Enhancement of bone consolidation in mandibular distraction osteogenesis: A contemporary review of experimental studies involving adjuvant therapies

Hong, Paul; Boyd, Daniel; Beyea, Steven; Bezuhly, Michael

doi:10.1016/j.bjps.2013.03.030

Cited by 35 publications

(34 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the long-term stability of the results obtained with DO only is not well documented, and reports of instability and relapse can be found in the literature. 2,3 The gradual tension applied to the fracture gap activates the transformation of mesenchymal cells into osteoblasts and fibroblasts secreting type I collagen, which is organized into fibrils. 4 The periosteal and endosteal surfaces on either side of the fracture gap are rapidly revascularized, and woven bone extends rapidly into the collagen fibrils.…”

mentioning

confidence: 99%

Evaluation of the effect of low-level diode laser therapy applied during the bone consolidation period following mandibular distraction osteogenesis in the human

Abd-Elaal

El-Mekawii

Saafan

et al. 2015

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

mentioning

confidence: 99%

Evaluation of the effect of low-level diode laser therapy applied during the bone consolidation period following mandibular distraction osteogenesis in the human

Abd-Elaal

El-Mekawii

Saafan

et al. 2015

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

“…Several GFs are known to enhance bone regeneration, including transforming GF beta family members, fibroblast GFs, vascular endothelial GF, and platelet-derived GF (Cillo et al, 2000). BMP-2 and BMP-7 have been described in clinical use for induction of bone formation in alveolar ridge and sinus augmentation and the repair of critical-sized defects of craniofacial bones (Dickinson et al, 2008;Yuan et al, 2012;Hong et al, figure 2. Anatomically shaped scaffolds.…”

Section: Enhancing Regenerative Capacity Of Biomaterials: Growth Factorsmentioning

confidence: 99%

Biomaterials for Craniofacial Bone Engineering

et al. 2014

View full text Add to dashboard Cite

Conditions such as congenital anomalies, cancers, and trauma can all result in devastating deficits of bone in the craniofacial skeleton. This can lead to significant alteration in function and appearance that may have significant implications for patients. In addition, large bone defects in this area can pose serious clinical dilemmas, which prove difficult to remedy, even with current gold standard surgical treatments. The craniofacial skeleton is complex and serves important functional demands. The necessity to develop new approaches for craniofacial reconstruction arises from the fact that traditional therapeutic modalities, such as autologous bone grafting, present myriad limitations and carry with them the potential for significant complications. While the optimal bone construct for tissue regeneration remains to be elucidated, much progress has been made in the past decade. Advances in tissue engineering have led to innovative scaffold design, complemented by progress in the understanding of stem cell-based therapy and growth factor enhancement of the healing cascade. This review focuses on the role of biomaterials for craniofacial bone engineering, highlighting key advances in scaffold design and development.

show abstract

“…11-13 The DO procedure involves three sequential phases: latency; active distraction or lengthening; and consolidation. 14,15 It stimulates new bone formation through the controlled separation of two osteogenic fronts and also promotes the regeneration of the surrounding soft tissue. 16,17 DO resembles an in vivo form of tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

“…5,17,23 During this period complications can arise including pin site infection and fibrous union; patients and family members may experience physical inconvenience and psychosocial burden due to the retained external fixators, and there is a higher rate of fracture at the docking site. 14,24-26 These limitations hamper any large-scale clinical application of DO. The recommended rate of gradual bone lengthening as described by Ilizarov is 1 mm per day.…”

Section: Introductionmentioning

confidence: 99%

Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis

Yang

Lin

Wang

et al. 2017

Bone & Joint Research

View full text Add to dashboard Cite

ObjectivesDistraction osteogenesis (DO) mobilises bone regenerative potential and avoids the complications of other treatments such as bone graft. The major disadvantage of DO is the length of time required for bone consolidation. Mesenchymal stem cells (MSCs) have been used to promote bone formation with some good results.MethodsWe hereby review the published literature on the use of MSCs in promoting bone consolidation during DO.ResultsStudies differed in animal type (mice, rabbit, dog, sheep), bone type (femur, tibia, skull), DO protocols and cell transplantation methods.ConclusionThe majority of studies reported that the transplantation of MSCs enhanced bone consolidation or formation in DO. Many questions relating to animal model, DO protocol and cell transplantation regime remain to be further investigated. Clinical trials are needed to test and confirm these findings from animal studies.Cite this article: Y. Yang, S. Lin, B. Wang, W. Gu, G. Li. Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies. Bone Joint Res 2017;6:385–390. DOI: 10.1302/2046-3758.66.BJR-2017-0023.

show abstract

Enhancement of bone consolidation in mandibular distraction osteogenesis: A contemporary review of experimental studies involving adjuvant therapies

Cited by 35 publications

References 68 publications

Evaluation of the effect of low-level diode laser therapy applied during the bone consolidation period following mandibular distraction osteogenesis in the human

Evaluation of the effect of low-level diode laser therapy applied during the bone consolidation period following mandibular distraction osteogenesis in the human

Biomaterials for Craniofacial Bone Engineering

Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis

Contact Info

Product

Resources

About