Enhancement of Healing of Long Tubular Bone Defects in Rabbits Using a Mixture of Atelocollagen Gel and Bone Marrow Aspirate Concentrate

Abstract

We evaluated the bone-forming potential of a mixture of atelocollagen and bone marrow aspirate concentrate which was transplanted into bone defects. Radial shaft defects of about 10 mm in size were created in 30 New Zealand white rabbits. Ten rabbits in the control group were not treated further, 10 rabbits in the first experimental group (E1) received an atelocollagen injection, and 10 rabbits in the second experimental group (E2) received an injection of a mixture of atelocollagen and bone marrow aspirate concentrate. The groups were compared radiologically at 8 weeks. Osteogenesis in group E2 progressed more rapidly than that in the other groups, and osteogenesis in group E1 progressed faster than that in the control group. Thus, the administration of a mixture of atelocollagen and bone marrow aspirate concentrate in bone defects was found to enhance bone defect healing.

Improved Healing of Rabbit Patellar Tendon Defects After an Atelocollagen Injection

“…In the model, the central portion of the patellar tendon was surgically excised, and the injured site underwent inflammatory and proliferative processes, matrix synthesis, and remodeling for tissue repair. 20…”

“…In the model, the central portion of the patellar tendon was surgically excised, and the injured site underwent inflammatory and proliferative processes, matrix synthesis, and remodeling for tissue repair. 20 During natural healing, the defect gap should be filled with a blood clot, releasing cytokines to attract macrophages. Macrophages play a major role in promoting proper wound healing as well as the resolution of inflammation in response to a pathogenic challenge or tissue damage.…”

Injectable Porous Bioresorbable Composite Containing Fluvastatin for Bone Augmentation

“…It is often used as a tissue engineering scaffold to culture cells. 24 Meanwhile, atelocollagen has active effect on guiding tissue regeneration, 25,26 it promotes osteoblast differentiation and type I collagen production, thus causing bone regeneration. 27 In the present study, structures and in vitro release kinetics were investigated.…”