Enhancement of (−)-epigallocatechin-3-gallate and theaflavin-3-3′-digallate induced apoptosis by ascorbic acid in human lung adenocarcinoma SPC-A-1 cells and esophageal carcinoma Eca-109 cells via MAPK pathways

Gao, Ying; Li, Wei; Jia, Ling-Yan; Li, Bo; Chen, Yi Charlie; Tu, Youying

doi:10.1016/j.bbrc.2013.07.078

Cited by 42 publications

(33 citation statements)

References 22 publications

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“…This proposal is consistent with our results since the frequencies of apoptotic cells (particularly, late apoptotic cells) indeed increased signiicantly with the administration of vitamin C, and their administration prior to treatment of V 2 O 5 increased them even further [8]. Additionally, other studies have reported that the apoptosis-inducing activity of antioxidants might be synergistically enhanced by a combined treatment with chemopreventive [44] or genotoxic agents [40]. Therefore, it is plausible that enhanced induction of apoptosis following a combined treatment may positively contribute to the elimination of the cells with V 2 O 5 -induced DNA damage (MN-PCE).…”

Section: Protective Efects Of Vitamin C Against Genotoxic Damage Fromsupporting

confidence: 92%

The Role of Vitamin C in the Protection and Modulation of Genotoxic Damage Induced by Metals Associated with Oxidative Stress

2017

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This chapter reviews the efects of vitamin C on metal-induced genotoxicity. By focusing on cuting-edge studies, including our own results in experiments with vanadium(V) and chromium(VI), the suggestion that vitamin C can be used efectively to protect against or reduce the genotoxic efects induced by metal exposure by suppressing oxidative stress is particularly explored. After explaining the chemical mechanisms involved in oxidative stress associated with heavy metals, this chapter discusses the various proposals regarding the physiological processes of vitamin C at the molecular level, its relationship with oxidative stress, levels of 8-hydroxydeoxyguanosine 7, and apoptosis, and its role in the protection and modulation of DNA damage, as well as how they it with our own results that showed an increase in apoptosis and 8-OH-dG when vitamin C was administered in addition to the metallic compounds. The relevant gaps in our understanding of the role of vitamin C with regard to these issues are highlighted, as well as the key importance of its clinical use, and ultimately, human health.

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Section: Protective Efects Of Vitamin C Against Genotoxic Damage Fromsupporting

confidence: 92%

The Role of Vitamin C in the Protection and Modulation of Genotoxic Damage Induced by Metals Associated with Oxidative Stress

2017

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“…DOX encapsulated in 6-O-(3-hexadecyloxy-2-hydroxypropyl)-hyaluronic acid nanoparticles, 9HDHA-NPs, with EGCG significantly inhibits the growth of Ehrlich ascites tumors (Ray et al 2013). Further, EGCG in combination with vitamin A or ascorbic acid has been reported to show beneficial effects for B16 melanoma and other types of cancer prevention (Gao et al 2013;Lee et al 2010;Wel et al 2003). …”

Section: Green Tea Has Anti-inflammatory and Anticancer Propertiesmentioning

confidence: 95%

Green tea polyphenols and their potential role in health and disease

2015

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There is a growing body of evidence that plant polyphenols such as resveratrol, anthocyanins, catechins, and terpenes like taxol are effectively used in the treatment of chronic conditions including cancer, Alzheimer, Parkinsonism, diabetes, aging, etc. The link between oxidative stress and inflammation is well accepted. Thus, the mechanism of action of these natural products is partly believed to be through their significant antioxidant properties. The main constituent of green tea, with clinical significance, is epigallocatechin gallate (EGCG). It has been associated with antitumor, anti-Alzheimer, and anti-aging properties, improve redox status at the tissue level possibly preventing system level structural damage. This review focuses on EGCG and its potential therapeutic role in health and disease.

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“…A number studies have shown that vitamin C inhibits proliferation of lung cancer cells, and demonstrates synergism with tea polyphenols by modulating different signaling pathways. [32][33][34][35] Studies have also shown that combination of ascorbic acid and α-tocopherol prevented smoke-induced lung squamous metaplasia in ferrets, 36 and a combination of vitamin C and vitamin K3 inhibited tumor growth and metastasis of Lewis lung carcinoma xenograft in mice. 37 In the 1970s, Linus Pauling promoted the use of vitamin C to prevent the common cold, and later for the treatment of cancer including lung cancer.…”

Section: Vitamin Cmentioning

confidence: 94%

Cancer Preventive and Therapeutic Properties of Fruits and Vegetables Against Lung Cancer

Sakthivel¹,

Monisha²,

Kunnumakkara³

et al. 2015

Anticancer Properties of Fruits and Vegetables

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Enhancement of (−)-epigallocatechin-3-gallate and theaflavin-3-3′-digallate induced apoptosis by ascorbic acid in human lung adenocarcinoma SPC-A-1 cells and esophageal carcinoma Eca-109 cells via MAPK pathways

Cited by 42 publications

References 22 publications

The Role of Vitamin C in the Protection and Modulation of Genotoxic Damage Induced by Metals Associated with Oxidative Stress

The Role of Vitamin C in the Protection and Modulation of Genotoxic Damage Induced by Metals Associated with Oxidative Stress

Green tea polyphenols and their potential role in health and disease

Cancer Preventive and Therapeutic Properties of Fruits and Vegetables Against Lung Cancer

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