Enhancement of antiradical properties of dihydroquercetin by nitrosation

Gogotov, A. F.; Kanitskaya, L. V.; Hai, Dam Thi Thanh; Ostroukhova, L. A.; Tai, Do Chiem; Bitukheeva, E. A.; Shaposhnikova, A. N.; Babkin, V. A.; Stankevich, V. K.

doi:10.1134/s1070427214120143

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…5. Based on the reported data for structurally defined DHQ, 25,26 the DHQ spectrum (Fig. 5A) is obviously characterized by the signals at 71.6, 83.1, and 197.8 ppm, which are attributed to C3, C2, and C4 of ring C, respectively.…”

Section: H and 13 C Nmr Analysismentioning

confidence: 88%

“…The hydrogen atoms of the OH groups of DHQ could be observed at 5.72 ppm (3-OH), 8.95 ppm (4′-OH), 9.00 ppm (3′-OH), 10.80 ppm (7-OH) and 11.88 ppm (5-OH), thereby confirming the structure of DHQ. 25,26 The number and positions of the strong signals in the 1 H-NMR spectra of DHQA (Fig. 4B) considerably changed compared with those in the spectra of DHQ.…”

Section: H and 13 C Nmr Analysismentioning

confidence: 95%

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Synthesis, characterization, solubilization, cytotoxicity and antioxidant activity of aminomethylated dihydroquercetin

Dong

Ouyang

et al. 2017

Med. Chem. Commun.

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A dihydroquercetin derivative (DHQA) was prepared through aminomethylation to overcome the low water solubility and bioavailability of dihydroquercetin (DHQ). DHQA was characterized through HPLC, nuclear magnetic resonance, scanning electron microscopy, X-ray diffraction, and thermogravimetric analyses. DHQA was converted into the amorphous form, but the major structure of DHQ remained unchanged. Solubilization and dissolution tests were also performed. Results showed that the solubility and dissolution rates of DHQA were approximately 16.28 and 6.31 times higher than those of DHQ, respectively. The MTT assay of DHQA showed a non-toxic effect against non-cancerous HEK-293T cells (EC = 820.00 μM), and potent inhibitory activity against cancerous Hela cells (EC = 138.17 μM). Finally, the antioxidant activity of DHQA was confirmed through DPPH and ABTS radical scavenging activity assays. DHQA displayed high antioxidant activities with low IC values (0.043 and 0.042 mM, respectively). Reducing Fe power assay indicated that DHQA exhibited higher reducing power than DHQ and ascorbic acid.

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Section: H and 13 C Nmr Analysismentioning

confidence: 88%

Section: H and 13 C Nmr Analysismentioning

confidence: 95%

Synthesis, characterization, solubilization, cytotoxicity and antioxidant activity of aminomethylated dihydroquercetin

Dong

Ouyang

et al. 2017

Med. Chem. Commun.

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“…Moreover, the trans form of flavanone is more chemically active. DHQ has a high P vitamin activity, exhibits antioxidant activity, is resistant to autooxidation, and is a low toxic substance (Gogotov et al, 2014). The mechanism of antioxidant action is to neutralize the action of active oxygen and nitrogen molecules by preventing lipid peroxidation and the formation of chelate complexes with metals.…”

Section: Introductionmentioning

confidence: 99%

Dihydroquercetin increases the adaptive potential of wild soybean against copper sulfate and cadmium sulfate toxicity

Чернышук¹,

Ivachenko²,

Doğan³

et al. 2020

Turk J Agric For

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Recently, soil contamination of agricultural land by heavy metals has become a serious problem (Miransari, 2016; Zhang et al., 2018). Cadmium (Cd) is a toxic element for plants. Cd can inhibit plant growth, development, and productivity by disrupting amino acid biosynthesis, inhibiting enzyme activity, interfering with mineral nutrition, and metabolic imbalances (Liu et al., 2015a; Yang et al., 2018). Copper (Cu) is essential as a plant microelement but in excess amounts it becomes highly toxic and inhibits photosynthesis (Dey et al., 2014), nutrient uptake, plant growth (Adrees et al., 2015), and ultimately causes cell death (Printz et al., 2016). In addition, excessive amounts of heavy metals induce oxidative stress, causing an increased formation of reactive oxygen species (ROS)

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Enhancement of antiradical properties of dihydroquercetin by nitrosation

Cited by 2 publications

References 9 publications

Synthesis, characterization, solubilization, cytotoxicity and antioxidant activity of aminomethylated dihydroquercetin

Synthesis, characterization, solubilization, cytotoxicity and antioxidant activity of aminomethylated dihydroquercetin

Dihydroquercetin increases the adaptive potential of wild soybean against copper sulfate and cadmium sulfate toxicity

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