Enhancement of chronic wound healing with maltodextrin/ascorbic acid gel: a clinical evaluation of distal limb wounds in horses

Abstract

Delayed healing associated with distal limb wounds is highly challenging in equine clinical practice. This study aimed to evaluate healing rates between chronic non-granulating wounds of horse distal limbs that were treated with maltodextrin/ascorbic acid gel alone or in combination with povidone-iodine 1% solution and those treated with povidone-iodine 1% only throughout the study period (35 days) in clinical settings. The study was conducted on 18 adult horses (3–15 years old). Based on the treatment regimen utilized, the horses were divided into three groups (n = 6), with each group having a similar mean wound area. The percentages of wound contraction, epithelialization, and overall wound healing were determined weekly for each wound. By the end of the study, the total wound healing percentage was significantly increased between the study groups ( p < 0.05). The use of maltodextrin/ascorbic acid gel resulted in considerable wound contraction, rapid epithelialization, and complication-free wound healing. Based on the findings of this study, maltodextrin/ascorbic acid gel, independently or in combination with a 1% povidone-iodine solution, might be applied as a safe and effective wound healing promoting agent in horses with chronic non-granulating wounds.

Clinical Effect of Mesenchymal Stem cell-Derived Microvesicles as Adjunctive Treatment to Surgery on Healing of Distal Limb Chronic Wounds in Arabian Horses

“…Therefore, open wounds at the distal extremities heal by secondary intention in most cases. In this type of wound healing, granulation tissue accumulates to fill the wound bed, followed by re-epithelialization and wound contraction [6,7]. However, if the open wounds become infected, several complications like delayed healing, bone sequestration, over granulating D Egyptian Journal of Veterinary Sciences https://ejvs.journals.ekb.eg/ tissue formation, scar tissue formation, and surrounding tissue infection may occur [8].…”

Biofilm Production by Critical Antibiotic-Resistant Pathogens from an Equine Wound

“…Unfortunately, for horses, wounds constitute one of the most prevalent emergency conditions [ 1 ]. By themselves, horses already present a challenge in wound healing in the distal limbs [ 2 , 3 ], mainly due to the anatomical characteristics of this region where there is a substantial loss of soft tissue, high skin tension, and movement [ 4 ]. As if all the suffering and discomfort caused to the animal were not enough, affected horses lose their economic value and become unfit for work for long periods, or in other cases, their athletic careers end [ 5 ].…”