Enhancement of antioxidant and anti-inflammatory activities of bioflavonoid rutin by complexation with transition metals

Afanas’eva, Igor B; Ostrakhovitch, Elena A.; Mikhalchik, Elena V.; Ibragimova, G. A.; Korkina, Liudmila

doi:10.1016/s0006-2952(01)00526-3

Cited by 183 publications

(93 citation statements)

References 21 publications

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“…The flavonoids 7-9 were identified based on NMR data (Hansen et al, 1999;Galotta et al, 2008) and typical fragmentation by CID experiments with ESI-MS (Fabre et al, 2001). Some biological activities reported for the isolated flavonoids are: antidepressant for rutin (Nolder & Schotz, 2002), anti-inflammatory for rutin and quercetin (Afanaseva et al, 2001) and antioxidant for all of them (Galotta et al, 2008). The flavonol quercetin is ubiquitous in monocotyledons, so it cannot be used as marker of the Arecaceae family (Silva, 2007).…”

Section: Resultsmentioning

confidence: 99%

Triterpenes and flavonoids from the roots of Mauritia flexuosa

Koolen¹,

Soares²,

Silva³

et al. 2012

Rev. bras. farmacogn.

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Mauritia flexuosa L. f., Arecaceae, is an endemic species of South America. This species was studied with the intent to isolate the constituents of its roots. After the fractionation of the n-hexane and methanolic extracts from the roots of M. flexuosa, six triterpenes were obtained: friedelin, taraxerone, lupenyl acetate, lupenone, betulin and betulinic acid, along with three flavonoids: rutin, quercitrin and quercetin. All the compounds were identified by analysis of NMR and MS data and comparison with the literature. All those compounds are been reported for the first time in Mauritia, and the chemosystematic significance of the flavonoids isolated in this genus is discussed.

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Section: Resultsmentioning

confidence: 99%

Triterpenes and flavonoids from the roots of Mauritia flexuosa

Koolen¹,

Soares²,

Silva³

et al. 2012

Rev. bras. farmacogn.

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“…It has a protective effect against development of diabetes and mitigates the effects on the consequences of diabetes (Je et al 2002;Srinivasan et al 2005). Moreover, it has antioxidative and anti-platelet formation properties as well (Afanas'eva et al 2001;Sheu et al 2004). In addition, it has a mitigating effect on cardiovascular diseases (He et al 1995), it has also anticancer activity (Giménez-Bastida and Zieliński 2015) and antimutagenic activity (Brindzova et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Rutin in buckwheat grain meal determined by UV photoacoustic spectroscopy and HPLC

Dóka¹,

Brunori²,

Schmidt³

et al. 2017

Nova Biotechnologica Et Chimica

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A relatively novel approach for easy and quick determination of rutin in buckwheat grain is suggested. The rutin content of the grain in seven common buckwheat (Fagopyrum esculentum) and six Tartary buckwheat (Fagopyrum tataricum) varieties was investigated by means of UV photoacoustic spectroscopy and HPLC as reference method. The lowest content was found in 'Botan' and 'Bamby' varieties, while the highest values were obtained in the variety 'Emka'. Rutin content in grain of all Tartary buckwheat varieties was two orders of magnitude higher than in the other varieties. Rutin content in F. esculentum ranges between 9 and 36 mg/100 g dry weight as compared to 921 to 2 132 mg/100 g dry weight in F. tataricum. The UV photoacoustic spectroscopy data show rather good correlations of R 2 =0.977 and R 2 =0.980 with values obtained by HPLC data for all measured samples. Therefore, UV photoacoustic spectroscopy can be a cheap and quick method for determining rutin content in buckwheat grain.

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“…Besides the widely recognised positive effect on capillary fragility and permeability, rutin is reported to have an antihyperglycaemic effect (Wang et al, 1992;Kamalakkannan and Stanely Mainzen, 2006), a protective effect against the development of diabetes (Odetti et al, 1990;Srinivasan et al, 2005), a mitigating effect on the consequences of diabetes (Je et al, 2002;Nagasawa et al, 2003), antioxidative properties (Oomah and Maza, 1996;Afanas'eva et al, 2001), anti-inflammatory activity (Guardia et al, 2001), anti-platelet formation properties (Sheu et al, 2004), a mitigating effect on cardiovascular diseases (He 266 et al, 1995), anticancer activity and antimutagenic activity (Aheme and O'Brien, 1999;2000;Undeger et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Rutin content of the grain of buckwheat ( Fagopyrum esculentum Moench. and Fagopyrum tataricum Gaertn.) varieties growtn in southern Italy

Brunori

Végvári

2007

Acta Agronomica Hungarica

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The rutin content of the grain of 31 buckwheat varieties (28 F. esculentum and 3 F. tataricum ) grown on the high plain of Sila (Region of Calabria) and on the massif of Pollino (Region of Basilicata) presented a substantial degree of variation.Among the F. esculentum varieties the lowest values were found for Botan and Spacinska, while the highest contents were observed in the varieties Emka and Lechnicka Krajova. As expected, the rutin content of the grain of F. tataricum was higher than that of F. esculentum , with the variety Donan showing the highest value.In view of the role of rutin in conferring most of the functional food characteristics of buckwheat, knowledge of the grain rutin content expressed in a specific environment, together with the yield potential, is important for the identification of buckwheat varieties worth adopting in an area such as the high plain of Sila, which, thanks to its extent, has the potential to represent a novel territory for the profitable cultivation of buckwheat in Italy.

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Enhancement of antioxidant and anti-inflammatory activities of bioflavonoid rutin by complexation with transition metals

Cited by 183 publications

References 21 publications

Triterpenes and flavonoids from the roots of Mauritia flexuosa

Triterpenes and flavonoids from the roots of Mauritia flexuosa

Rutin in buckwheat grain meal determined by UV photoacoustic spectroscopy and HPLC

Rutin content of the grain of buckwheat ( Fagopyrum esculentum Moench. and Fagopyrum tataricum Gaertn.) varieties growtn in southern Italy

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