2019
DOI: 10.1016/j.biopha.2019.109185
|View full text |Cite
|
Sign up to set email alerts
|

Enhancement of chemosensitivity by WEE1 inhibition in EGFR-TKIs resistant non-small cell lung cancer

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
6
0

Year Published

2020
2020
2025
2025

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 12 publications
(6 citation statements)
references
References 39 publications
0
6
0
Order By: Relevance
“…Inhibition of WEE1 was the result of circ‐SNAP47 interference and/or miR‐625‐5p re‐expression, both of which resulted in the sensitization of DDP‐tolerant NSCLC cells to DDP. A previous report claimed an enhancement of chemosensitivity by WEE1 inhibition in epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKIs)‐resistant NSCLC cells, as evidenced by that WEE1 shRNA enhanced the sensitivity of DDP and gefitinib in H1299 cells (intrinsic gefitinib resistance) and PC9/G2 cells (acquired gefitinib resistance) 29 . Furthermore, AZD1775, a small molecule against WEE1, could be used as monotherapy or combination therapy in NSCLC to enhance radiosensitization and suppress chemoresistance 30,31 .…”
Section: Discussionmentioning
confidence: 99%
“…Inhibition of WEE1 was the result of circ‐SNAP47 interference and/or miR‐625‐5p re‐expression, both of which resulted in the sensitization of DDP‐tolerant NSCLC cells to DDP. A previous report claimed an enhancement of chemosensitivity by WEE1 inhibition in epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKIs)‐resistant NSCLC cells, as evidenced by that WEE1 shRNA enhanced the sensitivity of DDP and gefitinib in H1299 cells (intrinsic gefitinib resistance) and PC9/G2 cells (acquired gefitinib resistance) 29 . Furthermore, AZD1775, a small molecule against WEE1, could be used as monotherapy or combination therapy in NSCLC to enhance radiosensitization and suppress chemoresistance 30,31 .…”
Section: Discussionmentioning
confidence: 99%
“…In addition, it has been unearthed that WEE1 protein level is upregulated in colorectal cancer liver metastasis endothelial cells, and the cell functional activities are impaired as affected by silenced WEE1 (Garcia-Rodriguez et al, 1989). Another study has also confirmed the high-expressed WEE1 in non-resectable non-small lung cancer; furthermore, WEE1 deletion makes a contribution to enhance the efficacy of cisplatin and gemcitabine for the therapy of lung cancer (Liu et al, 2019). All these articles validated the stimulative function of WEE1 in human cancers.…”
Section: Discussionmentioning
confidence: 99%
“…DNA repair mechanisms are considered as a significant contributor to resistance against DNA damage therapies (Dibitetto et al 2022 ). WEE1 suppression could overcome resistance to EGFR-TKIs inhibitors and enhance the efficacy of cisplatin and gemcitabine (Liu et al 2019 ). Additionally, Li et al ( 2020b ) demonstrated the significant impact of the DGKA-c-Jun-WEE1 signaling axis on platinum sensitivity in platinum-resistant ovarian cancer cells.…”
Section: Wee1 and Cancermentioning
confidence: 99%