Enhancement of carbachol-induced amylase secretion in parotid glands from rats with experimental periodontitis

Morphological changes in the salivary acini after in vivo cholinergic stimulation

“…These findings supported those of Lundquist and Norberg, who found widespread vacuolations in the cytoplasm of both serous and mucus acini when they used carbachol as a cholinergic agonist. Possible mechanisms for this outcome were suggested by Busch and Borda, who found carbachol increased accumulation of inositol phosphate in the salivary glands, and by Miozza et al, who found carbachol improved the fusion/exocytosis process inside the secretory vesicles by a calcium‐agonistic effect on cyclic adenosine monophosphate. Other studies also found increased salivary secretion from the submandibular gland, which suggest the recovery of secretomotor activity of the salivary gland acini after early stages of peripheral nerve injury may result from regeneration of damaged axons.…”

Efeito do tratamento periodontal não cirúrgico na atividade da peroxidase na saliva da glândula parótida e no fluído gengival

“…Uma das possíveis vias para resultar neste fenômeno pode estar relacionada à produção elevada de prostaglandinas (PGE-2) no periodonto destes pacientes, assim como demonstraram o aumento deste mediador inflamatório associado ao aumento dos níveis de NOS e amilase em saliva de parótida de ratos com periodontite experimental (Miozza et al, 2010;Miozza et al, 2011). Sabe-se que as prostaglandinas são mediadores inflamatórios da doença periodontal.…”