Enhancement of indocyanine green stability and cellular uptake by incorporating cationic lipid into indocyanine green-loaded nanoemulsions

Lee, Eun‐Hye; Kim, Jin‐Ki; Lim, Joon-Seok; Lim, Soo-Jeong

doi:10.1016/j.colsurfb.2015.09.025

Cited by 38 publications

(19 citation statements)

References 28 publications

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“…As a result, compared to SA-free nanoemulsions encapsulating ICG, SA-incorporated nanoemulsions encapsulating ICG exhibited higher phototoxicity upon NIR light irradiation. After subcutaneous injection into the footpad of mice, SA-incorporated nanoemulsions exhibited higher concentrations of ICG in popliteal lymph nodes compared to SA-free nanoemulsions [148].…”

Section: Anticancer Therapy Using Ps-based Formulationsmentioning

confidence: 93%

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Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

et al. 2021

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Polysorbates (PSs) are synthetic nonionic surfactants consisting of polyethoxy sorbitan fatty acid esters. PSs have been widely employed as emulsifiers and stabilizers in various drug formulations and food additives. Recently, various PS-based formulations have been developed for safe and efficient drug delivery. This review introduces the general features of PSs and PS-based drug carriers, summarizes recent progress in the development of PS-based drug formulations, and discusses the physicochemical properties, biological safety, P-glycoprotein inhibitory properties, and therapeutic applications of PS-based drug formulations. Additionally, recent advances in brain-targeted drug delivery using PS-based drug formulations have been highlighted. This review will help researchers understand the potential of PSs as effective drug formulation agents.

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Section: Anticancer Therapy Using Ps-based Formulationsmentioning

confidence: 93%

“…PS-based nanoemulsions were developed for efficient intracellular delivery of photosensitizers [148]. Indocyanine green (ICG) is a near-infrared light-absorbing dye approved by the FDA [149].…”

Section: Anticancer Therapy Using Ps-based Formulationsmentioning

confidence: 99%

Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

et al. 2021

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“…The carbon chains in the NPs bilayer could improve the stability and prevent photobleaching of photothermal materials. 49,50 As Figure 3A shown, the temperature increased with the increase of nanoparticle concentration, when the ICD-Gd concentration reached 2 mg/mL, the temperature increased by ∼27 °C in 10 min, high enough to meet the requirement of photothermal therapy. As shown in Figure 3B, the ICD nanoparticle, which was not assembled with long carbon chain from DPC, could not rise to the first peak temperature when the second round of NIR irradiation was applied.…”

Section: Resultsmentioning

confidence: 97%

“…Although IR780 changed its maximum absorbance after connecting with DOTA-Gd via cystamine, the resulting DPC@ICD-Gd still showed broad absorption in the range of 700–850 nm (Figure C, D), which made it exhibit excellent and stable photothermal properties under NIR laser irradiation (808 nm). The carbon chains in the NPs bilayer could improve the stability and prevent photobleaching of photothermal materials. , As Figure A shown, the temperature increased with the increase of nanoparticle concentration, when the ICD-Gd concentration reached 2 mg/mL, the temperature increased by ∼27 °C in 10 min, high enough to meet the requirement of photothermal therapy. As shown in Figure B, the ICD nanoparticle, which was not assembled with long carbon chain from DPC, could not rise to the first peak temperature when the second round of NIR irradiation was applied.…”

Section: Resultsmentioning

confidence: 99%

Anti-Tumor Metastasis via Platelet Inhibitor Combined with Photothermal Therapy under Activatable Fluorescence/Magnetic Resonance Bimodal Imaging Guidance

Zhang

Sun

et al. 2021

ACS Appl. Mater. Interfaces

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Photothermal therapy (PTT) is a promising tumor therapy strategy; however, heterogeneous heat distribution over the tumor often exists, resulting in insufficient photothermal ablation and potential risk of cancer metastasis, which has been demonstrated to be associate with platelets. Herein, a near-infrared (NIR) photothermal agent of IR780 was conjugated with MRI agent of Gd-DOTA via a disulfide linkage (ICD-Gd), which was coassembly with lipid connecting tumor-homing pentapeptide CREKA (Cys-Arg-Glu-Lys-Ala) (DSPE-PEG-CREKA) to encapsulate a platelet inhibitor of ticagrelor (Tic), affording a multistimuli-responsive nanosystem (DPC@ICD-Gd-Tic). The nanosystem with completely quenching fluorescence could specifically target the tumor-associated platelets and showed pH/reduction/NIR light-responsive drug release, which simultaneously resulting in dis-assembly of nanoparticle and fluorescence recovery, enabling the drug delivery visualization in tumor in situ via activatable NIR fluorescence/MR bimodal imaging. Finally, DPC@ICD-Gd-Tic further integrated the photoinduced hyperthermia and platelet function inhibitor to achieve synergistic anticancer therapy, leading to ablation of primary tumor cells and effectively suppressed their distant metastasis. The number of lung metastases in 4T1 tumor bearing mice was reduced by about 90%, and the size of tumor was reduced by about 70%, while half of the mouse was completely cured by this smart nanosystem.

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“…High surface area can increase the absorption rate and reduce the absorption variability, thus enhancing the bioavailability of the drug. Furthermore, they can protect the payload from degradation and metabolism due to encapsulation in the inner oil phase, 21 which is similar to the micellar system. 22 In stabilizing the labile drug, NEs have advantages over solid dispersions and cyclodextrin inclusion complexes.…”

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confidence: 99%

Biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability

Yin¹,

Xiang²,

Wang³

et al. 2017

IJN

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Baicalein (BCL) possesses high pharmacological activities but low solubility and stability in the intestinal tract. This study aimed to probe the potential of nanoemulsions (NEs) consisting of hemp oil and less surfactants in ameliorating the oral bioavailability of BCL. BCL-loaded NEs (BCL-NEs) were prepared by high-pressure homogenization technique to reduce the amount of surfactants. BCL-NEs were characterized by particle size, entrapment efficiency (EE), in vitro drug release, and morphology. Bioavailability was studied in Sprague-Dawley rats following oral administration of BCL suspensions, BCL conventional emulsions, and BCL-NEs. The obtained NEs were ~90 nm in particle size with an EE of 99.31%. BCL-NEs significantly enhanced the oral bioavailability of BCL, up to 524.7% and 242.1% relative to the suspensions and conventional emulsions, respectively. BCL-NEs exhibited excellent intestinal permeability and transcellular transport ability. The cytotoxicity of BCL-NEs was documented to be low and acceptable for oral purpose. Our findings suggest that such novel NEs and preparative process provide a promising alternative to current formulation technologies and suitable for oral delivery of drugs with bioavailability issues.

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Enhancement of indocyanine green stability and cellular uptake by incorporating cationic lipid into indocyanine green-loaded nanoemulsions

Cited by 38 publications

References 28 publications

Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

Anti-Tumor Metastasis via Platelet Inhibitor Combined with Photothermal Therapy under Activatable Fluorescence/Magnetic Resonance Bimodal Imaging Guidance

Biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability

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