2022
DOI: 10.1002/jsfa.12043
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Enhancement of immune responses using ovalbumin‐conjugatedEucommia ulmoides leaf polysaccharides encapsulated in a cubic liquid‐crystalline phase delivery system

Abstract: BACKGROUND: To improve the adjuvant activity of polysaccharides from Eucommia ulmoides leaves (PsEUL) in inducing an effective immune response against ovalbumin (OVA), PsEUL were conjugated to OVA using the N-(3-dimethylaminopropyl)-N 0 -ethylcarbodiimide hydrochloride (EDC) method. The synthesized PsEUL-OVA was encapsulated using phytantriol and F127 to produce PsEUL-OVA cubosomes (Cubs), a novel delivery system. The physicochemical properties and immune modulation effects of this novel delivery system were e… Show more

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Cited by 7 publications
(1 citation statement)
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“…Moreover, there are studies that show that an imbalance in intestinal flora is a pivotal factor in the initiation and progression of alcoholic liver injury [6,7]. Recently, polysaccharides have garnered a lot of attention in alcohol liver injury due to their varied actions, such as anti-inflammation, antioxidant, anti-tumor, and enhancement of immune activity [8][9][10][11][12][13][14][15], as well as the ability to regulate the gut microbiota, thereby exerting positive efforts on host health [16,17].…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, there are studies that show that an imbalance in intestinal flora is a pivotal factor in the initiation and progression of alcoholic liver injury [6,7]. Recently, polysaccharides have garnered a lot of attention in alcohol liver injury due to their varied actions, such as anti-inflammation, antioxidant, anti-tumor, and enhancement of immune activity [8][9][10][11][12][13][14][15], as well as the ability to regulate the gut microbiota, thereby exerting positive efforts on host health [16,17].…”
Section: Introductionmentioning
confidence: 99%