2014
DOI: 10.1002/jbm.a.35370
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Enhancement of chondrocyte proliferation, distribution, and functions within polycaprolactone scaffolds by surface treatments

Abstract: Enhancement of porcine chondrocyte growth, distribution and functions within polycaprolactone (PCL) scaffolds was attempted using alkaline hydrolysis and oxygen plasma treatment. The hydrolysis of PCL was performed either before or after scaffold fabrication in the preparations of pre-hydrolyzed PCL (pre-HPCL) or post-HPCL scaffolds, respectively. The PCL, pre-HPCL, and post-HPCL scaffolds were subsequently plasma-treated to yield plasma-treated PCL, plasma-treated pre-HPCL, and plasma-treated post-HPCL scaffo… Show more

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Cited by 15 publications
(9 citation statements)
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“…Polycaprolactone (PCL) is a synthetic biodegradable and biocompatible polyester with good mechanical properties, high plasticity, non-toxicity and gradual resorption following implantation [ 5 ]. Despite the lack of bioactive functional groups and the hydrophobic character of PCL, several studies propose the use of PCL scaffolds to promote the proliferation of cells and extracellular matrix production [ 17 , 18 , 19 ]. PCL copolymers and blends with other natural or synthetic polymers have been frequently used as a biocompatible material both in soft and hard tissue engineering applications including cartilage and bone regeneration [ 18 , 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…Polycaprolactone (PCL) is a synthetic biodegradable and biocompatible polyester with good mechanical properties, high plasticity, non-toxicity and gradual resorption following implantation [ 5 ]. Despite the lack of bioactive functional groups and the hydrophobic character of PCL, several studies propose the use of PCL scaffolds to promote the proliferation of cells and extracellular matrix production [ 17 , 18 , 19 ]. PCL copolymers and blends with other natural or synthetic polymers have been frequently used as a biocompatible material both in soft and hard tissue engineering applications including cartilage and bone regeneration [ 18 , 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, the use of PCL as a cell-compatible and cell-instructive material for AC tissue regeneration is still hindered by its slow degradation rate (i.e., from six to thirty six months as a function of molecular weight), release of acidic by-products and poor biomechanical performance [ 18 ]. Additionally, PCL scaffolds often have to be surface treated to increase hydrophilicity in order to maintain chondrocyte phenotype [ 25 ]. Biodegradable and bioabsorbable α-amino acid based poly(ester urea)s (AA-PEUs)have been proposed as a new class of polymers with enhanced bioactivity for TE [ 26 , 27 ].…”
Section: Introductionmentioning
confidence: 99%
“…Cellular attachment in these materials is limited to the scaffold periphery in vitro and results in a poorly integrated scaffold in vivo. Monomer grafting (De Valence et al, ; Pappa et al, ; Siri, Wadbua, Amornkitbamrung, Kampa, & Maensiri, ), film deposition (Uppanan, Thavornyutikarn, Kosorn, Kaewkong, & Janvikul, ; Wulf et al, ), and tethering of bioactive molecules (Gabriel et al, ; Robinson et al, ; Yildirim et al, ) have all been used as methods of improving scaffold performance. However, it often is assumed that the surface modification chemistry proceeds in a similar uniformity to that seen on flat substrates.…”
Section: Introductionmentioning
confidence: 99%