Enhancement ofin vitroandin vivoanticancer activities of polysaccharide peptide fromGrifola frondosaby chemical modifications

Chan, Janet Yuen Yan; Chan, Enoch; Chan, Shun Wan; Sze, Shun Yin; Chan, Ming Fai; Tsui, Siu Hung; Leung, Kit Yee; Chan, Robbie; Chung, Ivan Ying Ming

doi:10.3109/13880209.2011.569557

Cited by 22 publications

(10 citation statements)

References 28 publications

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“…versicolor PSP augmented the cytotoxicity of S-phase targeted-drugs like etoposide and doxorubicin on ZR-75-30 human breast cancer cells and HL-60 human leukemia cells and decreased ratio of Bcl-xL/Bax protein expression in the tumor cells (Wan et al 2008). Acetylated, esterified, and phosphorylated Grifola frondosa polysaccharide-peptides displayed augmented adjuvant action to cyclophosphamide treatment on rats inoculated with C6 cancer cells and an enhanced growth inhibitory action on C6 cancer cells but not on normal brain cells (Chan et al 2011). Sarcoma-180-bearing mice receiving injections of three water-soluble neutral proteoglycans derived from P. ostreatus mycelia demonstrated a decline in the tumor cell number and cell cycle arrest of the tumor cells in pre-G0/G1 phase.…”

Section: Fungal Proteins and Peptides With Antitumor Activitymentioning

confidence: 97%

Fungal proteinaceous compounds with multiple biological activities

Cheung

Wong

et al. 2016

Appl Microbiol Biotechnol

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Fungi comprise organisms like molds, yeasts and mushrooms. They have been used as food or medicine for a long time. A large number of fungal proteins or peptides with diverse biological activities are considered as antibacterial, antifungal, antiviral and anticancer agents. They encompass proteases, ribosome inactivating proteins, defensins, hemolysins, lectins, laccases, ribonucleases, immunomodulatory proteins, and polysaccharopeptides. The target of the present review is to update the status of the various bioactivities of these fungal proteins and peptides and discuss their therapeutic potential.

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Section: Fungal Proteins and Peptides With Antitumor Activitymentioning

confidence: 97%

Fungal proteinaceous compounds with multiple biological activities

Cheung

Wong

et al. 2016

Appl Microbiol Biotechnol

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“…And the derivatives of maitake polysaccharide‐peptides (MPSP) showed adjuvant effect to C6 cancer cells. The rank order was phosphorylated MPSP > esterified MPSP ≥ acetylated MPSP ≥ crude MPSP (Chan et al., 2011). And Figure 4 showed the brief conclusion on the antitumor research of polysaccharides from G. frondosa .…”

Section: Polysaccharides From Mushroomsmentioning

confidence: 99%

Polysaccharides from traditional Asian food source and their antitumor activity

Yang

Chen

Sun

et al. 2021

Journal of Food Biochemistry

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Polysaccharides extracted from Asian traditional food source have been demonstrated to possess different antitumor activities mostly without side effect. In this paper, we reviewed many kinds of polysaccharides from different Asian food source and their antitumor activities. Some are common food such as different mushroom with more research. Some are special e.g., Ginseng,Salvia,Astragalus,Lycium barbarum etc. with relatively fewer research. This review mainly focused on their structure, derivatives, antitumor activities and their mechanism of action in the last decades. It aimed to bridge traditional Asian ingredients with tumor and cancer curation in order to avoid side effect of traditional treatment. Practical applications There are abundant resources of Asian food. And polysaccharides from these resources have been showed good antitumor activities and immunopotentiating activity. This review introduced the advance of the polysaccharides and their antitumor activities, which will promote the development antitumor medicine derived from Asian food source, or their applications as Adjuvant therapy of traditional chemotherapy and radiotherapy. Due to their multiple antitumor activities, enhancing immunity potential, and non‐toxic side‐effects, it might be utilized for the treatment of multiple tumors and improve the health and the life quality of patients whether as anti‐tumor drugs or as adjuvant therapy method. Furthermore, traditional Asian food source is rich. In the near future, more and more efficient polysaccharides with antitumor activities of Asian food source will be discovered. There will be broad application market for the polysaccharides.

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“…Our previous data have shown the anti-inflammatory, anti-oxidant, and hepatoprotective effects of mycelium polysaccharides from P. geesteranus [30]. Moreover, previous studies found that acetylated modification of Grifola frondosa polysaccharides could markedly enhance both adjuvant and growth inhibitory effects [31]. However, the effects of acetylated polysaccharides of P. geesteranus on ALI have not been reported.This work was designed to investigate anti-inflammatory and lung protection effects of acetylated P. geesteranus polysaccharides (AcPPS) on ALI, and explore the NF-κB signal pathway preliminarily, to identify the underlying mechanisms for the clinical application.…”

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confidence: 96%

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confidence: 96%

Acetylated Polysaccharides From Pleurotus geesteranus Alleviate Lung Injury Via Regulating NF-κB Signal Pathway

Song

Zhang

2020

IJMS

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The present work investigated the anti-inflammatory, antioxidant, and lung protection effects of acetylated Pleurotus geesteranus polysaccharides (AcPPS) on acute lung injury (ALI) mice. The acetylation of AcPPS was successfully shown by the peaks of 1737 cm−1 and 1249 cm−1 by FTIR. The animal experiments demonstrated that lung damage can be induced by zymosan. However, the supplementation of AcPPS had potential effects on reducing lung index, remitting inflammatory symptoms (TNF-α, IL-1β, and IL-6), inhibiting NF-κB signal pathway based on up-regulating the level of IκBα and down-regulating p-IκBα level by Western blotting and immunofluorescence assay, preventing oxidative stress (ROS, SOD, GSH-Px, CAT, T-AOC, and MDA), reducing lipid accumulation (TC, TG, LDL-C, HDL-C, and VLDL-C), and alleviating lung functions by histopathologic observation. These results demonstrated that AcPPS might be suitable for natural food for prevention or remission in ALI.

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Enhancement ofin vitroandin vivoanticancer activities of polysaccharide peptide fromGrifola frondosaby chemical modifications

Cited by 22 publications

References 28 publications

Fungal proteinaceous compounds with multiple biological activities

Fungal proteinaceous compounds with multiple biological activities

Polysaccharides from traditional Asian food source and their antitumor activity

Acetylated Polysaccharides From Pleurotus geesteranus Alleviate Lung Injury Via Regulating NF-κB Signal Pathway

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