Enhancement of electrical signaling in neural networks on graphene films

Tang, Mingliang; Qin, Song; Li, Ning; Jiang, Zaiyong; Huang, Rong; Cheng, Guosheng

doi:10.1016/j.biomaterials.2013.05.024

Cited by 207 publications

(181 citation statements)

References 36 publications

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“…Tang et al evaluated the effects of graphene on the functional formation and neural activities in the assembly of neural networks in NSCs culture. [ 100 ] Graphene was developed as an electrode to observe the cell response to the electrical stimulation. With electrical stimuli, the cells exhibited approximately 30% fl uorescence intensity increase, which clearly implied that the electrical stimulation could be transferred to the neurons by conductive graphene.…”

Section: Improving Neural Electrical Performance After Electrical Stimentioning

confidence: 99%

Graphene‐Based Materials in Regenerative Medicine

Ding

Liu

Fan

2015

Adv Healthcare Materials

147

100

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Graphene possesses many unique properties such as two-dimensional planar structure, super conductivity, chemical and mechanical stability, large surface area, and good biocompatibility. In the past few years, graphene-based materials have risen as a shining star on the path of researchers seeking new materials for future regenerative medicine. Herein, the recent research advances made in graphene-based materials mostly utilizing the mechanical and electrical properties of graphene are described. The most exciting findings addressing the impact of graphene-based materials on regenerative medicine are highlighted, with particular emphasis on their applications including nerve, bone, cartilage, skeletal muscle, cardiac, skin, adipose tissue regeneration, and their effects on the induced pluripotent stem cells. Future perspectives and emerging challenges are also addressed in this Review article.

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Section: Improving Neural Electrical Performance After Electrical Stimentioning

confidence: 99%

Graphene‐Based Materials in Regenerative Medicine

Ding

Liu

Fan

2015

Adv Healthcare Materials

147

100

View full text Add to dashboard Cite

show abstract

“…Carbon-based nanosubstrates, such as carbon nanotubes, 13,14 carbon nanohorns, 15 carbon nanofibers, 16 and graphene, 17,18 have been investigated widely for stem cell therapies and tissue engineering platforms because of their unique physical, chemical, and mechanical properties. Graphene oxide (GO) in a two-dimensional honeycomb lattice of a carbon monolayer is obtained by oxidation and exfoliation of graphite.…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide scaffold accelerates cellular proliferative response and alveolar bone healing of tooth extraction socket

Nishida¹,

Miyaji²,

Kato³

et al. 2016

IJN

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Graphene oxide (GO) consisting of a carbon monolayer has been widely investigated for tissue engineering platforms because of its unique properties. For this study, we fabricated a GO-applied scaffold and assessed the cellular and tissue behaviors in the scaffold. A preclinical test was conducted to ascertain whether the GO scaffold promoted bone induction in dog tooth extraction sockets. For this study, GO scaffolds were prepared by coating the surface of a collagen sponge scaffold with 0.1 and 1 μg/mL GO dispersion. Scaffolds were characterized using scanning electron microscopy (SEM), physical testing, cell seeding, and rat subcutaneous implant testing. Then a GO scaffold was implanted into a dog tooth extraction socket. Histological observations were made at 2 weeks postsurgery. SEM observations show that GO attached to the surface of collagen scaffold struts. The GO scaffold exhibited an interconnected structure resembling that of control subjects. GO application improved the physical strength, enzyme resistance, and adsorption of calcium and proteins. Cytocompatibility tests showed that GO application significantly increased osteoblastic MC3T3-E1 cell proliferation. In addition, an assessment of rat subcutaneous tissue response revealed that implantation of 1 μg/mL GO scaffold stimulated cellular ingrowth behavior, suggesting that the GO scaffold exhibited good biocompatibility. The tissue ingrowth area and DNA contents of 1 μg/mL GO scaffold were, respectively, approximately 2.5-fold and 1.4-fold greater than those of the control. Particularly, the infiltration of ED2-positive (M2) macrophages and blood vessels were prominent in the GO scaffold. Dog bone-formation tests showed that 1 μg/mL GO scaffold implantation enhanced bone formation. New bone formation following GO scaffold implantation was enhanced fivefold compared to that in control subjects. These results suggest that GO was biocompatible and had high bone-formation capability for the scaffold. The GO scaffold is expected to be beneficial for bone tissue engineering therapy

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“…It has been reported that graphene oxide (GO), a monolayer of carbon, is a good tissue engineering substrate due to its unique physicochemical properties, including large surface area, high dispersibility and hydrophilicity 8) . GO can promote biological interactions due to its many surface functional groups 9,10) . Several investigators have reported that GO can serve as a carrier for drugs and other biomolecules 11,12) .…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide coating facilitates the bioactivity of scaffold material for tissue engineering

Nishida

Miyaji

Takita

et al. 2014

Jpn. J. Appl. Phys.

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Carbon-based nanomaterials are being investigated for biomedical applications. Graphene oxide (GO), a monolayer of carbon, holds promise as a tissue engineering substrate due to its unique physicochemical properties. The aim of this study was to evaluate the effect of a GO coating on cell proliferation and differentiation in vitro. We also assessed the bioactivities of collagen scaffolds coated with different concentrations of GO in rats. The results showed that GO affects both cell proliferation and differentiation, and improves the properties of collagen scaffolds. Subcutaneous implant tests showed that low concentrations of GO scaffold enhances cell in-growth and is highly biodegradable, whereas high concentrations of GO coating resulted in adverse biological effects.Consequently, scaffolds modified with a suitable concentration of GO are useful as a bioactive material for tissue engineering.

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Enhancement of electrical signaling in neural networks on graphene films

Cited by 207 publications

References 36 publications

Graphene‐Based Materials in Regenerative Medicine

Graphene‐Based Materials in Regenerative Medicine

Graphene oxide scaffold accelerates cellular proliferative response and alveolar bone healing of tooth extraction socket

Graphene oxide coating facilitates the bioactivity of scaffold material for tissue engineering

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