extract of In Vitro Grown Adventitious Shoots of Toona sinensis in LPS-Treated RAW264.7 and Propionibacterium acnes-Treated HaCaT Cells

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