Enhancement of endothelialisation of coronary stents by laser surface engineering

Li, Lin; Mirhosseini, Nazanin; Michael, Alun; Zhu, Liu; Wang, Tao

doi:10.1002/lsm.22180

Cited by 18 publications

(19 citation statements)

References 31 publications

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“…However, previous in vitro studies suggest possible factors, which are directly related to surface chemistry and physics. First, endothelial cell adhesion was enhanced by high nitrogen concentration at the surface of stainless steel 316 L in stents for coronary artery treatment [ 27 ]. Also in the electropolished/blue oxide specimens tested in this study, nitrogen concentration formed during annealing after electropolishing was considerably higher than in native oxide.…”

Section: Discussionmentioning

confidence: 99%

In vitro investigation of chemical properties and biocompatibility of neurovascular braided implants

Cattaneo

Bräuner

Siekmeyer³

et al. 2019

J Mater Sci: Mater Med

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Braiding of Nitinol micro wires is an established technology for the manufacturing of fine-meshed neurovascular implants for tortuous vessel geometries. Electropolishing of wires before the braiding process has the potential to improve the in vitro behaviour in terms of thrombogenicity and endothelial cell proliferation. In this study, we present the first in vitro investigation of braided electropolished/blue oxide Nitinol samples in a blood flow loop, showing a significantly lower activation of the coagulation pathway (represented by the TAT III marker) and a tendency towards reduced platelet adhesion. Furthermore, we applied the same surface treatment on flat disks and measured protein adhesion as well as endothelial cell proliferation. We compared our results to non-electropolished samples with a native oxide surface. While platelet deposition was reduced on electropolished/blue oxide surface, a significant increase of endothelial cell seeding was observed. Investigation of inflammatory marker expression in endothelial cells provided divergent results depending on the marker tested, demanding closer investigation. Surface analysis using Auger electron spectroscopy revealed a thin layer mainly consisting of titanium oxynitride or titanium oxide + titanium nitride as a potential cause of the improved biological performance. Translated to the clinical field of intracranial aneurysm treatment, the improved biocompatibility has the potential to increase both safety (low thrombogenicity) and effectiveness (aneurysm neck reconstruction).

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Section: Discussionmentioning

confidence: 99%

In vitro investigation of chemical properties and biocompatibility of neurovascular braided implants

Cattaneo

Bräuner

Siekmeyer³

et al. 2019

J Mater Sci: Mater Med

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“…The surface roughness properties of this study contribute to providing data for such a standard and a methodology for making further measurements. This would enable artificially created surfaces, such as textured materials and stents, and surfaces encouraging endothelialisation coverage, 56 , 73 , 93 , 109 to be compared to healthy coronary arteries. Potentially this information could also be used to analyse disease.…”

Section: Discussionmentioning

confidence: 99%

“… 44 However, assessment of changes to the surfaces of vessels have been qualitative. 11 If stents or biomaterials are to be designed to mimic natural surfaces, for example by nano-texturing, 83 or grafts designed to encourage endothelialisation, 56 , 73 , 93 , 109 then it is necessary to quantify the properties of the surface of healthy coronary arteries. Surface roughness can be quantified using Ra (the arithmetic average of absolute values of sampling length).…”

Section: Introductionmentioning

confidence: 99%

Dynamic Viscoelasticity and Surface Properties of Porcine Left Anterior Descending Coronary Arteries

Burton

Freij

Espino

2016

Cardiovasc Eng Tech

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The aim of this study was, for the first time, to measure and compare quantitatively the viscoelastic properties and surface roughness of coronary arteries. Porcine left anterior descending coronary arteries were dissected ex vivo. Viscoelastic properties were measured longitudinally using dynamic mechanical analysis, for a range of frequencies from 0.5 to 10 Hz. Surface roughness was calculated following three-dimensional reconstructed of surface images obtained using an optical microscope. Storage modulus ranged from 14.47 to 25.82 MPa, and was found to be frequency-dependent, decreasing as the frequency increased. Storage was greater than the loss modulus, with the latter found to be frequency-independent with a mean value of 2.10 ± 0.33 MPa. The circumferential surface roughness was significantly greater (p < 0.05) than the longitudinal surface roughness, ranging from 0.73 to 2.83 and 0.35 to 0.92 µm, respectively. However, if surface roughness values were corrected for shrinkage during processing, circumferential and longitudinal surface roughness were not significantly different (1.04 ± 0.47, 0.89 ± 0.27 µm, respectively; p > 0.05). No correlation was found between the viscoelastic properties and surface roughness. It is feasible to quantitatively measure the viscoelastic properties of coronary arteries and the roughness of their endothelial surface.

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“…[9][10][11][12][13] Surface texture in micro-and nano level as well as chemistry should be controlled to tailor the biological performance of the implant. 14 Hence, laser surface texturing of implant materials has received a great deal of attention from scientific communities, mainly concentrating on permanent implant materials such as stainless steel, 15 Ti-alloys, 16 and CoCr alloys. 17 More recently, the scientific communities have focused their attention toward biodegradable metals as implant materials for temporary grafting.…”

Section: Introductionmentioning

confidence: 99%

Two-beam interference patterning of biodegradable magnesium alloy: Influence of number of passes and spots overlap

Furlan

Biondi

Demir

et al. 2017

Journal of Vacuum Science &Amp; Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phen

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Laser based texturing methods provide enhanced surface properties exploitable, especially in biomedical applications. Direct writing methods allow for processing features in tens of micrometers in size due to the use of diffraction limited beams. Feature size can be further reduced exploiting the light interference combined with the pulsed laser ablation. In this work, an industrial grade single mode nanosecond-pulsed green fiber laser was used to realize two-beam direct laser interference patterning system. The system was employed on a biodegradable Mg alloy to test the feasibility of the approach for submicrometric patterning. The combination of low melting point and high thermal conductivity of Mg alloy with the use nanosecond pulses generates difficulties in terms of the machining quality. The influence of number of pulses and number of passes was evaluated on the patterned area diameter as well as the pattern periodicity. Finally, patterned regions were overlapped on a scanned line to assess the feasibility of the process on larger areas.

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Enhancement of endothelialisation of coronary stents by laser surface engineering

Cited by 18 publications

References 31 publications

In vitro investigation of chemical properties and biocompatibility of neurovascular braided implants

In vitro investigation of chemical properties and biocompatibility of neurovascular braided implants

Dynamic Viscoelasticity and Surface Properties of Porcine Left Anterior Descending Coronary Arteries

Two-beam interference patterning of biodegradable magnesium alloy: Influence of number of passes and spots overlap

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