2020
DOI: 10.1155/2020/4805706
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Enhancement of Antibacterial Activity of Paludifilum halophilum and Identification of N-(1-Carboxy-ethyl)-phthalamic Acid as the Main Bioactive Compound

Abstract: The aim of this study was to determine the combined effect of fermentation parameters and enhance the production of cellular biomass and antibacterial compounds from Paludifilum halophilum SMBg3 using the response surface methodology (RSM). Eight variables were screened to assess the effects of fermentation parameters on growth and metabolite production by Taguchi experimental design. Among these, the initial pH, temperature, and the percentage of MgSO4·7H2O in the medium were found to be most influential. The… Show more

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“…According to Dammak et al based on the HRE-SI-MS spectral data, the cyclic lipopeptide Gramicidin S and four cyclic dipeptides were detected in the fermentation broth of Paludifilum halophilum , a new genus of the Thermoactinomycetaceae family isolated from the surface sediment of a sun saline with antimicrobial activity against S. aureus and other pathogenic bacteria ( 29 ). Later, in 2020, Dammak et al discovered N-(1-carboxy-ethyl)-phthalamic Acid as the first secondary metabolite from Paludifilum halophilum with antibacterial activity ( 30 ).…”
Section: Discussionmentioning
confidence: 99%
“…According to Dammak et al based on the HRE-SI-MS spectral data, the cyclic lipopeptide Gramicidin S and four cyclic dipeptides were detected in the fermentation broth of Paludifilum halophilum , a new genus of the Thermoactinomycetaceae family isolated from the surface sediment of a sun saline with antimicrobial activity against S. aureus and other pathogenic bacteria ( 29 ). Later, in 2020, Dammak et al discovered N-(1-carboxy-ethyl)-phthalamic Acid as the first secondary metabolite from Paludifilum halophilum with antibacterial activity ( 30 ).…”
Section: Discussionmentioning
confidence: 99%