1998
DOI: 10.1177/026988119801200213
|View full text |Cite
|
Sign up to set email alerts
|

Enhancement of latent inhibition in the rat at a high dose of clozapine

Abstract: The present experiments investigated clozapine (2.5, 5 and 10 mg/kg) and haloperidol (0.1 mg/kg) administration on latent inhibition (LI) in rats. Clozapine's ability to antagonize amphetamine-induced disruption of LI was also assessed. A conditioned emotional response procedure was employed. In the pre-exposure stage, 'pre-exposed' rats received 10 (Experiment 1) or 40 (Experiment 2) presentations of a flashing light stimulus without reinforcement. During the conditioning phase, the light stimulus was paired … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

1
14
0

Year Published

2000
2000
2009
2009

Publication Types

Select...
4
1
1

Relationship

0
6

Authors

Journals

citations
Cited by 20 publications
(15 citation statements)
references
References 27 publications
1
14
0
Order By: Relevance
“…Assuming that the effects of clozapine in preexposure are 5HT-mediated, this implies that 5HT2 and DA2 antagonistic actions of clozapine compete in LI. As noted in the Introduction, the possibility of such a competition has been raised previously by Dunn et al (1993) and Trimble et al (1998).…”
Section: Discussionmentioning
confidence: 91%
See 4 more Smart Citations
“…Assuming that the effects of clozapine in preexposure are 5HT-mediated, this implies that 5HT2 and DA2 antagonistic actions of clozapine compete in LI. As noted in the Introduction, the possibility of such a competition has been raised previously by Dunn et al (1993) and Trimble et al (1998).…”
Section: Discussionmentioning
confidence: 91%
“…In addition, since the relative potency of the two actions are dose-dependent, with 5HT2 receptor occupancy predominating at lower doses and DA2 receptor occupancy occurring at higher doses (Schotte et al 1996), the effects of clozapine on LI should be dosedependent (Trimble et al 1998). Given the above, depending on the parametric conditions and doses of clozapine, the serotonergic component should be able to override the dopaminergic component, or vice versa, leading to either potentiated LI, intact LI, or disrupted LI.…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations