Enhancement of drug permeability across blood brain barrier using nanoparticles in meningitis

Nair, Keerthi G.; Velmurugan, Ramaiyan; Kumar, S. Sathesh

doi:10.1007/s10787-018-0468-y

Cited by 35 publications

(12 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With advances in the understanding of ncRNA function, exosomal ncRNAs will become attractive therapeutic targets for the treatment of gliomas. The BBB helps protect the brain, but it also creates difficulties in treating neurological disorders, including gliomas [115]. As double-layer phospholipid membrane vesicles with abundant bioactive molecules inside, exosomes exhibit distinct advantages as gene therapy delivery vectors.…”

Section: The Potential Application Of Exosomal Ncrnas In Antiglioma Tmentioning

confidence: 99%

Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications

et al. 2020

View full text Add to dashboard Cite

Gliomas are complex and heterogeneous brain tumors with poor prognosis. Glioma cells can communicate with their surroundings to create a tumor-permissive microenvironment. Exosomes represent a new means of intercellular communication by delivering various bioactive molecules, including proteins, lipids and nucleic acids, and participate in tumor initiation and progression. Noncoding RNAs (ncRNAs) including microRNA, longnoncoding RNA, and circular RNA, account for a large portion of human transcriptome and play important roles in various pathophysiological processes, especially in cancers. In addition, ncRNAs can be selectively packaged, secreted and transferred between cells in exosomes and modulate numerous hallmarks of glioma, such as proliferation, invasion, angiogenesis, immune-escape, and treatment resistance. Hence, the strategies of specifically targeting exosomal ncRNAs could be attractive therapeutic options. Exosomes are able to cross the blood brain barrier (BBB), and are readily accessible in nearly all types of human biofluids, which make them the promising biomarkers for gliomas. Additionally, given the biocompatibility of exosomes, they can be engineered to deliver therapeutic factors, such as RNA, proteins and drugs, to target cells for therapeutic applications. Here, we reviewed current research on the roles of exosomal ncRNAs in glioma progression. We also discussed their potential clinical applications as novel biomarkers and therapeutics.

show abstract

Section: The Potential Application Of Exosomal Ncrnas In Antiglioma Tmentioning

confidence: 99%

Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The advent of nanotechnology has created many opportunities in enhancing drug delivery across the BBB. The challenges in the permeation across the complex physiology of BBB in the pathological conditions can be met by exploiting the nanodimensional vehicles with large surface area [8]. Their enhanced stability after physical and chemical modifications creates endless possibilities for administering drugs across the BBB for inflammatory disorders.…”

Section: Nanomaterials: Applications In Meningitis and Bacterial Infection Of Brainmentioning

confidence: 99%

Progress in the Application of Nanoparticles and Graphene as Drug Carriers and on the Diagnosis of Brain Infections

et al. 2021

View full text Add to dashboard Cite

The blood–brain barrier (BBB) is the protective sheath around the brain that protects the sensitive microenvironments of the brain. However, certain pathogens, viruses, and bacteria disrupt the endothelial barrier and cause infection and hence inflammation in meninges. Macromolecular therapeutics are unable to cross the tight junctions, thereby limiting their bioavailability in the brain. Recently, nanotechnology has brought a revolution in the field of drug delivery in brain infections. The nanostructures have high targeting accuracy and specificity to the receptors in the case of active targeting, which have made them the ideal cargoes to permeate across the BBB. In addition, nanomaterials with biomimetic functions have been introduced to efficiently cross the BBB to be engulfed by the pathogens. This review focuses on the nanotechnology-based drug delivery approaches for exploration in brain infections, including meningitis. Viruses, bacteria, fungi, or, rarely, protozoa or parasites may be the cause of brain infections. Moreover, inflammation of the meninges, called meningitis, is presently diagnosed using laboratory and imaging tests. Despite attempts to improve diagnostic instruments for brain infections and meningitis, due to its complicated and multidimensional nature and lack of successful diagnosis, meningitis appears almost untreatable. Potential for overcoming the difficulties and limitations related to conventional diagnostics has been shown by nanoparticles (NPs). Nanomedicine now offers new methods and perspectives to improve our knowledge of meningitis and can potentially give meningitis patients new hope. Here, we review traditional diagnosis tools and key nanoparticles (Au-NPs, graphene, carbon nanotubes (CNTs), QDs, etc.) for early diagnosis of brain infections and meningitis.

show abstract

“…Under standard conditions, exosomes can carry different types of RNA such as miRNA, circRNA, and lncRNA, but they can also be used to carry therapeutical ncRNAs to glioma cells. The first attempt in that direction was recently made with miR-302-367 encapsulated in exosomes that, after administration, can repress GBM growth [ 190 , 191 ]. NcRNAs as possible therapeutical targets are presented in Table 5 .…”

Section: Diagnostic and Therapeutic Potential Of Ncrnasmentioning

confidence: 99%

Non-Coding RNAs in Brain Tumors, the Contribution of lncRNAs, circRNAs, and snoRNAs to Cancer Development—Their Diagnostic and Therapeutic Potential

Latowska

Grabowska

Zarębska

et al. 2020

IJMS

View full text Add to dashboard Cite

Brain tumors are one of the most frightening ailments that afflict human beings worldwide. They are among the most lethal of all adult and pediatric solid tumors. The unique cell-intrinsic and microenvironmental properties of neural tissues are some of the most critical obstacles that researchers face in the diagnosis and treatment of brain tumors. Intensifying the search for potential new molecular markers in order to develop new effective treatments for patients might resolve this issue. Recently, the world of non-coding RNAs (ncRNAs) has become a field of intensive research since the discovery of their essential impact on carcinogenesis. Some of the most promising diagnostic and therapeutic regulatory RNAs are long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and small nucleolar RNAs (snoRNAs). Many recent reports indicate the important role of these molecules in brain tumor development, as well as their implications in metastasis. In the following review, we summarize the current state of knowledge about regulatory RNAs, namely lncRNA, circRNAs, and snoRNAs, and their impact on the development of brain tumors in children and adults with particular emphasis on malignant primary brain tumors—gliomas and medulloblastomas (MB). We also provide an overview of how these different ncRNAs may act as biomarkers in these tumors and we present their potential clinical implications.

show abstract

Enhancement of drug permeability across blood brain barrier using nanoparticles in meningitis

Cited by 35 publications

References 50 publications

Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications

Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications

Progress in the Application of Nanoparticles and Graphene as Drug Carriers and on the Diagnosis of Brain Infections

Non-Coding RNAs in Brain Tumors, the Contribution of lncRNAs, circRNAs, and snoRNAs to Cancer Development—Their Diagnostic and Therapeutic Potential

Contact Info

Product

Resources

About