2012
DOI: 10.1271/bbb.110468
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Enhancement of Endothelial Progenitor Cell Numbers and Migration by H1152, a Rho Kinase Specific Inhibitor

Abstract: Endothelial progenitor cells (EPCs) are applied in the treatment of ischemic diseases. In ex vivo culture of human cord-blood derived EPCs, H1152, (S)-(+)-2-methyl-1-[(4-methyl-5-iso-quinolinyl) sulfonyl]-homopiperazine, markedly increased the number of EPCs. It also induced EPC migration, stimulated the phosphorylation of AKT, and reduced the expression of p27 in the EPCs. Thus H1152 can be used effectively in ex vivo expansion of EPCs.

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Cited by 5 publications
(3 citation statements)
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“…diMF has been extensively studied as a ROCK inhibitor and characterized in pre-clinical models. It promotes generation of pancreatic beta-like cells from human pluripotent stem cells [30], augments neurite extension [31], enhances proliferation and migration of endothelial progenitor cells [32], and triggers cell-cycle arrest and cellular senescence of mouse embryo fibroblasts [33]. However, ROCKindependent activity has also been ascribed to diMF.…”
Section: Discussionmentioning
confidence: 99%
“…diMF has been extensively studied as a ROCK inhibitor and characterized in pre-clinical models. It promotes generation of pancreatic beta-like cells from human pluripotent stem cells [30], augments neurite extension [31], enhances proliferation and migration of endothelial progenitor cells [32], and triggers cell-cycle arrest and cellular senescence of mouse embryo fibroblasts [33]. However, ROCKindependent activity has also been ascribed to diMF.…”
Section: Discussionmentioning
confidence: 99%
“…diMF has been extensively studied as a ROCK inhibitor and characterized in preclinical models. It promotes generation of pancreatic beta-like cells from human pluripotent stem cells [35], augments neurite extension [36], enhances proliferation and migration of endothelial progenitor cells [37] and triggers cell-cycle arrest and cellular senescence of mouse embryo fibroblasts [38]. However, ROCK-independent activity has also been ascribed to diMF.…”
Section: Plos Onementioning
confidence: 99%
“…A derivative of fasudil, discovered in 2002, dimethylfasudil or H-1152 , is a more selective inhibitor of ROCK (Sasaki et al ., 2002 ). It has been shown to possess endothelium-modulating effects similar to those of fasudil (Breyer et al ., 2012 ; O et al ., 2012 ; Wang et al ., 2012 ) and could, therefore, potentially be further developed for use in manipulating leukocyte extravasation. It was recently also suggested as a promising agent in maintaining the integrity of the endothelial barrier upon lethal anthrax toxin challenge (Warfel and D'Agnillo, 2011 ).…”
Section: Rho and Its Kinasesmentioning
confidence: 99%