Enhancement of dissolution rate and oral bioavailability in beagle dogs of oleanolic acid by adsorbing onto porous silica using supercritical carbon dioxide

Li, Yuanyuan; Liu, Hongzhuo; Guo, Bao-Hong; Li, Yun; Geng, Yajie; Zhao, Furong; Zhang, Tianhong

doi:10.1016/s1773-2247(14)50077-9

Cited by 17 publications

(7 citation statements)

References 20 publications

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“…Despite limited absorption, the recovery of intact OA and UA has been reported in animal [ 53 , 54 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ] and human [ 67 , 68 , 69 ] plasma after oral and parenteral administration. Nonetheless, several pharmacokinetic studies revealed that maximal plasma concentration following oral administration of doses up to 300 mg/kg was low (at nanogram quantities) and elimination half-life was relatively short (<1 h) [ 54 , 60 , 63 , 69 ].…”

Section: Bioavailability and Pharmacokinetic Properties Of Ursolic And Oleanolic Acidsmentioning

confidence: 99%

Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential

Gudoityte

Arandarčikaitė

Mažeikienė

et al. 2021

IJMS

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Ursolic and oleanolic acids are secondary plant metabolites that are known to be involved in the plant defence system against water loss and pathogens. Nowadays these triterpenoids are also regarded as potential pharmaceutical compounds and there is mounting experimental data that either purified compounds or triterpenoid-enriched plant extracts exert various beneficial effects, including anti-oxidative, anti-inflammatory and anticancer, on model systems of both human or animal origin. Some of those effects have been linked to the ability of ursolic and oleanolic acids to modulate intracellular antioxidant systems and also inflammation and cell death-related pathways. Therefore, our aim was to review current studies on the distribution of ursolic and oleanolic acids in plants, bioavailability and pharmacokinetic properties of these triterpenoids and their derivatives, and to discuss their neuroprotective effects in vitro and in vivo.

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Section: Bioavailability and Pharmacokinetic Properties Of Ursolic And Oleanolic Acidsmentioning

confidence: 99%

Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential

Gudoityte

Arandarčikaitė

Mažeikienė

et al. 2021

IJMS

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show abstract

“…Despite limited absorption, the recovery of intact OA and UA has been reported in animal [53,54,[58][59][60][61][62][63][64][65][66] and human [67][68][69] plasma after oral and parenteral administration. Nonetheless, several pharmacokinetic studies revealed that maximal plasma concentration following oral administration of doses up to 300 mg/kg was low (at nanogram quantities) and elimination half-life was relatively short (<1 h) [54,60,63,69].…”

Section: Bioavailability and Pharmacokinetic Properties Of Ursolic And Oleanolic Acidsmentioning

confidence: 99%

Ursolic and Oleanolic Acids: Plant Metabolites with Neuromodulatory Potential

Gudoityte¹,

Arandarčikaitė²,

Mažeikienė³

et al. 2021

Preprint

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Ursolic and oleanolic acids are secondary plant metabolites that are known to be involved in the plant defence system against water loss and pathogens. Nowadays these triterpenoids are also regarded as potential pharmaceutical compounds and there is mounting experimental data that either purified compounds or triterpenoid-enriched plant extracts exert various beneficial effects, including anti-oxidative, anti-inflammatory and anticancer, on model systems of both human or animal origin. Some of those effects have been linked to the ability of ursolic and oleanolic acids to modulate intracellular antioxidant systems and also inflammation- and cell death-related pathways. Therefore, our aim was to review the current knowledge about the distribution of ursolic and oleanolic acids in plants, bioavailability and pharmacokinetic properties of these triterpenoids and their derivatives, and to discuss their neuromodulatory effects in vitro and in vivo.

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“…Pharmacokinetic studies of oleanolic acid were carried out in beagle dog by Shi et al [ 87 ] and Li et al [ 88 ]. Shi et al [ 87 ] determined pharmacokinetic parameters of oleanolic acid after oral and intravenous administration of calenduloside E, a triterpene saponin of oleanolic acid conjugated with glucuronic acid, while Li et al [ 88 ] determined pharmacokinetic parameters of a solid dispersion of oleanolic acid prepared with fumed silica by a supercritical fluid technology ( Table 4 ). According to Shi et al [ 87 ], oleanolic acid was found in the plasma after administration of oral doses of calenduloside E, indicating its formation from its glucuronic acid conjugate.…”

Section: Bioavailability Of Pentacyclic Triterpenesmentioning

confidence: 99%

“…This conjugate undergoes biliary excretion and is transported through the bile to the gut where it is again hydrolyzed to oleanolic acid, and the cycle is repeated. On the basis of the AUC values ( Table 4 ), Li et al [ 88 ] concluded that the solid dispersion of oleanolic acid prepared with fumed silica bioavailability was 1.9-fold higher, as compared with commercial tablets.…”

Section: Bioavailability Of Pentacyclic Triterpenesmentioning

confidence: 99%

Pentacyclic Triterpene Bioavailability: An Overview of In Vitro and In Vivo Studies

et al. 2017

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Pentacyclic triterpenes are naturally found in a great variety of fruits, vegetables and medicinal plants and are therefore part of the human diet. The beneficial health effects of edible and medicinal plants have partly been associated with their triterpene content, but the in vivo efficacy in humans depends on many factors, including absorption and metabolism. This review presents an overview of in vitro and in vivo studies that were carried out to determine the bioavailability of pentacyclic triterpenes and highlights the efforts that have been performed to improve the dissolution properties and absorption of these compounds. As plant matrices play a critical role in triterpene bioaccessibility, this review covers literature data on the bioavailability of pentacyclic triterpenes ingested either from foods and medicinal plants or in their free form.

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Enhancement of dissolution rate and oral bioavailability in beagle dogs of oleanolic acid by adsorbing onto porous silica using supercritical carbon dioxide

Cited by 17 publications

References 20 publications

Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential

Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential

Ursolic and Oleanolic Acids: Plant Metabolites with Neuromodulatory Potential

Pentacyclic Triterpene Bioavailability: An Overview of In Vitro and In Vivo Studies

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