Enhancement of anti-leukemic potential of 2-hydroxyphenyl-azo-2′-naphthol (HPAN) on MOLT-4 cells through conjugation with Cu(ii)

Influence of ionic strength on the interaction of THA and its Cu(ii) complex with DNA helps to explain studies on various breast cancer cells

“…The comet assay was performed since it is a more direct assay to study genotoxic effects of any substance. 23,49 Therefore, considering a probable enhanced cellular uptake of the complex followed by an effective binding of it with the DNA of the cells Cu II purpurin was able to induce greater DNA damage as observed in the comet assay. At the IC 50 dose of the complex, DNA damage was absent for purpurin.…”

CuIIcomplex of emodin with improved anticancer activity as demonstrated by its performance on HeLa and Hep G2 cells

“…[16][17][18][19][20] This is one of the major reasons why copper complexes of anticancer agents have been so successful and shown superior anticancer activity to the anticancer agent itself, the one from which the complex was prepared. 6,9,10,[16][17][18]20 In the majority of cases, once inside the cell, it is the anticancer agent present in the complex that is benecial for the anticancer action. However, its increased presence in the cell, an important criterion for efficacy, is because the copper complex has enhanced its cellular uptake.…”

“…[9][10][11][12][13][14][15] In the process, the anticancer agent linked to the metal ion is able to enter the cancer cell much more easily than on its own and can then initiate cell damage, thus showing anticancer activity. [16][17][18] Once within the cell, this happens for the anticancer agent in a state bound to the metal ion or by dissociating from it inside the cell. 16 Thus, by using a copper complex of an anticancer agent, the cell can be tempted to procure copper ions, thereby in the process assimilating the anticancer agent that will eventually kill it by disturbing one or more of the cellular pathways that help these cells to survive.…”

“…16 Thus, by using a copper complex of an anticancer agent, the cell can be tempted to procure copper ions, thereby in the process assimilating the anticancer agent that will eventually kill it by disturbing one or more of the cellular pathways that help these cells to survive. [16][17][18]20 Besides, the complexes have various other attributes that are most oen not known for the ligand (the anticancer agent). Owing to this, their efficacy far exceeds that of the anticancer agent itself.…”

“…The results were analyzed using eqn (S1)-(S5), ESI. † [16][17][18][19][20][29][30][31][32][33] 2.4.2 At different temperatures for evaluation of the thermodynamic parameters. Titration of the compounds with DNA was performed at four different temperatures at a constant pH ($7.87) and ionic strength of the medium.…”